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Showing 1 to 2 of 2 for “"cosmc"”.
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Untersuchung von cosmc-Mutationen bei Patienten mit IgA-Nephropathie
… (C1GALT1) and its chaperone cosmc are specifically required for O-galactosylation of the IgA1 hinge region. Mutations in the cosmc gene result in a secondary loss of function of C1GALT1 with subsequent undergalactosylation of glycoproteins. Mosaicmutations of cosmc have been …
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Investigations into altered cellular glycosylation associated with metastatic competence in breast cancer cell lines
… as well as C1GalT and its molecular chaperone COSMC. This analysis revealed that there is no clear association between aberrant glycosylation recognised by HPA-binding, although down-regulation of C1GalT and COSMC may result in failed normal chain extension. A method of isolating cells based on …