Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 48 for “"controlled drug delivery"”.
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Development and Characterization of Controlled Drug Delivery Using Nanoparticles
The objective of this project was to develop new controlled drug delivery systems using nanomeric particles and characterize the delivery of drugs into cells in real time by digital fluorescence imaging microscopy techniques. The project is based on the idea that it could be possible to improve …
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EXPLOITING NANOSCALE MATERIALS PROPERTIES FOR CONTROLLED DRUG DELIVERY SYSTEMS
… objective of this work was to develop a novel drug delivery system exploiting special opportunities afforded by synthesis of nanoscale materials to be applied inside the colon. It must be robust enough to cope with the adverse conditions in the gastrointestinal tract (GI) and be able to reach …
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Developing Photo-responsive Metal-Organic Frameworks towards Controlled Drug Delivery
The development of therapeutic drugs or drug systems that enhance a cancer patient's quality of life during treatment is a primary goal for many researchers across a wide range of disciplines. Many investigators turn to nanoparticles (~50-200 nm in size) that tend to accumulate in tumor tissues in …
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Biosynthesis of Poly-3-Hydroxybutyrate and its Application in Controlled Drug Delivery
Controlled drug delivery has become a research focus in view of many of the drawbacks of conventional drug delivery including increased biodistribution and lack of target specificity, resulting side effects, and thus decreased patient compliance. Controlled delivery is the sustained administration …
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Electrospun scaffolds incorporating nanoparticles for controlled drug delivery in post-infarction cardiac repair
L'abstract è presente nell'allegato / the abstract is in the attachment
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Design of a novel electromechanical gastric resident device for long term controlled drug delivery
… of medication and deliver the medication in a controlled manner over long time periods (on the order of a month). Most gastric resident devices developed to date do not have the ability to load large doses of medication and release the pills in a controlled, pulsatile manner. Instead, they rely …
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A Novel Shear Thinning and Thixotropic Plga Micro Particulate Suspension System for Controlled Drug Delivery
… been the polymer of choice for many parenteral controlled drug release applications. This is mainly due to the inherent advantages of this polymer i.e. biodegradability, biocompatibility and non-toxic nature. The polymer, however, has a characteristic degradation pattern whereby the final …
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Theoretical prediction of drug release in GI tract from spherical matrix systems
The significance of controlled release drug delivery systems (CRDDS) lies in their ability to deliver the drug at a steady rate thus reducing the dosage interval and providing a prolonged pharmacodynamic effect. But despite the steadily increasing practical importance of these devices, little is …
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Polyurethane nanocomposites as potential drug delivery systems
… with remarkable potential in the field of controlled drug delivery. There are a range of factors proposed to perturb the release mechanisms in polymer NCs, but little focus has been directed towards the understanding of interactions between the drug and NC which can also affect the drug …
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TARGETING FIBROBLAST-MATRIX INTERACTIONS TO TREAT VOCAL FOLD SCARRING
… VF myofibroblast activation and to engineer controlled drug delivery systems targeting the cellular drivers of VF scarring. Our governing hypothesis is that matrix remodeling during fibrotic wound healing regulates VF scarring via fibroblast interactions and myofibroblast activation, which …
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PREPARATION AND CHARACTERIZATION OF AN ELECTROSPUN GELATIN/DENDRIMER HYBRID NANOFIBER DRESSING
… which provides a versatile and structurally controlled architecture to construct nanomedicine, was covalently bonded to the gelatin backbone and electrospun into nanofibers with gelatin, doxycycline and stabilizing polymers. The proposed gelatin/dendrimer hybrid provides a bacterial free …
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Endogenous and exogenous control of polymers for spatiotemporally defined drug delivery
Polymeric ‘smart drug delivery systems’ respond to external and environmental stimuli to modulate drug release at the right time and in the right place. Here I present several polymer systems to overcome challenges in spatiotemporal control of drug delivery. First, a novel acid-labile liquid …
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Synthesis and characterization of pH/temperature dual sensitive multiblock copolymer for drug delivery
… temperature and degradation at acidic pH for controlled drug delivery applications. The MBCP with molecular weight of 42000 Da was synthesized by polycondensation between an acid-labile ketal linker, 2,2-bis(aminoethoxy)propane (BAP) and Pluronic® P104 using L-lysine diisocyanate ethyl ester …
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Effects of cellular and tissue pharmacokinetics on control released growth factors
… Motivation: The resurgence of interest in controlled drug delivery reflects the increasing appreciation of the importance of local pharmacokinetics in defining the efficacy and potency of bioactive compounds. Despite promising data in vitro, growth factor use in vivo has generally failed to …
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Design and evaluation of drug loaded microbubbles for ultrasound guided cancer therapy
… (pDNA, siRNA) and chemotherapeutic (doxorubicin) drugs. We proved that these microbubbles can selectively deliver their genetic or chemotherapeutic drugs to melanoma cells upon ultrasound exposure. We also showed that the activity of currently available drug carriers (pDNA or siRNA lipoplexes and …
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Thermally-responsive interpenetrating polymer network nanoparticles as intelligent therapeutic systems
… serves as an ideal on/off trigger for controlled release of an encapsulated agent and could be used as a platform technology in a variety of applications. Solid gold nanoparticles (diameter ~ 40-50 nm) as well as gold nanoshells (diameter ~ 200 nm) were also synthesized using standard …
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Thermosensitive Injectable Pluronic Hydrogels for Controlled Drug Release: Characterisation of thermal, rheological and structural properties of injectable pharmaceutical formulations
… smart hydrogel formulations for injectable controlled drug delivery from Pluronics to enhance patients compliance, decrease side effects, reduce dose and frequency. A biocompatible copolymer, Pluronic F127 was probed as the main ingredient for the injectable systems owing its low gelation …
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Thermosensitive Injectable Pluronic Hydrogels for Controlled Drug Release: Characterisation of thermal, rheological and structural properties of injectable pharmaceutical formulations
… smart hydrogel formulations for injectable controlled drug delivery from Pluronics to enhance patients compliance, decrease side effects, reduce dose and frequency. A biocompatible copolymer, Pluronic F127 was probed as the main ingredient for the injectable systems owing its low gelation …
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Partikel und Kapseln auf Basis des rekombinanten Spinnenseidenproteins eADF4(C16)
… Freisetzung von Wirkstoffen oder Enzymen (controlled drug delivery) ist ein wichtiges Forschungsgebiet sowohl in der Pharmazie als auch in der Medizin. Mittels controlled drug delivery sollen Probleme der herkömmlichen Medikamentation behoben werden. Hierzu zählen beispielsweise …
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