Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 24 for “"contrast-enhanced MRI"”.
-
Analysis of dynamic contrast enhanced MRI datasets
… is to perform automated analysis of 4D dynamic contrast enhanced MRI datasets (DCE-MRI) of the habd and wrist relating to rheumatoid arthritis (RA) studies. In DCE-MRI, sequences of images are acquired from the joints over time, during which a contrast agent pre-injected into a patient enhances …
-
Dynamic contrast-Enhanced MRI of Pancreatic Islet Transplants
… on intravascular injection of a FDA-approved contrast agent which leaks from and accumulates around permeable immature blood vessels. Rapidly acquired MRI scans following contrast administration can then show the location and extent of new vessel formations. Our studies showed dynamic …
-
Towards image registration of dynamic contrast enhanced MRI using deep learning
Dynamic contrast enhanced (DCE)-MRI is a quantitative imaging technique used to monitor microvascular perfusion. It involves rapidly acquiring multiple T1-weighted images over a few minutes whilst injecting a contrast agent, which causes a rapid increase in image intensity. Each type of tissue …
-
Dynamic Contrast-Enhanced MRI and Diffusion-Weighted MRI for the Diagnosis of Bladder Cancer
… aimed at evaluating the abilities of 3T dynamic contrast-enhanced MRI (DCE-MRI) and diffusion-weighted MRI (DWI) to improve the detection and staging and to enable the prediction of chemotherapeutic response in bladder cancer. A total of fifty-three patients were enrolled in the study. Different …
-
Alignment of contrast enhanced medical images
… of medical images in which there are multiple contrast variations is difficult. The reason for this is that the popularmeasures of image similarity used to drive the alignment procedure do not separate the influence of intensity variation due to image feature motion and intensity variation due …
-
Advances in targeted chemotherapy using MRI-guided focused ultrasound to disrupt the blood-brain barrier
… of the brain and magnetic resonance imaging (MRI) to guide and monitor the procedure. The purpose of this thesis was to develop a technique using MRI-guided focused ultrasound for trans bbb drug delivery applications. This thesis demonstrates that MRI-guided focused ultrasound can be used to …
-
Combination therapy studies with the vascular disruptive agent combretastatin-a4-phosphate (CA4P)
… heterogeneity of blood flow related dynamic contrast enhanced MRI (DCE-MRI) parameters between different patients and in lesions within patients on the A5B7 study. Increases in CO (mean +14%, p=0.026) occurred after CA4P whilst falls in tumour Ktrans values were seen (mean -25.1%; p=0.011). …
-
Functional Imaging to enable more accurate localisation and characterisation of prostate tumours
… patient management. Recently, multiparametric MRI has revolutionised the work-up of prostate cancer, becoming a routine part of clinical practice and migrating earlier in the diagnostic pathway. However, the technique remains challenging, with patient-related factors, intrinsic insensitivity of …
-
Effect of Acute Administration of Angiopoietin-1 In Experimental Traumatic Spinal Cord Injury: Magnetic Resonance Imaging and Neurobehavioral Studies
… Using longitudinal magnetic resonance imaging (MRI) studies (dynamic contrast-enhanced [DCE]-MRI for quantification of BSCB permeability, highresolution anatomical MRI for calculation of lesion size, and diffusion tensor imaging for assessment of axonal integrity), the acute, subacute, and …
-
Blood-Brain Barrier Permeability and Inflammation in Cerebral Small Vessel Disease
… system was used to acquire simultaneous dynamic contrast enhanced MRI with Patlak modelling to measure BBB leakage, and [C11]PK-11195 PET to assess microglia activation. We recruited 20 sporadic SVD patients, 20 monogenic SVD patients (CADASIL) and 20 healthy controls to this study. Results: BBB …
-
Venous Thrombosis: Formation, Evolution And Resolution Imaging Using Non-Invasive MRI Techniques
… the biological stage of thrombus organization. Contrast venography is still considered the gold standard for the diagnosis of DVT, even though thrombi are not clearly visualized and they are indirectly detected due to alterations in blood flow.The aim of this thesis was to develop and validate …
-
Vergleich zweier MRT-Kontrastmittel mit unterschiedlicher T1-Relaxivität zur Gefäßdarstellung bei Patienten mit abdominellen Aortenaneurysmen
… work is the comparison of different paramagnetic contrast agents in the examination of the infrarenal arterial vascular tree in magnetic resonance imaging (MRI) at 1.5 T in a group of patients with infrarenal aortic aneurysms. The two gadolinium-based contrast agents used are Gadopentat …
-
Three-dimensional Quantitative Magnetic Resonance Imaging of Carotid Atherosclerotic Plaque
… clinical events. High resolution, multi-contrast magnetic resonance imaging (MRI) can qualitatively identify these features and monitor disease progression. Compared to traditional contrast weighted imaging, quantitative MRI could provide an objective assessment of disease. Therefore, the …
-
Functional Magnetic Resonance Imaging of Breast Cancer
… examines the use of magnetic resonance imaging (MRI) techniques in the detection of breast cancer and the prediction of pathological complete response (pCR) to neoadjuvant chemotherapy (NACT). This thesis compares the diagnostic performance of diffusion-weighted imaging (DWI) models in the breast …
-
Assessment of myocardial viability using magnetic resonance imaging
… is still unclear. Magnetic resonance imaging (MRI) can be used to assess function, perfusion and viability using late gadolinium enhancement (LGE). Therefore, this thesis investigates how MRI can be used for diagnosis, prognosis and for understanding the pathophysiological mechanisms behind …
-
Mechanisms of vascular cognitive impairment in cerebral small vessel disease and stroke
… focusses on two longitudinal studies, the ‘PET-MRI-SVD’ and ‘Rates, risks and routes to reduce vascular dementia’ (R4VaD), which involved a CSVD (n = 77) and stroke (n = 201) cohort respectively. Multimodal neuroimaging data were acquired in both studies, including structural magnetic resonance …
-
Integrated Multimodal Analysis: Evaluating the Impacts of Chemotherapy and Electroporation-Based Therapy on Lymphatic and Blood Microvasculature in Cancer
… measured fluid flow fields from dynamic contrast enhanced MRI imaging building upon existing work, and showing the usefulness in comparing mechanisms of cancer cell invasion mediated fluid flow. Altogether, this work presents novel insight into the lymphatic system in cancer within …
-
DTI-ALPS REFLECTS WHITE MATTER DIFFUSION ANISOTROPY AND MICROSTRUCTURAL HETEROGENEITY RATHER THAN GLYMPHATIC FLOW: INSIGHTS FROM MULTI-MODAL MRI
… been widely adopted as a putative non- invasive MRI biomarker of glymphatic flow. However, the biological specificity of the DTI- ALPS index remains unclear, and recent evidence has raised concerns that it may primarily reflect white-matter (WM) microstructure rather than perivascular fluid …
-
Imaging Metabolic Signatures in High Grade Serous Ovarian Cancer
… but not with [<sup>18</sup>F]FDG PET. Dynamic Contrast Enhanced MRI measurements showed that the metabolic differences between the subtypes were not due to differences in tumour perfusion. I also investigated whether differences in tumour metabolism could help to predict and detect early …
Page 1 of 2