Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 15 of 15 for “"corticothalamic"”.
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Targeting NMDA Receptors to Tune Corticothalamic Circuit Function
The somatosensory corticothalamic (CT) circuit processes ascending sensory signals, and disruption to the balance of excitation and inhibition (E/I) within CT circuitry leads to absence seizures, sleep disorders, and attention deficits. E/I balance may be restored by independently modulating …
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Role of GluN2C-containing NMDA Receptors in Cellular and Behavioral Deficits Associated with Corticothalamic Circuit Dysfunction in Schizophrenia
The NMDA receptor (NMDAR) hypofunction hypothesis in schizophrenia posits that reduced NMDAR function leads to behavioral abnormalities observed in schizophrenia. Lower expression of GluN2C subunit of NMDAR has been reported in the cortex and thalamus in postmortem brains from schizophrenic …
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Modelling resting-state neural oscillations to uncover circuit mechanisms of aging and rTMS response in late-life depression
… the alpha rhythm within cortical and corticothalamic circuits, evaluating their strengths, limitations, and key parameter effects. This provided a deeper understanding of the modelled mechanistic circuits of alpha generation. In the second study, we fitted the previously explored …
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Regulation of Neuronal Excitability by Glutamate and Cholecystokinin Rodent Neocortex
… Layer VI neocortical neurons provide important corticothalamic innervation that can modulate information processing within various thalamic nuclei. Due to the presence of CCK and its receptors in deep layer neocortex, I have examined the actions of CCK on the excitability of deep layer …
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Neuronal Nicotinic Receptor Dynamics in Medial Geniculate Body Neurons of Young and Aged Fischer Brown Norway Rats
… responses evoked by stimulation of excitatory corticothalamic terminals and inhibitory tectothalamic terminals. Conversely, application of ACh appeared to have no consistent effects on paired-pulse responses evoked from stimulation of excitatory tectothalamic terminals and inhibitory …
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Novel EphB Receptor Forward Signaling Pathways in the Development of Major White Matter Tracts of the Mammalian Brain
… the corpus callosum, and the reciprocal corticothalamic and thalamocortical axon pathways. I specifically present data in which I demonstrate that Vav2 and Vav3 GEF (guanine nucleotide exchange factor) molecules form a specific forward signaling interaction with the EphB1 receptor that is …
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Biophysical model of core & matrix thalamocortical circuitry in rodents & primates
… rodents and primates. While the role of the corticothalamic system in sleep spindle generation is well established, the individual role of the core and matrix is not well understood in rodents and primates. Therefore, we created both a rodent and primate biophysical neural model of the core …
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Diverse Mechanisms Impair Thalamic Circuit Function in a Dravet Syndrome Mouse Model
… disruption. Dysfunction in the somatosensory corticothalamic (CT) circuit underlies several DS phenotypes including absence seizures and sleep disturbances. Yet, the precise mechanisms underlying somatosensory CT circuit dysfunction in DS remain unclear. Here, we sought to identify the …
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The role of cortical layer six in the perception and laminar representation of sensory change
… signals with heterogeneous receptive fields. Corticothalamic (CT) cells in Layer 6 respond sparsely, but faithfully encode stimulus identity. Weak optogenetic drive of L6 CT cells disrupted this encoding in layer 6 without affecting overall firing rates. This manipulation also caused layer 2/3 …
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Auditory Processing Deficits in MSH2-KO mice are linked to Aberrant Inhibitory Neuron Function in the Thalamic Reticular Nucleus
… reticular nucleus (TRN): a critical regulator of corticothalamic and thalamocortical activity. We observed an increase in parvalbumin (PV<sup>+</sup>) expression, density, and cell area in the TRN, as well as high aggregation of the gap junction protein connexin-36 (Cx36). Cx36 is required for …
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Dissecting the Physiological Roles of ULK1/2 in the Mouse Brain
… corpus callosum (CC), anterior commissure (AC), corticothalamic axons (CTAs) and thalamocortical axons (TCAs) and mossy fibers. These defects led to impaired midline crossing of callosal axons, anterior commissure hypoplasia and disorganization of the somatosensory cortex. The axon guidance …
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Serum Response Factor Regulates Multiple Aspects of Central Nervous System Development
… including corticostriatal, corticospinal, and corticothalamic tracts, and they show a variable loss of the corpus callosum. Neurogenesis and interneuron specification occur normally in the absence of SRF and the deficits in axonal projections were not due to a decrease or loss in cell numbers. …
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Molecular and Functional Characterization of Pyramidal Cell Types in the Frontal Cortex of Mouse Brain
… layer 5a of lateral cortex expressing Etv1 and corticothalamic neurons in layer 6 of neocortex defined by Ntsr1 and Syt6. We generated translation profiles of actively translated mRNAs in the targeted cell types with affinity purification of tagged polysomes and carried out quantitative …
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Causal control of the thalamic reticular nucleus using optogenetic and novel chemogenetic approaches
… TRN are prominent in disease Thalamocortical and corticothalamic projections synapse within this nucleus, and it is subject to a variety of neuromodulatory influences. Depolarization of TRN neurons, and their subsequent firing, is driven by a variety of sources on a range of time scales. The TRN …
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Neuronal Correlates of Reward Contingency in the Rat Thalamocortical System
<p>Perception arises from sensory inputs detected by peripheral organs and processed in the brain by complex neuronal circuits required for the integration of external information with internal states such as expectation and attention. Stimulus discrimination requires activation of primary sensory …