Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 47 for “"core protein"”.
-
HCV Core Protein affects Lipid Metabolism in a Genotype-Dependent Manner
… with more severe disease. It is known that core protein plays a role in the development of steatosis, but the precise mechanism is not yet understood. In this study, we investigate the role of genotypes in core-mediated differential regulation of lipid metabolism. Prior studies described the …
-
HCV Core Protein affects Lipid Metabolism in a Genotype-Dependent Manner
… with more severe disease. It is known that core protein plays a role in the development of steatosis, but the precise mechanism is not yet understood. In this study, we investigate the role of genotypes in core-mediated differential regulation of lipid metabolism. Prior studies described the …
-
Functional Role of Hepatitis B Virus Core Protein in Viral Replication
… nucleic acid binding domain of HBV core protein for hepatitis B virus (HBV) replication, chimeric HBV core proteins were generated by substituting varying lengths of the carboxyl-terminus of duck hepatitis B virus (DHBV) core protein for the corresponding regions of HBV core protein. …
-
T-cell Dysfunction by HCV Core Protein Involves PD-1/PD-L1 Signaling.
… healthy donors when exposed to extracellular HCV core protein (a nucleocapsid protein that is immunosuppressive); upregulation of PD-1 is mediated by core's ability to bind to the complement receptor gC1q. We also report that the observed T-cell function can be restored by blocking the PD-1/PDL-1 …
-
DEFINING THE ROLE OF LIPID DROPLET SCAFFOLDING PROTEINS IN HEPATIC STEATOSIS INDUCED BY HEPATITIS C VIRUS CORE PROTEIN
Hepatitis C Virus (HCV) is an enveloped RNA virus responsible for 170
-
Identification of hepatitis C virus core protein residues critical for the interaction with the cellular DEAD-Box Helicase DDX3 and their functional relevance
… classified as a major human pathogen. HCV core protein is believed to form, by analogy with other members of the Flaviviridae family, the nucleocapsid of the virus. As well as this, core has been shown to modulate many cellular processes via interactions with numerous host-cell proteins. …
-
Initial Stages of Hepatitis B Virus Replication
PART 1 Intracellular Trafficking of HBV Core Particle in Various Stage of DNA Replication Inside of hepatitis B virus (HBV) core particle, pgRNA is reverse transcribed by HBV DNA polymerase into minus-strand DNA and pregenomic RNA (pgRNA) is degraded concomitantly by RNase H activity of DNA …
-
Critical C-termical Amino Acids of Hepatitis B Virus Core Proteins for HBV Replication
… 가지고 있으며, 4개의 open reading frame (ORF)으로부터 core protein, surface protein, DNA polymerase, X protein을 발현한다. HBV core protein은 183개 또는 185개의 amino acid로 구성되어있는 22kDa의 단백질이며, HBV core protein은 pgRNA 의 encapsidation 및 DNA 합성에 관여하는 것으로 알려져 있다. HBV core protein은 기능적으로 두 부위로 나뉜다. core particle 조립에 …
-
Molecular Mechanisms of Hepatitis C Virus- Associated Steatosis
… steatosis. Research suggests a role for the core protein of HCV, which forms the capsid of the virus, in the alteration of lipid metabolism pathways during infection. As such, I hypothesized that: 1) HCV alters lipid metabolism pathways and causes the build up of lipid in hepatocytes and the …
-
Probing nanomechanics of aggrecan and the aggrecan-rich pericellular matrix of chondrocytes in cartilage
… (CS-GAG) chains attached covalently to a core protein. Electrostatic interactions between these GAGs contribute to the compressive and shear stiffness of the tissue. Variations in the structure of aggrecan and its GAG constituents are known to exist as a function of tissue age, disease, …
-
Ultrastructure and nanomechanical properties of aggrecan from native cartilage and engineered tissue
… The bottle-brush-shaped aggrecan consists of a core protein to which ~100 sulfated glycosaminoglycan (sGAG) chains are attached. Loss of sGAG is one early events in the pathogenesis of osteoarthritis and the resulting degradation of cartilage is irreversible due to its limited capacity for …
-
Fluorous assisted one-pot oligosaccharide synthesis and chemical synthesis of homogeneous heparan sulfate proteoglycan
… sulfate (HS), tetrasaccharide linkage and core protein and increasing evidence shows both HS and core protein can direct the function of HSPGs. To establish structure-activity relationship, it is important to obtain homogeneous HSPGs. However, naturally existing HSPGs are higly …
-
Genetic and Biochemical Analyses of the Flaviviridae Capsid Proteins
… thought to arise by budding of the capsid protein and associated genomic RNA through a host cell-derived lipid membrane outfitted with envelope glycoproteins. The process of virion morphogenesis is not well understood, but the presumed involvement of numerous viral and cellular components …
-
Structural and Biochemical Characterization of N-Terminal Protease of Classical Swine Fever Virus
… that is subsequently cleaved into individual proteins by host- and virus-encoded proteases. N-terminal protease Npro is the first translated protein of the pestivirus genome. Npro is a cysteine auto-protease that cleaves between its own C-terminus (Cys168) and the N-terminus of the core …
-
Self-assembling peptide hydrogels promote in vitro chondrogenesis of bone marrow-derived stromal cells : effects of peptide sequence, cell donor age, and method of growth factor delivery
… than young chondrocytes. Measurement of aggrecan core-protein and chondroitin-sulfate length by atomic-force microscopy revealed BMSCs produce longer core protein and chondroitin-sulfate, and fewer catabolic-cleavage products than chondrocytes. Therefore, BMSC-produced aggrecan appears to have a …
-
Extracellular Contractile Injection Systems (eCIS) - Characterization of Conserved Phage Tail-like Structures in Streptomyces
… I show that all eCIS are comprised of nine core protein families and are closely related to contractile phage tails, a relationship emphasized by the discovery of rare eCIS-like prophages that are the likely evolutionary link between the two. I classify eCIS into six distinct groups and show …
-
Untersuchungen zu Auswirkungen von GAG-Linkeropathien auf die ECM-Homöstase durch die Generierung von knockout-Modellen in Dermalfibroblasten
… Bindung von Glykosaminoglykanen (GAG) an ihre core-Proteine gebildet. Der Tetrasaccharid-Linker bildet das Bindeglied zwischen dem core-Protein des PGs und der repetitiven Disaccharidkette des GAGs und wird von vier Glykosyltransferasen synthetisiert. Im initialen, geschwindigkeitsbestimmenden …
-
The role of PLK1 in Hepatitis B Virus (HBV) infection of the liver
… Here, I provide a review for the HBV core protein (HBc), its function and the host molecules it usurps during infection and pathogenesis. I also identify Polo-like-kinase 1 (PLK1) as a proviral factor in HBV pathogenesis. I demonstrate by loss of function as well as gain of function …
-
The Role for Proteoglycans in Regulating Embryonic Patterning and Morphogenesis
… Proteoglycans are high molecular-weight proteins consisting of a core protein with covalently linked glycosasminoglycan (GAG) sidechains, which are thought to mediate proteoglycan-ligand interactions. UDP-glucose dehydrogenase (Ugdh) is an enzyme required for the biosynthesis of GAGs, and …
Page 1 of 3