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Showing 1 to 17 of 17 for “"coronary stents"”.
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A system for impedance characterization of coronary stents
Stents are used to re-open and maintain flow in diseased coronary arteries in patients suffering from coronary heart disease. Drug-eluting stents are now the preferred choice of stent but their performance is still limited by delayed healing of the important endothelial cell layer that lines the …
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Developing polypyrrole coated coronary stents for extended release of Sirolimus
Coronary heart disease remains the biggest killer worldwide. Amongst all the treatment options, drug-eluting stents (DES) are thought to be the most effective method of treatment for the majority of patients. Despite the early success of DES in treating coronary artery disease, concerns and …
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Modeling and simulation of coronary stents: Intravascular drug delivery and arterial drug distribution
In-stent restenosis still occurs in coronary arteries implanted with drug-eluting stents, with the maximum thickness observed at the vascular site of maximum inter-strut angle. This phenomenon may be related to the specific spatiotemporal drug uptake in the arterial wall. In this work local …
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Controlling the alignment and degradation of 3D printed poly-L-lactic acid for redesigned coronary stents
Cardiac stents are used for treating heart disease, widening the blocked artery to restore normal blood flow. However, most stents are permanent. This posits several problems, including the long-term risk of restenosis and thrombosis. Consequently, significant research is focused on creating …
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Comparing long-term antiplatelet strategies to prevent morbidity and mortality in patients with drug-eluting coronary stents
Background: The optimal long-term antiplatelet therapy (APT) that balances the benefit of preventing myocardial infarction (MI) with the risk of severe bleeding is unknown in patients greater than one year after drug-eluting stent (DES) placement. Methods: We modeled life expectancy (LE) using …
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Experimentelle Untersuchungen am porzinen „over-sized coronary stent“-
… investigations at the porcine over-sized coronary stent-model for in-stent-restenosis rate after implantation of uncoated niob-zirkonium stents and niob-zirkonium stents coated with iridiumoxide. Background: The treatment of atherosclerotic stenosis in coronary artery disease with balloon …
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Development of bioabsorbable braided vascular scaffolds for the intracranial circulation
… procedure. Despite these improvements, metal stents are still associated with major complications, mostly due to their thrombogenicity as well as their long-term implications. Although the need for a stent to treat aneurysms is only temporary, due to progressive neointima formation over the …
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Market application of a novel stent-based patency monitor to the management of ischemic vascular disease
The use of stents following angioplasty in ischemic arterial beds is limited by complications and continuing vascular deterioration. A phenomenon called stent restenosis post procedure exists which puts patients at a relatively high risk for vessel stenosis and occlusion. Stent restenosis may …
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Construction of nano-assembled microcapsules embedded with gold nanoparticles for use in novel drug delivery systems
Coronary stents have changed the way in which coronary artery diseases are managed. Although bare-metal stents can be traced back to 1994, long term efficacy of these stents has been shattered by ISR (In-Stent restenosis) and late stent thrombosis. Research on finding a solution to these issues has …
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A Nondimensional Scaling Parameter for Predicting Pressure Wave Reflection in Stented Arteries
Coronary stents have become a very popular treatment for cardiovascular disease, historically the leading cause of death in the United States. Stents, while successful in the short term, are subject to high failure rates (up to 24% in the first six months) due to wall regrowth and clotting, …
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Studies of Stented Arteries and Left Ventricular Diastolic Dysfunction Using Experimental and Clinical Analysis with Data Augmentation
… Shear Index (OSI) caused by the implantation of coronary stents into the arteries of the heart using Particle Image Velocimetry. These experiments featured one-to-one scaling, commercial stents, and realistic flow and pressure waveforms, and are believed to be the most physiologically accurate …
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Polymer based microscale and nanoscale technologies for optical and biomedical application
… for its potential application in biodegradable coronary stents. We fabricated the stents by rolling the PLLA films into the tube. The controlled drug release was studied by releasing the control and patterned PLLA surface into phosphate buffer saline. We used advanced high performance liquid …
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Development and evaluation of the manufacture of a coronary stent for the South African market
The need for economic treatment of coronary heart disease in South Africa and the popularity of coronary stent implantation as an effective treatment increases. Stent implants have had to be imported to date with significant cost involved. The project in hand therefore deals with the evaluation of …
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A combined experimental and computational framework to optimise processing and design of poly(L-lactic acid) bioresorbable stents
Coronary heart disease, caused by inflammatory hardening and narrowing of arteries (atherosclerosis) is the largest cause of death in the world. Coronary stents, used to treat atherosclerosis, are typically manufactured from high strength metallic alloys; however such devices remain in the body …
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Promoting endothelialisation to reduce vascular injury following coronary angioplasty and stent implantation
… patients undergoing angioplasty and stenting for coronary artery disease. I sought to establish a new cellular model to study the coronary endothelium in patients with acute myocardial infarction, and to utilise this model to identify novel polymer substrates that promote endothelialisation of …
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Novel positron emission tomography applications for imaging cardiovascular disease activity
… explored in a wide range of conditions including coronary atherosclerosis, aortic stenosis and bioprosthetic valve disease, offering a marker of vascular injury and disease activity in each condition studied. At the moment, we lack reliable and reproducible methods for predicting myocardial …