Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 13 of 13 for “"controlled cortical impact"”.
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EFFECTS OF HYPERTONIC SALINE ON RECOVERY OF FUNCTION FOLLOWING CONTROLLED CORTICAL IMPACT BRAIN INJURY
… agents for the treatment of TBI. Following controlled cortical impact (CCI), bolus administrations of NAM (500 mg/kg), 7.5% HS, or 0.9% saline vehicle (1.0 mL/kg) were given at 2, 24, and 48 hrs post-CCI. Behavioral results revealed that animals treated with NAM and HS showed significant …
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Of mice and men: can MMP-9 be a biomarker and a potential target for treatment after traumatic brain injury?
… we have adopted an electromagnetic (EM) controlled cortical impact (CCI) mouse model along with refined surgical techniques and behavioral testing to mimic a precise, graded TBI. Here we compare our EM CCI mouse model of TBI to cerebrospinal fluid (CSF) from the severe human head trauma …
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The Role of STING-Mediated Neuroinflammation in Traumatic Brain Injury
… the role of the cGAS-STING pathway in a murine controlled cortical impact (CCI) model of TBI. Using cGAS knockout (KO) or STING KO mice, we show that global loss of either protein results in substantial neuroprotection. One day after injury, animals have reduced lesion size, cell death, and …
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Microglia-Mediated Neuroprotection from Concussion
Subconcussive impacts are highly prevalent in contact sports and are thought to increase concussion likelihood. However, we do not precisely understand the conditions under which subconcussive impacts affect concussion recovery, limiting both our mechanistic understanding and resultant recovery …
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Evaluating Microglia Dynamics in Blast and Impact-Induced Neurotrauma and Assessing the Role of Hemostatic Nanoparticles in Microglia Activation
… in military and Veteran populations, and impact-related trauma from contact-related sports or motor vehicle accidents has made mild impact-induced TBIs (concussion) a major health problem. There is a high risk for those who have sustained a TBI to develop behavioral and cognitive disorders …
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Translational Studies of Acute and Chronic Traumatic Brain Injury: Molecular Profiling of Tissue and Biofluids
… studies in two different rat TBI models (FPI and controlled cortical impact) showed that it was possible to measure distinct changes in peripheral (serum) miRNA profiles representative of each injury model, respectively. To gain greater insight into the mechanistic underpinnings of human TBI, …
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The Effect of Injury Severity on Behavioral Tasks Used for the Assessment of Cognitive Functioning Following Traumatic Brain Injury
… of the MWM. Following training, bilateral controlled cortical impact injuries were induced (mild bilateral frontal TBI, moderate-to-severe bilateral frontal TBI, or non-injured, sham). Following a seven day recovery period, rats were tested on the two assigned behavioral tasks. Following …
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Neuroprotective effects of gamma-glutamylcysteine ethyl ester on an in vivo moderate traumatic brain injury-mediated model and in vitro in cortical astrocytes and neurons
… neurons and astrocytes. For in vivo experiments, controlled cortical impact (CCI) was performed on Wistar rats to simulate moderate TBI, and GCEE (150 mg/kg) or saline was administrated 30 min or 60 min after the brain injury. Fluoro Jade-B (FJB), an ionic fluorescein derivate, was adapted to …
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Dynamic Measurement Of Soluble Human Aβ In A Combined Microdialysis-Experimental Traumatic Brain Injury Mouse Model
… at baseline and after sham-injury. Following controlled cortical impact TBI, we found that Aβlevels were immediately and persistently decreased in the ipsilateral hippocampus. These results were found in both wild-type mice and young pre-plaque PDAPP mice that produce human-sequence …
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An Assessment of Deficits in Simple Discrimination Following Frontal Traumatic Brain Injury in Rats: The Relative Contribution of Motor Deficits, Motivation Deficits and Neuroprotective Drug Administration
… to surgery and given either a bilateral frontal controlled cortical impact TBI or sham procedure. Following TBI, injured rats were given either doses of the neuroprotectant nicotinamide (NAM; 150 mg/kg, i.p.) or a saline solution (1 ml/kg, i.p.). They were then assessed for 35 days on the …
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Therapeutic Effects of Human Mesenchymal Stem Cells on Traumatic Brain Injury in Rats: Secretion of Neurotrophic Factors and Inhibition of Apoptosis
… an effective therapeutics for human TBI. The controlled cortical impact (CCI) model is frequently used for TBI models in animals because it enables the physical adjustment of injury levels and has close pathological resemblance to actual human TBI. However, little is known about the severity …
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The Association Between Traumatic Brain Injury and Alzheimer's Disease: Mouse Models and Potential Mechanisms
… of tau in this context. Here we report that controlled cortical impact TBI in 3xTg-AD mice resulted intra-axonal Aβ accumulations and increased phospho-tau immunoreactivity within hours and up to 7 days post TBI. Given these findings, we investigated the relationship between Aβ and tau …
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Preclinical Assessment of Immunocal® as a Preventative Treatment for Traumatic Brain Injury (TBI) in a Mouse Model of Closed Head Injury
… injury post TBI in a mouse model of closed head impact injury. We found that twice daily oral supplementation with 3.30% Immunocal® for 28-35 days prior to impact significantly improved animal motor coordination and to a lesser extent, cognitive performance. Histopathological results also …