Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 25 for “"cotinine"”.
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Evaluation and Clinical Implications of Biomarkers of Electronic Cigarette Use
… have gained a considerable popularity in the US. Cotinine is a nicotine metabolite excreted with urine and it is a common biomarker used to verify patient’s smoking status in clinical settings. However, cotinine is a biomarker that is selective for all nicotine-containing products and does not …
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RILIEVO DI FATTORI XENOBIOTICI, CON PARTICOLARE RIFERIMENTO A NICOTINA E COTININA, IN CAMPIONI ISTOLOGICI APPARTENENTI A FETI E NEONATI DECEDUTI PER CAUSE NATURALI.
… OF XENOBIOTIC FACTORS, ESPECIALLY OF NICOTINE E COTININE, ON HISTOLOGICAL SAMPLES COLLECTED FROM FETUSES AND NEWBORNS DEAD FOR NATURAL CAUSES. As Sudden Infant Death Syndrome still holds many unknown etiopathogenetic aspects and as analytic chemical instruments and methods have appreciably …
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E-Cigarettes: Biomarkers of Exposure and the Development and Validation of a Research Toolkit
… thesis therefore directly compared the urinary cotinine levels, a biomarker of nicotine exposure, in individuals who use ENDS exclusively, use ENDS in conjunction with smoking tobacco cigarettes (dual users), and smoke cigarettes exclusively. We found no significant differences in cotinine …
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Identification of Tobacco-Related Compounds in Tobacco Products and Human Hair
… determination of nicotine and its metabolite, cotinine. The theory of TV-SPME is to completely vaporize an organic extract which will eliminate the partitioning between the sample and the headspace, thereby simplifying the thermodynamic equilibrium. Parameters such as sample volume, incubation …
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Determination of nicotine and its metabolites by capillary electrophoresis and mass spectrometry.
… lower detection limits (LODs of nicotine and cotinine, by CE-sample stacking/ MS (via HE injection), were found to be 0.11 and 2.25 mug/ mL, respectively) when compared to sample stacking/MS via hydrodynamic or electrokinetic injection alone. The added selectivity that the selected ion …
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Novel analytical methods for the investigation of nicotine metabolism.
… chromatography (HPLC) may also be compromised if cotinine alone is used for standardisation purposes.The use of these novel derivatives was investigated in relation to their correlation with a specific radioimmunoassay (RIA) for cotinine and the ability of the test to discriminate between smokers …
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Indoor air pollution and environmental tobacco smoke exposure in a South African birth cohort study
… compounds (VOC). Maternal and infant urine cotinine measures were used to validate self-reported tobacco smoking and exposure. Study staff trained in recognition of LRTI or wheeze documented all episodes, which were categorised according to WHO case definition criteria. Exposure to IAP was …
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Improving smoking cessation for vulnerable populations in low-resourced settings
… collected at baseline were used to determine cotinine (COT) and 3-hydroxycotinine (3HC) levels; we then calculated the NMR as a ratio of 3HC to COT. We evaluated NMR as a categorical variable (high versus normal metabolizers), using a cut-off of the fourth quartile (≥0.3174 ng/mL). …
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LC-MS/MS determination of various drugs of abuse and metabolites in municipal wastewater effluent samples
… and their various metabolites (acetylmorphine, cotinine, EDDP, amphetamine and benzoylecgonine) in municipal wastewater effluent samples. Samples were collected once daily and drugs were extracted from the wastewater with solid phase extraction using Waters Oasis MCX cartridges. …
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Interleukin-6 Levels in Generalized and Localized Aggressive Periodontitis Patients
… bleeding index, plaque index, gingival index, cotinine levels, smoking status, and CRP levels. Using multiple regression analysis, smoking status (p=0.0015) was the only variable found to have a significant relationship with IL-6 levels for all three groups.
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Tobacco Smoke Exposure and Pediatric Multiple Sclerosis
… home, as well as biomarker verification by serum cotinine, classified a child as exposed or not exposed. Logistic regression models were created to determine the association between TSE and the odds of MS compared to healthy controls, the odds of ADS compared to healthy controls, and the odds of …
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Does smoking impact on the association between oxidative stress and vascular function in young normotensives? the African-Predict study
… H4 hybrid microplate reader was used. Serum cotinine levels were determined to differentiate smokers from non-smokers. Cotinine was analyzed using Chemiluminescence method of the Immulite. Two-way ANOVA and Chi-square tests were performed to compare means and proportions between groups. …
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Behavioral Intervention for Smoking Cessation in Adolescents and Young Adults
… carbon monoxide (CO) levels but did reduce urine cotinine. Depression history and baseline level of depressive symptoms had no effect on change in smoking during treatment, but this may have been due to low power to detect differences. Exploratory analyses demonstrated that treatment was …
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EVALUATION OF ENVIRONMENTAL FACTORS ON CANINE REPRODUCTION AND FERTILITY: INNOVATIVE STRATEGIES
… exposure of breeding dogs to cigarette smoke. Cotinine was applied as marker of nicotine intake in male dogs and pregnant bitches belonging to smoking and non-smoking owners. Significant differences were highlighted between exposed and non-exposed dogs, however measurable levels of this …
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Computational Evaluation and Structure-based Design for Potentiation of Nicotine Vaccines
… compartmentalized models for nicotine and cotinine distribution. These models were then calibrated and validated using data obtained from literature. The final models verified the therapeutic potential of the NV concept, identified four key parameters associated with vaccine success, and …
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Comparing glutathione peroxidase and glutathione reductase activity and their associations with cardiovascular measures in Africans and Caucasians : the SABPA study
… serum: high sensitivity C-reactive protein (CRP) cotinine (metabolite of nicotine) and gamma glutamyl transferase (GGT). Additionally, albumin and creatinine were measured from urine samples and estimated creatinine clearance (eCrCl) was calculated. Serum peroxides (ROS) and total glutathione …
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Reversed-Phase Liquid Chromatography Tandem Mass Spectrometry And Elisa Determination Of Caffeine As A Marker For Sewage Contamination Of Wilgreen Lake
… (carbamazepine, sulfamethoxazole, trimethoprim, cotinine, paraxanthine, acetaminophen and fluoxetine) belonging to various therapeutic categories in the lake was also investigated using the LC-MS/MS method of analysis. </p> <p>Since caffeine exists in surface waters at low concentrations, solid …
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Measurement and Analysis of Cigarette Smoke Exposure and Smoking Behavior Using Wearable Sensors
… the biomarkers of smoke exposure expire CO and Cotinine level; (d) development of DeepPuff algorithm for automatic identification of smoking inhalation in the free-living environment; (e) analysis of cigarette smoking in the free-living environment and the effects of using puff topography …
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In vitro and in vivo studies on the biotransformation of β-nicotyrine, a minor tobacco alkaloid
… and hydrolysis to form 5'-hydroxycotinine. The autoxidation is likely to involve a free radical process. Evidence to support this proposal has been obtained by studies on 2-acetoxy-1-methyl-5-(3-pyridyl)pyrrole, a latent form of the pyrrolinones. Free radicals generated following …
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Forecasting the Transport and Fate of Pharmaceuticals in Coarse Grained Aquifers
… compounds were added to the analyses: nicotine, cotinine, ecstasy, methylated ecstasy, and cocaine. Batch sorption experiments and column tests were used to compute aquifer material attenuation properties. River and groundwater samples were geochemically characterized using approaches developed …
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