Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 23 for “"corepressor"”.
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Transcriptional functions of the corepressor Sin3A in skin
Upon activation in epidermal stem cells, the proto-oncogene c-Myc triggers their exit from the stem cell compartment resulting in an increase in progenitor cell proliferation and an induction in terminal differentiation. Whether c-Myc plays a direct transcriptional role in epidermal stem cell …
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BTK functions as a corepressor of Nurr1 in human neural stem cells
Nurr1이 TH 유전자의 발현을 조절할때 세포의 분화정도에 따라 새로운 cofactor를 유도하여 complex를 형성하게되는데 미분화신경줄기세포에서는 BTK를 분화세포에서는 PARP를 유도한다.
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Multiple Functions of BRD4 in E2 Mediated HPV Transciptional Regulation
… protein 4 (Brd4) as a cellular corepressor for E2-mediated inhibition of HPV transcription. Brd4 contains two bromodomains which function as acetyl-lysine-binding modules that facilitate chromatin targeting via their interactions with acetylated histones. Although Brd4 has been …
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Role of Abberant Proteolysis in the Pathogenesis of APL
… promotes misfolding of nuclear hormone receptor corepressor (N-CoR) and that accumulation of misfolded N-CoR in the ER induces endoplasmic reticulum (ER) stress and activates unfolded protein response (UPR). Although accumulation of misfolded proteins is known to trigger UPR-induced cytotoxic …
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A Novel Protective Role for p130 in Neuron Oxidative Stress
… genome by the nuclear transcriptional corepressor p130. This might serve as a potential mechanism to control ROS production of neurons in response to increased metabolic stress.
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Regulation of Secretory Phospholipase A2 by Thyroid Hormone
… present studies, I found that disruption of the corepressor binding site in TRβ decreased the T3 inhibition of PLA2g2a. Conversely a mutation in coactivator binding site had no effect on the T3 mediated inhibition of PLA2g2a. Knockdown of nuclear corepressor (NCoR1) or silencing mediator for …
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Nitrogen Fixation By Azotobacter Species In Mixed Culture
… endproduct of nitrogen fixation, acts as a corepressor of nitrogenase synthesis. It has also been shown that ammonia will accumulate in the medium of pure cultures of Azotobacter vinelandii until levels become high enough to repress nitrogenase synthesis. A. vinelandii and A. chroococcum …
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Synthesis of cis- and trans-3-fluoroacrylate, and inhibition of BCL6 targeting a non-reactive cysteine
… and irreversibly modify a cysteine within the corepressor peptide binding site in the BTB-domain of BCL6. Irreversible inhibition will block its function. These inhibitors are potential therapeutics for treating diffuse large B-cell lymphomas (DLBCLs) and triple negative breast cancers that are …
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Epigenetic Regulation of Nuclear Hormone Receptor DAX-1
… congenita. DAX-1 has been observed to act as a corepressor of other nuclear receptors including androgen receptor (AR), estrogen receptor (ER), and steroidogenic factor 1 (SF-1). In addition to pluripotent ES cells, DAX-1 is primarily expressed in select tissues of the body such as testes, …
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Characterisation of the leukaemia-associated ETO homologues
… ETO homologues, but not AML1-ETO can bind to the corepressor SIN3B. The proposed interactions of the ETO homologues might have implications for the onset of leukaemia, since it opens up for an AML1-ETO mediated disturbance of ETO homologue function as well as a regulation of AML1-ETO function by …
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PLASTICITY IN PROTEIN SEQUENCE-FUNCTION RELATIONSHIPS
… were characterized for their roles in the corepressor-induced dimerization. The study of nonconserved amino acid positions spanning these surface loops reveals that a broad range of functional response in dimerization and transcription repression can be achieved by sequence variations at …
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Large-scale studies and biophysical analysis of systems involved in plant immunity.
… TGA recruits a specific novel glutaredoxin as a corepressor to dampen the expression of a set of SAR-regulated genes controlled by salicylic acid (SA) and the SAR-orchestrator, NPR1. Finally, we demonstrated that NPR1 binds SA and that this interaction leads to the destabilization of NPR1. More …
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Analysis of senescence-like growth arrest induced by RUNX1 and its fusion derived oncoproteins
… mutant RUNX1-ETO[]469 which lacks critical corepressor binding sites suggesting that the repression of target genes may be a primary mechanism implicated in RUNX1-ETO induced senescence. Interestingly, CBFB-MYH11 fusion oncoprotein that affects RUNX1 indirectly by targeting CBFB cn also …
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Regulation of mammalian SINE transcription
… also found to be occupied by components of two corepressor complexes, SIN3 and NuRD. Whether MBD proteins repress SINE transcription in a DNA methylation-dependent manner was further investigated using systems with low or near absent DNA methylation and, in the case of MeCP2 protein, by its …
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Generation and Characterization of a Knock-In Allele of EKLF: Probing the in vivo Role of the Chromatin Remodeling Domain in Definitive Hematopoietic Cells
… promoter; iii) recruitment of a Sin3A-containing corepressor complex to the <a></a>Fli-1 promoter. Taken together, my results suggest strongly that the unique D221EKLF domain is sufficient to modulate the chromatin-specific roles of EKLF at erythroid- and megakaryocytic-specific loci in definitive …
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Structure-function analysis of the essential islet regulatory factor Nkx2.2
… targets. It has also been demonstrated that the corepressor Grg3 is expressed in the endocrine population and can physically interact with Nkx2.2, which points toward a mechanism by which Nkx2.2 confers transcriptional repression; however, the genes targeted by Nkx2.2/Grg3 are unknown. …
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Investigating novel direct Notch targets in Drosophila neural stem cells
… of target genes, which are silenced by the Su(H)-corepressor complex in the absence of Notch activity. The functions of Notch are very context-dependent, making it important to identify the Notch regulated genes in different processes. Neural stem cells (NSCs) are cells that can divide and …
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Regulation of the potential tumorsuppressor gene mad1 by G-CSF
… and by recruiting histone deacetylase-containing corepressor complexes. However, little is known about the regulatory mechanisms that control the expression of the mad1 gene. The aims of the study were to investigate the transcriptional regulation of the mad1 gene. In particular, we would like to: …
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Biochemische Charakterisierung der basischen Helix-Loop-Helix-Transkriptionsfaktoren Hey1 und Hey2 sowie Untersuchung ihrer Rolle während der Herz- und Gefäßentwicklung
… zu den übrigen hairy-Proteinen, nicht mit dem Corepressor Groucho/TLE1 interagieren. Electrophoretic Mobility Shift Assays ergaben, dass die Hey1- und Hey2-Proteine an eine E(spl)-spezifische E-Box DNA-Sequenz (CACGTG) binden. Auch die interagierenden bHLH-Proteine c-hairy1, E2-2 und E2-5 …
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Characterization of the Mechanism of PPARγ-Mediated Neointima Formation in Rodents
… through stabilizing its interaction with the corepressor SMRT. CPA production inhibits the PPAR! target-gene transcription that normally drives adipocytic differentiation of 3T3-L1 cells, lipid accumulation in RAW264.7 cells and primary mouse macrophages, and arterial wall remodeling in vivo. …
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