Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 14 of 14 for “"costimulatory molecule"”.
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GLP1R IS A T CELL NEGATIVE COSTIMULATORY MOLECULE
… conclusion, GLP1R appeared to act as a negative costimulatory molecule and the GLP1R agonist Exenatide prolongs allograft survival, mitigates alloimmunity during alloimmune response, reduces T lymphocytes graft infiltration and skews the effector/regulatory T cell balance.
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Prolonged T – DC macro-clustering within lymph node microenvironments initiates Th2 differentiation in a site-specific manner
… cDC2 across dermal tissues, with enhanced costimulatory molecule expression by cDC2 in Th2-generating LNs promoting prolonged T cell activation, macro-clustering, and cytokine sensing. Thus, generation of dedicated Th2 priming micro-environments through enhanced costimulatory molecule …
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The Function of PTPN22 and the Autoimmune Risk Variant LypW in Immune Responses to Vaccination
… transcriptional responses, or myeloid APC costimulatory molecule upregulation. LypW association with defects in TIV-induced CD4 T cell expansion and antibody affinity maturation suggests that LypW may predispose to diminished capacity to generate protective immunity against influenza.
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Understanding the function of ICOS/ICOSL costimulation in experimental autoimmune myasthenia gravis
The inducible costimulatory molecule (ICOS) is a relatively new member of the CD28 family of costimulatory molecules. For the first time, we have characterized the role of ICOS/ICOSL costimulation in experimental autoimmune myasthenia gravis (EAMG), a model of human MG. Following acetylcholine …
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TL1A Priming Induces a Multi-Cytokine Th9 Cell Phenotype That Promotes Robust Allergic Inflammation in Murine Models of Asthma
The TNF superfamily member TL1A is a costimulatory molecule that signals through its receptor DR3 on T lymphocytes. The Th9 subset of T lymphocytes secretes the pleiotropic cytokine IL-9 which has functions in allergic airway disease, helminth infections, and tumor immunity. TL1A increases IL-9 …
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Dendritic cell regulation of immunity to Leishmania donovani
… spleen. cDCs displayed a limited capacity for costimulatory molecule expression and pro-inflammatory cytokine production ex vivo. Instead, the preferential production of the immunoregulatory cytokines IL-10 and IL-27 led to the establishment of an auto- regulatory cytokine cascade, modulating …
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THE ABSENCE OF C3AR AND C5AR SIGNAL TRANSDUCTION PROMOTES T REGULATORY CELL DIFFERENTIATION AND REGULATES IMMUNOLOGIC TOLERANCE
… Absent C3aR and C5aR signaling decreases costimulatory molecule and IL-6 production and augments IL-10 production. The resulting iTregs exert robust suppression, possess enhanced stability, and suppress ongoing autoimmune disease. It has been difficult to generate stable human Tregs with …
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DISSECTING THE ROLES OF DISTINCT DENDRITIC CELL SUBSETS IN THE IMMUNE RESPONSE TO THE INTRACELLULAR BACTERIAL PATHOGEN, LISTERIA MONOCYTOGENES
… have distinct repertoires of pathogen sensing molecules and functions. Four subsets of DC have been identified in the spleen and at least two DC subsets can also be generated in vitro from mouse bone marrow using the cytokine, Fms-like tyrosine kinase 3-ligand (Flt3L). We therefore set out to …
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Combination of STING and TLR 7/8 agonists as vaccine adjuvants for cancer immunotherapy
… flow cytometry and ELISA, we investigated the costimulatory molecule expression and cytokine secretion in dendritic cells, and M2 to M1 polarization after treatment with the agonists, individually or in combination. Also, PLGA nanoparticles were formulated and characterized in vitro. We …
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Costimulatory function of CD44
… two signals via engagement of the TCR and a costimulatory molecule. However, the signaling cascade of costimulatory molecules has remained elusive. Here, I provide evidence that CD44 supports proliferation as well as apoptosis mainly, if not exclusively, by enhancing signal transduction via …
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Toll-like Receptors 2 and 9 Are Important for Innate Immune Cell Activation and Recruitment in Hypersensitivity Pneumonitis
… in bacteria, and signal through the adaptor molecule MyD88. The goal of my project is to investigate the role of TLRs 2 and 9 in the pathogenesis of HP during the acute phase, granulomatous phase, and chronic phase of the disease. Using the S. rectivirgula (SR) animal model of HP, our studies …
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A microfluidic approach for the initiation and investigation of surface-mediated signal transduction processes on a single-cell level
… T cell receptor-associated kinase CD3 and the costimulatory molecule CD28 (CD; cluster of differentiation). The stimulation of the cells with the functionalized beads led to a rapid rise of their cytosolic Ca2+ concentration which was analyzed by a dual-wavelength ratiometric fluorescence …
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TREM-2 and Dendritic Cells in the Pathogenesis of Allergic Airway Inflammation
… IRF-8 and BATF-3) as well as high expression of costimulatory molecule CD86 and chemokine receptor CCR-7.|Whole lungs from OVA-sensitized and challenged mice were then examined for TREM-2 expression. As seen with other inflammatory conditions, TREM-2 was found to be upregulated in the airways of …