Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 34 for “"contusion"”.
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Contusion Progression in Traumatic Brain Injury
Cerebral contusions that result from brain trauma have the propensity to enlarge over the days following injury, including extension of the haemorrhage core and swelling of the surrounding peri-contusional brain. This secondary injury increases the likelihood of death and severe disabil- ity, and …
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The Molecular and Cellular Response to Pulmonary Contusion
… to 75% of all trauma-related deaths. Pulmonary contusion is a common and potentially lethal manifestation of blunt chest trauma, affecting 10-17% of all trauma admissions with estimates of mortality between 10-25%. The mechanisms responsible for both the local and systemic inflammatory processes …
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Development of a Finite Element Based Injury Metric for Pulmonary Contusion
… frequency of injury following MVC, and pulmonary contusion (PC) is the most common intra-thoracic soft tissue injury sustained as a result of blunt chest trauma. The goal of this dissertation research is to mitigate this commonly-sustained and potentially life threatening injury. We have taken a …
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Histological and Functional Characterization of Cervical Spinal Cord Injury After Graded Contusion
<p>Most spinal cord injuries (SCIs) are cervical contusions and result in deficits for both locomotion and reaching and grasping functions. Previous studies have characterized histological and functional deficits in locomotion using primarily thoracic contusions, but most patients have cervical …
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The Development of Pulmonary Contusion Finite Element Model Metrics from Real World Simulations
… cause of blunt chest trauma, and pulmonary contusion (PC) is a common injury following this type of insult. Over 38% of the Abbreviated Injury Scale (AIS) 3+ thoracic injuries were identified as some form of PC in a recent National Automotive Sampling System (NASS) study. In 2009, 33,808 …
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The role of substance P in cerebral edema associated with rat and human infarction and contusion
… rat models and human post mortem infarct and contusion tissue, demonstrated that in all the examined tissue, perivascular SP-IR was present in astrocytic processes rather than in nerve fibres. This implies that perivascular astrocytic processes might be more important than perivascular nerve …
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Humna fetal neural stem cells: Proliferation and differentiation in response to growth factors and role in locomotor recovery after spinal cord contusion injury
… in vitro and the outcome of hNSC grafting into contusion injured rat spinal cords in vivo.\r\nCells were cultured in seven regimens with basic fibroblast growth factor (bFGF), epidermal growth factor (EGF) and leukemia inhibitory factor (LIF), either alone or in combinations. We found that a …
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Pathological and Biomedical Characteristics of Spinal Cord Injury Determined Using Diffusion Tensor Imaging
… social impact. Scientists have long used animal contusion models to study the pathophysiology of SCI in the discovery of progressive secondary tissue degeneration, demyelination, and apoptosis. More importantly, most therapies that have gone to human clinical trial were first validated in spinal …
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Characterising changes in pathology and function in clinically relevant models of spinal cord injury and using chondroitinase ABC gene therapy to promote repair
… of optimised ChABC in a clinically relevant contusion injury model.<br/><br/>The first series of experiments involved a detailed characterisation of the temporal pattern of functional and anatomical changes that occur following a moderate thoracic contusion injury. Changes in dorsal column …
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Retinoic acid signaling after nerve injury
… with sciatic nerve lesions and spinal cord contusions have demonstrated that retinoic acid is involved in the physiological reactions after PNS and CNS injuries. The aim of this thesis was to identify the cellular targets of injury-related RA signals in the peripheral and central nervous …
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The role of ionotropic glutamate receptors in chronic central pain after spinal cord injury
… site (in area of sensory preservation). \r\n A contusion model of SCI was first characterized behaviorally and electrophysiologically. A contusion at spinal segment T10 at 150 kdynes of force and a 1 second dwell time resulted in the pain like behavior in the hindlimbs, thoracic region, and …
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Injectable hydrogels for the improved delivery of treatments in spinal cord injury
… for local delivery of biomacromolecules to SCI contusion lesions. To develop this hydrogel platform we synthesized a library of different tri-thiol-functionalized ethoxylated polyol esters (TEPE) and combined these entities with PEG diacrylates (PEGDA) of various molecular weights to form …
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Automated multi-well neural injury device
… TBI and the most prominent ones are concussion, contusion, hematoma, coup-contrecoup injury and diffuse axonal injury (DAI). The most severe type and the one that is the hardest to diagnose is DAI. DAI occurs mostly due to accidents relating to automobile, motorcycles and in some cases fall and …
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Investigation of chemokine expression and modulation following traumatic brain injury
… to be integral to the enlargement of cerebral contusions which accompany clinical deterioration following severe TBI. Previous studies indicated that the main neutrophil chemokine, macrophage inflammatory protein-2 (MIP-2/CXCL2) and the monocytic chemokine, monocyte chemoattractant protein-1 …
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Investigation into the Ehlers-Danlos syndrome
… described it as "Cutis Laxa with Tumours 'par contusion chronique des coudes et des genoux'". The same case was investigated in the same year by Pautrier who was the first to describe the histology of the condition.
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Influence of Peripheral Immune-Derived EphA4 on Microglial Dynamics Following Traumatic Brain Injury
… bone marrow GFP chimeric mice and the cortical contusion injury TBI model.
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Thalidomid und Rolipram führen zu funktionell relevanten Verbesserungen der Motorik nach traumatischen Rückenmarksverletzungen bei der Ratte
… assessed in an experimental model of moderate contusion-type, SCI in adult rats. A single intraperitoneal administration of both drugs administered immediately after injury, resulted in a statistically significant improvement in white matter sparing at the lesion epicentre. Furthermore the …
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Enzyme Analysis of Oxidatively Modified Proteins Post-TBI
… to a craniotomy and a moderate TBI via cortical contusion. Post-TBI rats in the saline group received an administration of saline (150mg/kg), and rats in the GCEE treatment group received an administration of GCEE (same dosage). Upon sacrifice, brains were harvested and enzymatic activity was …
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Violence against women : an analysis of the epidemiology and patterns of injury in rape homicide in Cape Town and in rape in Johannesburg
… be classified as minor or moderate and comprise contusion, abrasions and lacerations. 5. The incidence of rape homicide in Town is 7.2 per 100 000 women, which represents a fatal sexual rate 1.23%. 6. The majority of rape homicide victims were coloured women in the group 26 to 45 years. 6. Of …
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A COMBINATION THERAPY OF NICOTINAMIDE AND PROGESTERONE FOR FUNCTIONAL RECOVERY FOLLOWING TRAUMATIC BRAIN INJURY
… both NAM and Prog. Animals received a cortical contusion injury over the sensorimotor cortex and were treated with either nicotinamide (75 mg/kg, i.p. NAM loading dose, 12 mg/kg/hr NAM, s.c. over 72 hrs), Prog (10 mg/kg Prog, i.p. over 72 hrs), NAM and Prog(75 mg/kg, i.p. NAM loading dose, …
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