Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 84 for “"corticosteroid"”.
-
Corticosteroid hormone action in the cardiovascular system
… (CVS) has emerged as an important target of corticosteroid hormones. Mineralocorticoid receptor antagonists provide cardiovascular protection and are now routinely used in disorders such as primary hyperaldosteronism, resistant hypertension and congestive heart failure (CHF) but the …
-
Corticosteroid-induced morbidity in asthma: costs and consequence
… in asthma and recent evidence has implicated corticosteroids, a cornerstone of treatment, in induced morbidity. The question of how much of the asthma burden can be avoided involves a consideration of the competing harms.<br/><br/>This thesis aims firstly to explore the evidence regarding the …
-
Personalising Inhaled Corticosteroid Dose Response in Persistent Asthma
… thesis examines the overarching theme of inhaled corticosteroid (ICS) dose response effects on a variety of asthma outcome measures; with further importance placed on the application of these findings to personalising ICS dosing for the individual asthmatic.<br/><br/>The introduction provides a …
-
Subacromial bursa injection of corticosteroid on hemiplegic shoulder pain
어깨 통증을 갖고 있는 뇌졸중 환자에서 이학적 검사와 초음파 검사를 이용하여 어깨 관절주위 질환을 진단한 후 견봉하 점액낭 내 스테로이드 주사(트리암시놀론 40mg)를 시행한 결과 통증 및 환자가 느끼는 장애 정도에 호전이 있었으며 어깨관절의 능동적 운동범위, 특히 전방굴곡과 외회전의 운동범위에 호전이 있었으며 특별한 부작용 발생 없이 주사 후 8주까지도 효과가 지속되었다. 이러한 결과는 어깨 통증에 대한 스테로이드 주사 치료 시 치료 효과, 경과 및 지속시간을 추정하는 데에 구체적인 지침을 제공할 수 있을 것이다.
-
Long-term impacts of antenatal corticosteroid exposure and preterm birth
Antenatal corticosteroids are recommended for women at risk of preterm birth before 35 weeks’ gestation for reducing the significant neonatal morbidity and mortality caused by preterm birth. The long-term impacts of both preterm birth and antenatal corticosteroids are incompletely understood. The …
-
Reduced corticosteroid sensitivity in smokers with asthma: potential mechanisms and treatment
… reduced responses to both inhaled and oral corticosteroids with associated increased symptoms, accelerated decline in lung function and increased use of health care services. Little work has been undertaken to address the possible causes of this reduced response and to find effective …
-
A study of selected antineoplastic, antibiotic, and corticosteroid drugs in intravenous admixtures
<p>The benefits of intravenous therapy have become more and more apparent over the years. Medications can be given rapidly with an expectant rapid onset of action. The response to the drugs or fluids can often be closely controlled by regulating the dose or rate of administration. Frequently, …
-
Corticosteroid receptor dynamics and smolting in hatchery-reared and wild coho salmon (Oncorhynchus kisutch)
Seasonal changes in corticosteroid receptors (CR) in the gills of coho salmon (Oncorhynchus kisutch) were examined to determine what effect smolting and rearing environment had on gill tissue sensitivity to cortisol. CR concentration and affinity were found to change seasonally with the increases …
-
Corticosteroid-Encapsulated Nanoparticles in Thermoreversible Gels for the Amelioration of Choroidal Neovascularization in Age-Related Macular Degeneration
… delivery. We prepared stable and reproducible corticosteroid-encapsulated nanoparticles in thermoreversible gels to inhibit vascular endothelial growth factor (VEGF) overexpression characteristic of neovascular AMD. We characterized the drug delivery system by obtaining size, shape, and drug …
-
Do Statins Improve Outcomes in Patients With Asthma on Inhaled Corticosteroid Therapy? A Retrospective Analysis of the Mississippi Medicaid Database 2002-2004.
… to which the subject had at least 1 inhaled corticosteroid (ICS) prescription and at least an 80% adherence rate to statins. Medicaid beneficiaries identified as asthmatics and on ICS therapy, but not on statins were selected as the unexposed population. Each subject in the exposed group was …
-
Regulation of elements of the thyroid hormone and corticosteroid systems by stress, hormone treatment, and atrazine during ontogeny of red drum (Sciaenops ocellatus)
… of elements of the thyroid hormone (TH) and corticosteroid (CS) systems in red drum (Sciaenops ocellatus). Basal cortisol production was first detected 3 days post-hatch (DPH) and a cortisol stress response was present from 6 DPH forward. Changes in steroidogenic enzyme mRNA (CYP11B and …
-
Symptoms and aspects on eosinophil activity in allergic rhinitis
… symptom-reducing effects of a topical corticosteroid. Preceding observations suggest that ß2-agonists may be treatment candidates for allergic inflammation. Utilizing the above-mentioned allergen challenge model, we examine whether or not a topical ß2-agonist (formoterol) affect …
-
The relationship between elevated night-time Glucocorticoid activity and dreaming: a perspective on sleep-dependent memory consolidation
… both during wakefulness and during sleep. Corticosteroid exposure is associated with changes in endogenous glucocorticoid activity, sleep disruption, episodic memory impairment, and reduced hippocampal volume. This dissertation had two primary aims. The first was to explore the relationship …
-
Corticosteroid Induced Alkaline Phosphatase: Cellular Location, Biochemical Characterization and Comparison to Intestinal Alkaline Phosphatase of the Dog (Amino Acid, Monoclonal Antibody, Peptide Mapping, Carbohydrate, N-Terminal)
… was to identify the subcellular location of the corticosteroid-induced isoenzyme of alkaline phosphatase (SIALP) in the liver, purify the SIALP, the intestinal isoenzyme of alkaline phosphatase (IALP) and the hepatic isoenzyme of alkaline phosphatase (LALP), develop an effective means of …
-
Novel approaches to evaluate osteoarthritis in the rabbit lateral meniscectomy model
… a lateral meniscectomy. The 3 groups were: corticosteroid administration, forced exercise and surgical control. An open field maze was used to assess mobility weekly. The rabbits were euthanitized 47 days after surgery. Histopathologic examination found that the lateral meniscectomy induced …
-
Is multimodal care effective for the management of patients with soft tissue injuries of the shoulder? A systematic review of the literature
… outcomes as sham therapy, shock-wave therapy, corticosteroid injections and surgery. For rotator cuff tendinitis, a multimodal program (acupuncture, dietary advice, and enzyme tablets) is more effective than conventional care (supervised exercise, soft tissue therapy, manual therapy, and …
-
Characterization of Rapid Nongenomic Cortisol Signalling in Rainbow Trout Liver
… cortisol is characterized by activation of the corticosteroid receptors, glucocorticoid receptor (GR) and mineralocorticoid receptor (MR), whereas the nongenomic cortisol response involves rapid changes to downstream second-messenger signalling cascades independent of gene regulation. However, …
-
Effect of Cigarette Smoke Exposure on Bronchial Hyperresponsiveness in Mice and Response to a Corticosteroid and/or a β2-Adrenergic Agonist and Effect of Cigarette Smoke Extract on Cytokines Release from U937 Cells.
… 126,000 US deaths were attributed to COPD. |Corticosteroids and/or β2 adrenergic agents are the main line of therapy for both asthma and COPD. However, some people with asthma, and the majority with COPD show diminished response to corticosteroid therapy. Various factors such as an increase …
-
A description of the pharmacokinetics of first line anti-tuberculosis drugs and adjunctive corticosteroid therapy in the pericardial compartment and their effect on cytokine profiles in the pericardial compartment of patients with tuberculous pericarditis
… to this elevated mortality. Adjunctive corticosteroid therapy with prednisolone, has been shown to reduce the incidence of constrictive pericarditis by more than 50%. However, this is associated with significant side effects, especially in patients with HIV co-infection. Constrictive …
-
Exploring the Glucocorticoid Actions of 1α-Hydroxycorticosterone (1α-OH-B) in the Elasmobranch Fishes
<p>The corticosteroid 1α-hydroxycorticosterone (1α-OH-B) is unique to the elasmobranch fishes. It is thought that 1α-OH-B acts as both the primary glucocorticoid (GC) and mineralocorticoid (MC) in these fishes, a dual role analogous to that of cortisol in the teleost fishes. The MC characteristics …
Page 1 of 5