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Showing 1 to 1 of 1 for “"controllable mutation"”.
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Development and road-testing of an inducible hypermutator strain of Pseudomonas aeruginosa
Hypermutation occurs when the mismatch repair (MMR) system becomes defective due to e.g., mutation. In Pseudomonas aeruginosa (PA), the mutS gene is commonly mutated in hypermutator strains. MutS mutants display an elevated mutation rate (>100-fold, compared with the wild-type (WT)) and are often …