Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 6 of 6 for “"copy number aberration"”.
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Genomic characterization of ETV6/RUNX1-positive acute lymphoblastic leukemia
… present in six cases, was the most common copy number aberration (CNA). A large number of genes was present in the commonly gained region but the high and specific expression of SPANXB identified this gene as a likely target of the gain. In Article II, 24 ALLs were analyzed using 500K …
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Improving earlier non-invasive diagnosis of high-grade serous ovarian cancer
… score, a quantitative measure of genome wide copy number aberration generated from shallow whole genome sequencing (sWGS) data, ctDNA was detected in 39–41% of the women with newly diagnosed disease. To improve sensitivity of ctDNA detection I developed an optimised method for targeted …
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Detection of Novel Genomic Markers for Predicting Prognosis in Hepatocellular Carcinoma Patients by Integrative Analysis of Copy Number Aberrations and Gene Expression Profiles: Results from a Long-Term Follow-Up
… (HCC) prognosis by integrative analysis of DNA copy number aberrations (CNAs) and gene expression profiles. Array comparative genomic hybridization and expression array were performed on 45 and 31 HCC samples, respectively. To identify functionally important genes, concordant results of DNA copy …
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Prognostic Significance of Chromosome 9p Deletion in Clear Cell Renal Cell Carcinoma
The prognostic role of chromosomal copy number aberration in renal cell carcinoma (RCC) has been explored in several studies. Chromosome 9p deletion was reported as an independent prognostic factor in clear cell subtype (ccRCC). The findings from these studies initially appeared promising however …
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Measuring ongoing chromosomal instability in single-cell DNA sequencing data
… status. Cancer cells often exhibit DNA copy number aberrations and can vary widely in their ploidy as a consequence. Correct estimation of the ploidy of single cell genomes is crucial for many aspects of downstream analysis, such as copy number calling and inference of cell phylogenies. …