Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 5 of 5 for “"control of the cell cycle"”.
-
Involvement of the WT1 and p16 genes in Wilms' tumour and human malignant mesothelioma
Normal cellular homeostasis is established and maintained by the positive and negative regulatory activities of many genes. When these genes are mutated to forms that can contribute to tumorigenesis, either by dominant, gain of function mutations in positive regulators or recessive, loss of …
-
High precision mass-based assay to examine growth regulation of the cell cycle
Studying biophysical properties of cells can provide insight into the metabolic mechanisms and regulation of cell cycle processes. Though size is considered to be a fundamental property of cell state, its measurement on a single-cell basis with high-resolution has been elusive primarily due to …
-
The function of E2F6 in the Polycomb complex
The E2F family of transcription factors are known cell cycle regulators that function at the G1/S transition. Unlike other E2Fs, E2F6 does not activate transcription and is not regulated by pocket protein binding. Instead, this protein appears to repress transcription through the recruitment of the …
-
Zelldifferenzierung und Apoptose bei kultivierten Zellen von soliden Mäusetumoren
With the heterogenity of subpopulations of two mouse tumors in mind, this thesis demonstrates the relations between the differentiation drift of these cells and apoptosis. In this connection it is important to keep in mind that cytokines have capacity to up-regulate neoplastic cells in …
-
Genomische Instabilität bei der humanen Ovarialtumorzellinie BG-1 durch hormonelle Proliferationsstimulierung
… BG-1 Zellen. Zusammengefaßt leitet sich die Hypothese ab: „Die Zellen werden auf Grund der hormonellen Proliferationsstimulierung durch den Zellzyklus „gejagt“, demzufolge werden wichtige „Checkpoints“ im Zellzyklus überlaufen, wodurch eine genetische Instabilität entstehen.kann“.