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Showing 1 to 9 of 9 for “"copper transporter"”.
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Therapeutic targeting of the ATP7A copper transporter in cancer
[EMBARGOED UNTIL 12/01/2026] Copper (Cu) is an essential micronutrient involved in numerous biochemical processes, including energy production, iron metabolism, cell proliferation, cuproenzyme activity, and collagen crosslinking. Because Cu cannot be synthesized or metabolized by the body, it must …
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Expression and cellular localization of Copper transporter 2 (Ctr2) in Mus musculus
The Ctr family is an essential part of the copper homeostasis machinery and its members share sequence homology and structural and functional features. Higher eukaryotes express two members of this family Ctr1 and Ctr2. Numerous structural and functional studies are available for Ctr1, the only …
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Inhibition of Cysteine Protease by Platinum (II) Diamine Complexes
… in treatment. Cisplatin enters the cell through copper transporter CTR1 by passive diffusion and bind to DNA and proteins. Cisplatin is found to inhibit several enzymes targeting cysteine, histidine and methionine residues, which are expected to be responsible for its anticancer activity. A …
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High Pressure Liquid Chromatography Studies of the Reaction of Platinum Complexes with Peptides
… could actually favor its anticancer activity. Copper transporter 1 (Ctr 1), a protein involved in the transport of copper into the cell, also helps in the influx of cisplatin by binding to N-terminal domain of Ctr 1 which is rich in methionine and histidine residues. A better understanding of …
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Copper at the Interface of Chemistry and Biology: New Insights into hCtr1 Function and the Role of Histidine in Human Cellular Copper Acquisition
<p>Mechanisms of copper homeostasis are of great interest partly due to their connection to debilitating genetic and neurological disorders. The family of high-affinity copper transporters (Ctr) is responsible for extracellular copper acquisition and internalization in yeast, plants, and mammals, …
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Proteinkonjugationen durch Kupfer-abhängige Formylglycin-generierende Enzyme zur Generierung von Antikörper-Wirkstoff-Konjugaten
… As a cofactor of the aerobic enzymes, copper has a great influence on the substrate specificity of the prokaryotic FGE variants. In high enzyme-to-substrate ratios and in the presence of copper the acceptance of the proline-free motif increased. This effect was observed regardless …
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Mechanisms of Accumulation and Biological Consequences of Polynuclear Platinum Compounds
… Similar to cisplatin, BBR3464 v as shown to use copper transporter hCTR1 and ATP7B for influx and efflux respectively. Organic cation transporters (OCT) did not play an important role in BBR3464 cellular uptake, however, desipramine, an OCT inhibitor had synergistic effects on platinun …
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The role of copper in Parkinson's disease
Decreased copper levels has been consistently reported in the degenerating substantia nigra in Parkinson s disease, but the cause, and functional consequences, of this decrease are unknown. This thesis aimed to investigate neuronal copper levels and potential changes in copper transport in the …
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Cellular Copper Import Mechanisms via Secreted Cuproproteins: Exploring Metal Homeostasis in Pseudogymnoascus destructans
… Bim1-like Proteins (BLPs) and high-affinity copper transporters (CTR proteins) transcription levels. These two families of copper-binding proteins have been shown to facilitate copper uptake, which is critical for fungal growth, survival, and virulence, especially in the nutrient-restrictive …