Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 20 for “"controlled-release drug delivery"”.
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A resorbable polymeric microreservoir device for controlled release drug delivery
The method by which a drug is delivered can have a significant effect on the drug's therapeutic efficacy. Pulsatile delivery of certain drugs and molecules (such as hormones) has been shown to more efficacious than continuous delivery, as the fluctuation in concentration levels in vivo more closely …
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Modeling of controlled-release drug delivery from autocatalytically degrading polymer microspheres
… of PLGA degradation and erosion and diffusive drug release with autocatalytic effects and nonconstant effective diffusivity of the drug. A mechanistic reaction-diffusion model with pore evolution coupled to hydrolysis and related to the effective diffusivity through hindered diffusion theory is …
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Design, development and optimisation of veterinary intravaginal controlled release drug delivery systems
… Thesis begins by discussing the application of controlled drug delivery to the intravaginal delivery of hormones to control the oestrous cycle of farmed animals, with particular emphasis on the delivery of progestagens to cattle and sheep. The introduction highlights the recent advances made by …
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Design of smart linkers and their applications in controlled-release drug delivery systems
Antibody drug conjugates (ADC) represents an interesting strategy in tumour targeted therapy . The approach is based on the combination of the high affinity of an antibody towards its antigen and the high cytotoxicity of a drug, leading to a selective therapuetic agent with improved efficacy and …
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Computational and Experimental Studies of Controlled Release Drug Delivery: Effect of Microsphere Diameter and Drug Size on in-Vitro Release Kinetics
… small-molecule, protein and oligonucleotide release have been clarified in this work.
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Lamination of a biodegradable polymeric microchip
… on the initial design of a polymer microchip for controlled-release drug delivery. Currently, the microchip employs a nonbiodegradable sealant layer, and the new design aims to fabricate it only of biodegradable parts. Experiments were conducted to evaluate two potential designs that are …
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Mechanical loading impacts intramuscular drug transport : impact on local drug delivery
Controlled-release drug-delivery systems enable efficient and defined administration of therapeutic agents to target tissues. However, ultimate drug distribution and pharmacologic effect are determined by target tissue pharmacokinetics. In muscular tissues, complex architecture that is further …
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Microcapsule drug delivery device for treatment of glioblastoma multiforme
Controlled-release drug delivery systems are capable of treating debilitating diseases, including cancer. Brain cancer, in particular glioblastoma multiforme (GBM), is an extremely invasive cancer with a dismal prognosis. The use of drugs capable of crossing the blood-brain barrier has shown modest …
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Design and in vitro development of resorbable urologic drug delivery device
Implantable, controlled release drug delivery devices offer several advantages over systemic oral administration routes and immediate drug release treatments including direct therapy to target organ, more continuous maintenance of plasma and tissue drug levels and the potential for reduced side …
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Surface Characterization of Poly (epsilon-caprolactone) at the Air/Water Interface
… systems have attracted considerable interest for controlled-release drug delivery and as scaffolds for tissue engineering, that require a fundamental understanding of PCL's degradation mechanisms and crystallization properties. PCL spherulites were commonly observed in previous bulk studies. This …
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Biopharmaceutic and Pharmacokinetic Evaluation of Hesperidin and Hesperetin for Ocular Delivery
… of hesperidin and hesperetin for ocular delivery, especially with respect to the distribution of these compounds to the posterior segment of the eye. Hesperidin and hesperetin were found to be water insoluble compounds. Although they demonstrated good permeability across the ocular …
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Theoretical prediction of drug release in GI tract from spherical matrix systems
The significance of controlled release drug delivery systems (CRDDS) lies in their ability to deliver the drug at a steady rate thus reducing the dosage interval and providing a prolonged pharmacodynamic effect. But despite the steadily increasing practical importance of these devices, little is …
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Oscillating Aqueous Gels as Drug Delivery Systems
… systems have been studied as potential novel controlled release drug delivery systems. They possess a unique oscillating property that was evaluated as a means of controlling drug release dependent upon intentional structural modifications of the systems.Based on the phase behavior of various …
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The effect of nanoclays on the properties of aspirin modified enteric polymer prepared by hot-melt mixing
… industry. This dissertation investigates two controlled-release drug delivery systems. The first system, namely the enteric matrix, contains an active pharmaceutical ingredient (API) and plasticizer in an enteric polymer while in the second system a nanoclay is added to the enteric matrix, to …
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Development and Optimisation of Nanoparticulate System for Brain Delivery of L-DOPA
… shortened life span. L-DOPA (LD) is the primary drug used for the treatment of PD. However, only 1% of the given dose is transported unchanged to the central nervous system (CNS) after oral administration due to its peripheral decarboxylation. As a result, LD has to be administered at high dose …
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DESIGNER COLLAGEN-FIBRIL BIOGRAFT MATERIALS FOR TUNABLE MOLECULAR DELIVERY
… physico-mechanical properties and controlled local therapeutic molecular release.
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Affinity-based Growth Factor Delivery from Injectable Hydrogels for Tissue Engineering
… strategies have been impaired by both poor delivery of therapeutic agents to the site of injury and a lack of sustained release that is required for long-term efficacy. In this thesis, a strategy for delivering protein therapeutics in a localized and sustained fashion is presented within the …
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Uniform double wall microspheres/microcapsules for protein delivery
… devices have been utilized as a means to deliver drugs in a controlled and less invasive manner. Poly (lactide-co-glycolide) (PLG) and poly (lactic acid) (PLA) microparticles such as double-wall/single-wall microspheres and microcapsules were heavily investigated for controlled delivery of small …
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Investigation of injection moulding for novel drug delivery systems. An investigation into the use of injection moulding to produce pharmaceutical dosage forms and to understand the relationship between materials, processing conditions and performance, in particular drug release and stability
… (IM) was explored for the development of novel drug delivery systems. Controlled release formulations were developed using a substituted cellulose derivative, hydroxypropyl methyl cellulose acetate succinate (HPMCAS) and a graft co-polymer (Soluplus®). BCS class II drugs ibuprofen and the …
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Evaluating the Structural and Functional Consequences of Traumatic Joint Injury and their Relation to NF-κB in a Non-Invasive Model of Post-traumatic Osteoarthritis
… pain-sensitivity related outcomes with repeated drug treatment were also observed. Nevertheless, local delivery of PHA-408 failed to modify long-term degenerative changes to articular cartilage. Engineered drug depots were also developed for the sustained release of PHA-408. While these …