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Showing 1 to 20 of 31 for “"copper-mediated"”.
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COPPER-MEDIATED N1-ARYLATION OF BENZOTRIAZOLES
<p>Benzotriazoles are group of bicyclic heterocyclic compounds that contain three nitrogen atoms fused to a benzene ring. Along with their derivatives, they possess a wide range of properties. They are used in medical field, as they exhibit such properties as …
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Development of new dendritic ligands for copper mediated Atom Transfer Radical Polymerization (ATRP) of methyl methacrylate
… ligands have been synthesized and used in copper mediated Atom Transfer Radical Polymerization (ATRP) of MMA. These ligands were derived from the commercially available Generation 1 polypropyleneimine dendrimer DAB-(NH2)4. The first set of ligands was synthesized by reacting DAB-(NH2)4 with …
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Nickel-catalyzed cross-couplings of unactivated secondary and tertiary alkyl halides and photoinduced copper-mediated asymmetric C-N cross-couplings
… the establishment of photoinduced asymmetric copper-mediated C-N Ullmann-type coupling processes between racemic secondary alkyl halides and N-heterocycles. Preliminary yields and enantioselectivities for a reaction between secondary benzylic halides and carbazoles, with the use of a …
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C(sp2)–H Functionalizations Employing 2-Aminophenyl-1H-pyrazole as a New Removable Directing Group
… a novel removable bidentate directing group for copper-mediated aerobic oxidative C(sp2)–H bond amidation and sulfonamidation bearing a wide range of sulfonamides, When Cu(OAc)2 was employed as the copper source, 1,1,3,3-tetramethylguanidine (TMG) as an organic base, the reaction, optimally …
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Asymmetrische Synthese und stereoselektive Substitution allylischer Sulfoximin-funktionalisierter Homoallylalkohole
… and high diastereoselectivities. Copper-mediated subtitution in gamma position of the sulfonimidoyl-group furnished the corresponding (E)-configured allylic alcohols in good yields, with complete regioselectivities and high 1,3-chiraltiy transfer.
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Synthesis of new sulfoximines for asymmetric synthesis and pseudopeptides
… by palladium-catalyzed C-arylation, (iii) copper-mediated N-arylation of sulfoximines and (iv) silver-catalyzed or metal-free iminations of sulfoxides to afford sulfoximines.
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Synthese neuartiger Sulfonimidamide zur Anwendung in der asymmetrischen Katalyse
… at the sulfur atom is retained. Moreover, a copper-mediated cross coupling reaction for the preparation of N-arylated sulfonimidamides was developed. The products were obtained in moderate to good yields in the presence of stoichiometric amounts of copper(I) salt, potassium carbonate and …
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The Mechanism of Copper Toxicity in Escherichia Coli
… of this study was to determine the mechanism of copper toxicity. Copper is toxic to both eukaryotes and prokaryotes and is the causative agent of Indian childhood cirrhosis, Tyrolean infantile cirrhosis, and Wilson disease. Studies in eukaryotic systems demonstrated that copper-toxified cells had …
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Iridium-catalyzed borylation of aromatic and aliphatic C-H bonds: methodology and mechanism
… arenes by iridium-catalyzed C-H borylation and copper-mediated cyanation of the resulting arylboronate esters is described in Chapter 2. This process relies on a previously unknown method to conduct the cyanation of arylboronic esters, and conditions for this new transformation are reported. …
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Development of copper-catalyzed enantioselective alkene difunctionalization reactions via radical intermediates
… of unactivated alkenes based on a copper-catalyzed ligand-assisted difunctionalization strategy has been developed. This method provides access to a variety of classes of synthetically useful CF3-containing building blocks from simple starting materials. Chapter 2 A method for the …
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The role of the E2 copper binding domain in the cell biology of the amyloid precursor protein
… soluble APP alpha (sAPPα). APP itself binds to copper at a number of sites, including a recently identified E2 copper binding domain (E2 CuBD) within the extracellular region of the protein. The current project aims were to investigate how copper binding within the APP E2 CuBD might influence …
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Design and synthesis of cyclometalated transition metal complexes as functional phosphorescent materials
… compounds. The robust and tolerant nature of the copper mediated 1,3-dipolar cycloaddition reactions offers great flexibility in the molecular design. Chapter 1 and Chapter 2 focus on the synthesis of heteroleptic cyclometalated Ir (III) and Pt(II) complexes by utilizing the Cu(I) triazolide …
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Design and Synthesis of a Macrocyclic Phospholipid
… to produce a glutarate monoester. Copper-mediated azide-alkyne coupling (CuAAC) using 1,5-diazido-3-oxapentane(bis-azide) afforded a dicarboxylicacid with a hydrophobic chain of sufficient length to span a 35 Å bilayer membrane. The carboxylic acids were each esterified with an …
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Multivalent activation in temporary phosphate tethers: A new tether for small molecule synthesis
… diastereoselective desymmetrization event via copper-mediated allylic alkylation. Studies were extended to include C 2-unsymmetric monocyclic phosphates, in which steric and electronic effects were further probed. In general, the method provided access to both syn- and anti-1,2-homoallylic …
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Surface Modification of Nanoparticles Using Controlled Radical Polymerization For Designed Interfaces
… clicked onto the grafted polymer chains using copper mediated alkyne/azide click reaction.</p>
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Palladium catalysis in the synthesis of polyaniline-related materials
… of palladium, as the palladium source. A new copper-mediated method has been developed for the synthesis of 2- (di-tert-butylphosphino)biphenyl, a versatile ligand developed by Wolfe and Buchwald for palladium-catalyzed cross-coupling reactions, on multigram scale. The use cf this ligand in …
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Acquired copper imbalance in diabetes-induced cardiac disease: Molecular mechanisms and reversibility
… chronic hyperglycaemia can disrupt myocardial copper balance and cause elevated serum copper levels, particularly in those patients with cardiovascular complications. It has also been shown that copper imbalance in the myocardium can be directly or indirectly involved in the pathogenesis of …
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Development of Novel PET Radiotracers for Neuroinflammation and COVID-19: Targeting FPR2, I2BS and ACE2
… A model compound was first employed to test the copper-mediated radiofluorination. An automated radiosynthetic method was developed to afford [18F]BU-5 via an alcohol-enhanced copper-mediated 18F-radiolabelling approach. Radiotracer [18F]BU-5 was produced with d.c.RCYs (decay corrected to the …
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An Inverse Electron-Demand Diels-Alder Strategy for Mapping RNA Methylation
… for RNA analysis, established reactions like the copper- catalysed azide-alkyne cycloaddition (CuAAC) can have disadvantages for modification mapping, including copper-mediated RNA degradation that can compromise data integrity. This highlights a critical need for further biocompatible reactions …
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