Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 37 for “"cooperative interactions"”.
-
Biomolecular Condensates in Transcriptional Regulation
… regulates transcriptional activity. The highly cooperative interactions between components that positively and negatively regulate transcription have been mysterious for decades. However, recent study of biomolecular condensates has reframed our understanding of these cooperative interactions. …
-
The effect of ageing on the control of toe clearance during walking
… This thesis investigates the kinematic interactions of the lower limbs during unperturbed walking with a specific emphasis on examining the cooperative interactions of the stance and swing limb.
-
Computational Models of Function and Evolution of cis-Regulatory Sequences
… large scale TF-DNA binding data to identify cooperative interactions of TFs, to explore the effects of sequence organization on the TF interactions and to study the conservation of TF-binding affinities of sequences. The model we developed for predicting expression patterns of CRMs advances …
-
Total gene synthesis, bacterial expression and functional characterization of a recombinant human hemoglobin: Progress towards a blood substitute
… residues of hemoglobin in allosteric function, cooperative interactions, ligand discrimination and protein-protein recognition, a genetic handle is required. The use of total gene synthesis alleviates some of the laborious procedures associated with conventional cDNA cloning and circumvents the …
-
Re-visioning narrative competence: exploring kindergartners' collaborative story construction
… two or more children in complementary, i.e., cooperative, interactions (Howes, 1992; Roskos, 1988).
-
Additive effects among uterine paracrine factors in promoting bovine trophoblast cell proliferation
… objectives of this work were to establish if cooperative interactions between epidermal growth factor (EGF), fibroblast growth factor-2 (FGF2) and insulin-like growth factor-1 (IGF1) promote bovine trophoblast cell proliferation, and to decipher the intracellular signaling mechanisms employed …
-
Hierarchy of Interactions in Protein Evolution
… is complicated by the sheer number of possible cooperative interactions amongst the parts that make up biological systems. For even small systems such as individual protein domains, it has been difficult to comprehensively obtain high quality empirical data of amino acid interactions to …
-
Investigation of the dynamics and conformational changes of the U1A protein
… RNA complex is a model system for studying interactions between RNA and the RNA recognition motif (RRM), which is one of the most common RNA binding domains. Despite extensive studies conducted to study the origins of U1A-RNA affinity and specificity, little is known about the kinetics and …
-
Coordination of cellular force-generation during Drosophila ventral furrow formation
… with more neighboring contractions as well as cooperative interactions between neighbors. In Chapter 3, I examined how contractility is buffered against heterogeneity in cell apical area. I found that Cta-signaling is required to robustly maintain apical Factin cortex that can support …
-
Effects of checklist interface on nonverbal cockpit communications
… and configuration of the interface will affect interactions between the individual operators and the machine, and subsequently, the interaction between operators. In view of the latest trends in cockpit interface design and flight-deck technology--in particular, the centralization of displays …
-
Quantification of molecular aggregation equilibria using spectroscopic measurements and random mixing modeling
… the sign and magnitude of hydrophobic and ionic interactions remains a subject of theoretical debate, and has yet to be experimentally determined. Here, Raman vibrational spectroscopy is combined with multivariate curve resolution (Raman-MCR) to experimentally quantify both the number of …
-
Mechanistic investigation of coordinated conformational changes in multisubunit ion channels and enzymes
… conformational changes through allosteric interactions between subunits and/or between functional units can efficiently regulate protein activity. This dissertation describes investigations of coordinated conformational changes in two systems: the ATP-sensitive potassium (KATP) channel and …
-
Understanding perspective taking and its role in relation to teamworking and diversity
… social process guiding productive and cooperative interactions within and between work teams. I define perspective taking as the effortful and effective understanding of diverse cognitions, emotions, and identities tied to particular targets in particular situations. Little attention …
-
Analysis of Structure-Function Relationships in *Lambda and HK022 Site -Specific Recombination
… negatively charged residue was required for both cooperative Int-Xis and Int-Int binding, suggesting that E47 participates in two alternate types of cooperative binding contacts depending upon the binding context. Fourth, previously isolated Lambda Int mutants were characterized that resolved …
-
Statistical mechanical modeling of eukaryotic gene regulation
… on statistical mechanics to study the stochastic interactions of TFs and regulatory sequences. We present a predictive model to learn how TFs interact with cis-regulatory sequences and with each other. By analyzing large scale TF-DNA binding data, the model can discover cooperative interactions …
-
Decomposition of Proteins into Functionally and Evolutionarily Independent Cooperative Units
Understanding cooperative interactions within proteins is an important goal because cooperativity underlies protein functions such as catalysis, allostery, ligand binding and folding. Cooperative units within proteins can be revealed via an evolution based method called statistical coupling …
-
WATER SCARCITY, CONFLICT AND NEGOTIATION: FOUR ESSAYS
… puzzle in our understanding of interstate water interactions, my dissertation tries to answer three main research questions: How are interstate water interactions characterized in conditions of increased water scarcity? Can a more complex understanding of scarcity better explain the presence of …
-
Fracture mechanics in the semigrand canonical ensemble
… are shown to result from both the activation of cooperative interactions in soft-tough bulk phases and interfaces, and the transition from critical to subcritical bond fracture percolation in textured materials. While counter-intuitive on first sight, this soft-tough paradigm can explain a number …
-
Membrane protein conformational dynamics and ligand-binding interactions in bacterial glycoconjugate biosynthesis
… initial results characterizing inter-protein cooperative interactions. The integrated approach to incorporate computational and experimental characterization methods has significantly contributed to the understanding of SmPGT structure-function relationships and opened up new directions of …
-
Dissecting Roles for the Macromolecular Machinery Involved in Neurotransmitter Release
… functions that incorporates all of its known interactions and activating/inhibiting properties. I observed cooperative interactions between Complexin, the SNARE complex, and lipids by forming SNARE complexes anchored on nanodiscs and liposomes. Such cooperative binding of Complexin to …
Page 1 of 2