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Showing 1 to 11 of 11 for “"cooling crystallization"”.
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Optimal Control of Antisolvent and Cooling Crystallization
Common quality requirements for crystallization products is so critical in the pharmaceutical industry, including the demands of the drug administration and customers (e.g. bioavailability, size uniformity, and polymorphic form) and the concern of the manufacturer for downstream processes such as …
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Characterization of crystallization processes with video imaging
Crystallization processes are extensively utilized for the purification and separation of a variety of final and intermediate products. Despite its widespread use, in the fine chemicals, pharmaceutical and food industries, crystallization still has many unknowns which can affect the purity, quality …
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Formation of optimised particles for formulation and processing
… engineering techniques such as spherical crystallization or spherical agglomeration can be used in order to obtain spherical agglomerates with enhanced properties. Spherical agglomerates are produced through cooling crystallization in ethanol-water mixture under specific process conditions …
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Modeling, optimization, and sensitivity analysis of a continuous multi-segment crystallizer for production of active pharmaceutical ingredients
… flowrate, as well as the kinetic parameters of crystallization. We have lastly performed a parametric study on the use of the MSMA-PFC for in-situ dissolution of fine crystals back into solution. Fine crystals are a known processing difficulty in drug manufacture, thus motivating the development …
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Computational Fluid Dynamics and Population Balance Modeling of Particulate Systems
… aid in the design of process equipment for the crystallization of pharmaceutical compounds. The models focus on the combination of population balance equations and computational fluid dynamics software. For the simulation of antisolvent crystallization, knowledge of kinetics at high …
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Trace Element Geochemistry of Compositionally Layered Impact Spherules
… that have been interpreted to have formed by the cooling, crystallization, and quenching of melt droplets condensed from vapor plumes that are created during large meteor impacts. Spherules may be deposited globally as unique marker beds, such as at the K-Pg boundary. A minimum of 11 spherule beds …
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Gypsum seeding to prevent scale formation and improve separation efficiency
Eutectic freeze crystallization (EFC) is a novel separation technique that can be applied to treat brine solutions such as reverse osmosis retentates. These are often a mixture of different inorganic solutes. The treatment of calcium sulphate-rich brines using EFC often results in gypsum …
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Stochastic modeling of nonisothermal antisolvent crystallization processes
… a stochastic approach to model antisolvent crystallization processes is addressed. The motivations to choice a stochastic approach instead of a population balance modeling has been developed to find a simple and an alternative way to describe the evolution of the Crystal Size Distribution …
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Mathematical modeling and design of novel semi-continuous and continuous crystallizations
Crystallization is an important separation technology used for the purification of products during their final stages of manufacturing. Novel semi-continuous and continuous crystallization process designs are receiving increasing attention in pharmaceutical industry due to significant advantages in …
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Crystalization studies in hollow fiber devices
Crystallization was examined under a new perspective and in a flow environment much different from that available in currently used industrial devices. Three crystallization techniques were tested in the unique flow environment offered by hollow fiber devices. In addition, a new type of heat …