Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 13 of 13 for “"cortex development"”.
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Spatial and temporal regulation of cerebral cortex development by the transcription factor pax6
Lamina formation in the developing cortex requires precise generation, migration and differentiation of cortical neurons. Cortical projection neurons originate from progenitors of the embryonic dorsal telencephalon. The transcription factor Pax6 is expressed in apical progenitors (APs) throughout …
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fMRI for mapping the plastic somatotopy of primary somatosensory cortex - Development and clinical applications
… for fMRI mapping of the primary somatosensory cortex (S1) are optimised and subsequently applied in studies where a plastic reorganisation of S1 is hypothesised. Initially, the impact of spatial resolution and smoothing on fMRI data of detailed S1 activation was investigated using a theoretical …
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Single cell transcriptomic analysis of autism associated gene expression in human cerebral cortex development
Autism spectrum disorder (ASD) is a range of developmental brain disorders characterized by poor nonverbal communication skills, impaired behaviour and social interaction, and a limited diversity of social activities and interests. As the most common pervasive developmental disorder, it affects …
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Tyrosine hydroxylase immunoreactive fibers in the upper layers of the adolescent rat medial prefrontal cortex
… the brain. In particular, the medial prefrontal cortex continues developing throughout adolescence and is responsible for a number of executive and cognitive functions. Innervation of the medial prefrontal cortex by the dopaminergic system contributes to some of these maturing behaviors and the …
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DECODING CELLULAR AND TEMPORAL VARIABILITY IN HUMAN CORTICAL DEVELOPMENT. INTEGRATING SINGLE-CELL TRANSCRIPTOMICS ACROSS DEVELOPMENTAL STAGES AND EXPERIMENTAL MODELS.
The human cortex is composed of heterogeneous neurons and glia that interact to facilitate complex brain functions. However, studying their development over decades has been technically challenging due to limitations in data access and representation. Recent advances in single-cell profiling have …
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THE INTERPLAY BETWEEN ENDOCRINE DISRUPTION AND GENETICS IN THE PHYSIOPATHOLOGY OF HUMAN NEURODEVELOPMENT: BRIDGING EPIDEMIOLOGY TO MOLECULAR INSIGHTS THROUGH BRAIN ORGANOIDS AND HIGH RESOLUTION OMIC MODELLING
… pre- and postnatal exposure to EDCs and impaired development of cognitive functions, attention and social behaviors in children. Nonetheless, the molecular mechanisms underlying such outcomes are yet to be detailed and EDC-induced DNT (developmental neurotoxicity) remains largely uncovered by the …
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Anatomical identification of primary auditory cortex in the developing gerbil
Cortical development is an active field of study. The gerbil provides an excellent model for research because at the moment of birth its brain is rather immature, anatomically and functionally. Furthermore, the gerbil auditory cortex is particularly amenable to investigation in that the gerbil's …
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The Role of CNTNAP2 in the Development & Evolution of the Human Cerebral Cortex
… by species-specific features of their development. Excitatory neurons in the human cerebral cortex have longer neurites and more elaborate neurite branching than chimpanzees or macaques, which is thought to contribute to differences in neural network performance. To study how …
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The Epigenetic Role of EGR1 during Postnatal Mammalian Brain Development
… is an epigenetic mechanism critical for tissue development, cell specification and cellular function. Mammalian brains consist of millions to billions of neurons and glial cells that can be subdivided into many distinct types of cells. We hypothesize that brain methylomes are heterogeneously …
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Role of Laminin gamma 1 in Cortical Development
… in the nervous system. These mice show cortical developmental abnormalities including undulations in the embryonic cortical plate and resultant adult cortical layers and abnormal positioning of pyramidal neurons and interneurons. We have investigated the mechanisms underlying these abnormalities. …
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Molecular and Functional Characterization of TrkC Alternative Splicing Regulation and its Impact on the Fate Acquisition of Cortical Projection Neurons
… and finely tuned neuroanatomy of the cerebral cortex motivates sustained research efforts on the mechanisms that give rise to this intricate tissue. To enable the higher cognitive functions of mammals, various subtypes of cortical projection neurons, distributed in precise ratios and at …
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The Brains of Babies: A Surface Based Approach To Study Cortical Development in Term and Preterm Human Infants
… we improve our understanding of normal cortical development and develop tools to evaluate injury. Using a surface based approach we have characterized normal cortical development in healthy term infants and analyzed abnormalities associated with preterm birth. Accurate cortical surface …