Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 8 of 8 for “"cortical progenitors"”.
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Removal of Pax6 from cortical progenitors renders them abnormally likely to switch fate in response to Sonic Hedgehog activity
… In mice, it is expressed by neural progenitors in the cortical ventricular zone (VZ) where it regulates neurogenesis and fate specification. The complex processes of neurodevelopment are also regulated by morphogens such as Sonic Hedgehog (Shh) that promotes ventralization of the …
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Spatial and temporal regulation of cerebral cortex development by the transcription factor pax6
… generation, migration and differentiation of cortical neurons. Cortical projection neurons originate from progenitors of the embryonic dorsal telencephalon. The transcription factor Pax6 is expressed in apical progenitors (APs) throughout corticogenesis in a rostro-lateralhigh to …
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Gli3 regulates the proliferation and differentiation of progenitors in the developing neocortex
… species, in part due to the massive expansion of cortical progenitors during embryonic development. The mature cortex of mammals is composed of a highly heterogenous population of cells, however only the glutamatergic projection neurons are generated within the embryonic neocortex itself. These …
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Proneural Genes in Neocortical Development
The timing of neocortical development is regulated by both intrinsic proneural genes Neurog2 and Ascl1, and extrinsic signals. However, how these intrinsic factors and extrinsic signals coordinatedly control neural cell fate decisions was not well understood at the start of my studies. Neurog2 and …
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Developmental origins of cortical circuit dysfunction in a 22q11 deletion mouse model
Cortical circuit development is tightly regulated by programs of progenitor proliferation, neurogenesis, and neuronal maturation. Disruptions in these processes contribute to the cortical circuit pathology observed in neurodevelopmental disorders such as schizophrenia and autism, intellectual …
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Molecular Mechanisms Controlling the Development and Evolution of the Human Cerebral Cortex
… and human-specific changes in the patterns of cortical progenitor proliferation and differentiation during development. The relative inaccessibility of human and primate cortical development has however hindered the study of the molecular mechanisms which underly it and are responsible for …
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Transcriptional Regulation of Neuronal Fate Specification by Proneural Genes in the Developing Neocortex
… determinants that control the timing of cortical neurogenesis are the proneural basic helix-loop-helix (bHLH) transcription factors encoded by Neurog1, Neurog2, and Ascl1. The activities of these proneural genes are tightly regulated, ensuring that neocortical neurons are born at their …
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Genomic Instability and the Oncohistone H3K27M Drive Gliomagenesis in a Murine Model
… repair factors that prevent tumorigenesis during cortical development. We have compared the differential effects of inhibition of homologous recombination (HR), via BRCA2-inactivation and non-homologous end-joining (NHEJ), via LIG4-inactivation towards tumorigenesis by directing their deletion …