Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 11 of 11 for “"corticogenesis"”.
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A Reductionist Approach to Modeling Human Corticogenesis
… generation of various progenitor types, and 3) corticogenesis. Our current understanding of the molecular and cellular basis of cortical development comes largely from mouse studies due to the genetic tractability of this model system. However, as primate studies have shown, the primate brain is …
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Complex Regulation of Pax6 Neuronal Progenitors By Rb Family Members During Corticogenesis
… family member represses the Rb promoter during corticogenesis, we generated RbP-LacZ lines in genetic backgrounds deficient in various Rb family members and looked for deregulation of RbP-LacZ activity within the embryo (Aim 1). Surprisingly, RbP-LacZ activity responds in opposing ways with …
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PRC2 GATEKEEPS THE BALANCE BETWEEN DIRECT AND INDIRECT NEUROGENESIS AND CONTROLS NEURONAL MIGRATION DURING HUMAN CORTICOGENESIS
Weaver syndrome (WVS) is a rare, autosomal dominant multisystem disorder, characterized by pre- and post-natal overgrowth, macrocephaly, facial dysmorphisms and varying degrees of intellectual disability. WVS’ genetic cause was identified in heterozygous mutations in Polycomb repressive complex 2 …
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Spatial and temporal regulation of cerebral cortex development by the transcription factor pax6
… expressed in apical progenitors (APs) throughout corticogenesis in a rostro-lateralhigh to caudo-mediallow gradient. The current studies focus on elucidating the spatial and temporal role of Pax6 in cortical development. I first analysed the cortex of PAX77 transgenic mice that overexpress Pax6 in …
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Regulation of Notch Ligands Dll1 and Jag1 by Pax6 during cortical development
… and consequently plays a critical role during corticogenesis. Our work aims to identify the regulatory relationship between Pax6 and Notch ligands Dll1 and Jag1 during cortical development. Analysis by flow cytometry and double labelling analysis of both gene and protein expression has provided …
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Molecular Mechanisms Controlling the Development and Evolution of the Human Cerebral Cortex
… derived models of human and non-human primate corticogenesis has revolutionised the study of human cortical development, enabling the characterisation of cell-autonomous developmental mechanisms, comparative studies with more closely related species, and experimental testing of hypotheses on …
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BRAIN ORGANOIDS AS MODELLING CONDUITS OF HUMAN NEURODIVERSITY: ADVANCED COMPUTATIONAL APPROACHES TO SINGLE CELL TRANSCRIPTOMICS
… their longitudinal adherence to in vivo corticogenesis. I leveraged this multi-genotype design to explore interindividual variability in neuronal migration, a process that is particularly relevant to cortical expansion and layering. Moreover, to tackle the need for more granular modelling …
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THE EVOLUTION OF THE MODERN CONDITION THROUGH THE LENS OF NEURODEVELOPMENT DIVERSITY: INSIGHTS FROM A PARADIGMATIC REWIRING OF GENE REGULATION
… HFVs with enhancers active during early corticogenesis to define cortical regulatory islands. By computing allele-specific transcription factor binding affinities at each HFV within cortical regulatory islands, we classified each motif instance as lost, gained, affinity-decreased, …
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INVESTIGATING THE ROLE OF FEZ1 IN EARLY HUMAN BRAIN DEVELOPMENT USING CEREBRAL ORGANOIDS
Perturbations in quantity and localization of multiple neuronal cells generated from progenitors during early cortical development contribute to neuropsychiatric disorders. Genetic interventions are known to cause these disorders but underlying mechanism remains unclear. Human FEZ1 gene is …
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Functional analysis of transcription factor mScrt2 in cortical neurogenesis
Der Neokortex ist eine für das Säugerhirn spezifische Struktur, die schichtartig das Vorderhirn umschließt. Er zeichnet sich durch eine enorme Zellvielfalt aus, die aus der räumlich-zeitlich koordinierten Generierung mehrerer neuronaler und glialer Zelltypen hervorgeht. Die Mehrheit aller …
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DECODING CELLULAR AND TEMPORAL VARIABILITY IN HUMAN CORTICAL DEVELOPMENT. INTEGRATING SINGLE-CELL TRANSCRIPTOMICS ACROSS DEVELOPMENTAL STAGES AND EXPERIMENTAL MODELS.
The human cortex is composed of heterogeneous neurons and glia that interact to facilitate complex brain functions. However, studying their development over decades has been technically challenging due to limitations in data access and representation. Recent advances in single-cell profiling have …