Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 111 for “"corticosteroids"”.
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Efficacy of oral corticosteroids for preschool wheeze
… and creates economic burdens. Although oral corticosteroids (OCS) have been widely used to treat acute wheezing episodes in clinical practice, evidence has been contentious regarding the efficacy of OCS for preschool wheeze. This thesis aims to assess the OCS treatment in treating acute …
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The targeting of corticosteroids to inflamed tissues
… of the Joints and long term patient disability, Corticosteroids have been shown to retard the progression of Joint destruction but are limited in their use due to adverse side effects,This project, following the line of investigation started by other workers, was designed to study the use of …
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Studies on the Formulation of Topical Corticosteroids
… systems were developed for assaying these two corticosteroids in the presence of their major decomposition products. The development and applications of these systems were discussed. The kinetics of decomposition were subjected to non-linear regression analysis. The rate constants for the …
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The plasma corticosteroids: their determination and normal variations
The current interest in the secretions of the adrenal cortex is shared by physiologist, physician and pharmacologists alike. such attention is not surprising in the case of a gland which is immediately essential to life, which can produce syndromes as varied as precocious puberty, virilisation; …
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Effects of Three Corticosteroids on Equine Articular Cocultures In Vitro
The objective was to compare the effects of three corticosteroids at various equimolar concentrations on equine articular explant co-cultures in an inflammatory environment. Synovial and osteochondral explant co-cultures from 6 equine cadavers were exposed to IL-1β (10 ng/mL) and various …
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Differential spectrophotometric analysis of intravenous admixtures containing metaraminol with selected corticosteroids
<p>Intravenous admixtures consisting of one or more drug formulations, diluted in a large volume of intravenous solution, are used extensively in current medical practice. Development of reliable methods to predict the compatibility of the admixture components is essential as a guide for their …
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Glioma: A Tale of Corticosteroids, Thiopurines and Proposed Novel AntiGlioma Small Molecules
… tumor resistance to chemo- and radiotherapy. Corticosteroids are mainstay drugs for managing peritumoral edema. Therefore, we investigated the effect of corticosteroids in a PDGF driven glioma mouse model. We found that corticosteroid treatment decreases tumor cell proliferation without …
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Evaluation of the Role of Adjunctive Corticosteroids in the Management of Children Hospitalized with Orbital Cellulitis
… Previous studies have suggested that corticosteroids may improve recovery in patients with orbital cellulitis. However, no large, multicenter studies have examined the use of systemic corticosteroids in children with orbital cellulitis. The objectives of this current study are to …
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Epileptic Spasms: Evidence for oral corticosteroids and implications for low and middle income countries (Systematic Review)
… in Low and Middle Income Countries (LMIC). Oral corticosteroids are alternative interventions but evidence for the optimal agent, dose, duration, efficacy and long-term effects are lacking. A systematic review of the literature was performed to assess the quality of evidence of prednisone and …
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The Effect of initiating corticosteroids on lung function and symptoms in patients with active pulmonary sarcoidosis
… morbidity and mortality, and the use of corticosteroids is a common treatment strategy1,2. The expected response to corticosteroids with respect to lung function is highly variable and not studied in an African cohort. The primary objective of our study was to investigate the impact of …
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Drug nanosizing using microfluidic reactors. Development, characterisation and evaluation of corticosteroids nano-sized particles for optimised drug delivery.
Over recent years the delivery of nanosized drug particles has shown potential in improving bioavailability. Drug nanosizing is achieved by ¿top-down¿ and by ¿bottom-up¿ approaches. Owing to limitations associated with the top-down techniques, such as high energy input, electrostatic effects, broad …
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Fluorine-18-labeled estrogens, progestins and corticosteroids for receptor-based imaging of breast tumors and target areas of the brain
Estrogens can be labeled with the positron-emitting radionuclide fluorine-18 (t$\sb{1/2}$ = 110 min) by fluoride ion (n-Bu$\sb4$N$\sp{18}$F) displacement of a 16$\beta$-trifluoromethanesulfonate (triflate) derivative of the corresponding estrone 3-triflate, and purification by HPLC. That sequence …
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Effectiveness of inhaled corticosteroids in preventing morbidity and mortality in individuals with chronic obstructive pulmonary disease and the impact of coexisting asthma
… burden of illness posed by COPD alone. Inhaled corticosteroids (ICS) are currently recommended for the management of COPD among individuals with frequent exacerbations; however, the ability of inhaled corticosteroids to reduce death and hospitalizations among individuals with COPD is …
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Long-term impacts of antenatal corticosteroid exposure and preterm birth
Antenatal corticosteroids are recommended for women at risk of preterm birth before 35 weeks’ gestation for reducing the significant neonatal morbidity and mortality caused by preterm birth. The long-term impacts of both preterm birth and antenatal corticosteroids are incompletely understood. The …
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The 21-dehydroxylation of corticosteroids: evidence for an enol intermediate and the hydroxylation of steroids by fungal cyto-chrome P450: evidence for a stepwise mechanism
… were examined: the 21-dehydroxylation of corticosteroids by the anaerobe Eubacterium l en tum, and the hydroxylation of steroids by fungal cytochrome P450. Deuterium labelling techniques were used to study the enzymic dehydroxylation. Corticosteroids doubly labelled (2H) at the C-21 …
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I.~fluorine-18 Labeled Corticosteroids and Progestins for Receptor-Based Imaging of the Brain and of Breast Tumors. II.~Synthesis and NMR Spectrum of (carbon-13(18))-Meso-Hexestrol
… fluorinated analogs of six natural and synthetic corticosteroids as potential diagnostic imaging agents for Alzheimer's dementia. Four of these ligands have been prepared in fluorine-18 labeled form (three in high specific activity, 369-1618 Ci/mmol), by fluoride ion (n-Bu$\sb4$N$\sp $F) …
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Investigation of novel topical therapeutics for chronic rhinosinusitis
… are saline nasal irrigation and topical corticosteroids, with the addition of courses of systemic antibiotics and corticosteroids when indicated. If these therapies do not yield a satisfactory improvement in symptoms, functional endoscopic sinus surgery (FESS) may be performed, with …
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Effect of Cigarette Smoke Exposure on Bronchial Hyperresponsiveness in Mice and Response to a Corticosteroid and/or a β2-Adrenergic Agonist and Effect of Cigarette Smoke Extract on Cytokines Release from U937 Cells.
… 126,000 US deaths were attributed to COPD. |Corticosteroids and/or β2 adrenergic agents are the main line of therapy for both asthma and COPD. However, some people with asthma, and the majority with COPD show diminished response to corticosteroid therapy. Various factors such as an increase …
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