Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 246 for “"contractility"”.
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Actomyosin Contractility in Nonmuscle Cells
<p>Forces and stresses generated by the action of myosin minifilaments are analyzed via simulation of their motion in idealized computer-generated random, isotropic actin networks and actin bundles. The networks and bundles are generated as random collections of actin filaments in two dimensions …
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Mitochondrial Regulation of Arterial Contractility
… smooth muscle cells, thereby modulating arterial contractility.</p>
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Mechanisms of Actomyosin Contractility in Cells
… the ability of cells to exert contractile force. Contractility is used by cells to divide, to migrate, to heal wounds, and to pump the heart and move limbs. Contractility is mediated by the actin and myosin cytoskeleton, a dynamic and responsive meshwork that assembles into various well-defined …
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The effects of diethylstilbestrol on myometrial contractility in mice
… myometrium in mice and related them to uterine contractility (strength, duration, and rate) in Balb/c mice treated with 1.0 [micro]g DES or a placebo during a critical period of reproductive development from birth through two days old. At 30 days of age, uteri were removed and gross …
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CELL GEOMETRIC CONSTRAINTS REGULATE NUCLEAR AND CHROMATIN PLASTICITY VIA ACTOMYOSIN CONTRACTILITY
Extracellular mechanical signals (EMS) can regulate nuclear morphology and chromatin dynamics via the physical link from focal adhesions to chromatin via the cytoskeleton, linker proteins on the nuclear envelope and the nuclear lamina. However, how such force transmission from cytoskeleton to the …
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Actions of thyroid hormone on myocardial contractility in the intact animal
The central role of the mammalian heart in the circulation was recognised by Nei Chung when he wrote in his Third Book of the Yellow Emperor's Classic of Internal Medicine (2698 - 2598 B.C.): Treatise on the Five Viscera in Relation their part in Perfecting Life, "The Heart is in accord with the …
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INTERRELATIONSHIP BETWEEN CONTRACTILITY AND DYNAMICS OF ACTOMYOSIN SYSTEM IN NON-MUSCLE CELLS
… flow along the fibers) and myosin dependent contractility are related to each other in matured ventral stress fibers (VSFs) still remains elusive. To this end, I manipulated either actin incorporation or forces to investigate their effects. Surprisingly, SMIFH2 strongly inhibited the force …
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Effect of Long-term Hypoxia on Myometrial Contractility in the Pregnant Sheep
… from our laboratory has shown that myometrial contractility is reduced in pregnant sheep exposed to long-term hypoxia (LTH). The studies in this dissertation examined the effect of LTH on various aspects of Ca<sup>2</sup> regulation, large-conductance, Ca<sup>2+ </sup>activated (BK) channels …
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Differentiation and contractility of colon smooth muscle under normal and diabetic conditions
… chloride (KCl)-induced colon smooth muscle contractility. We hypothesized that decreased smooth muscle contractility at least in part, was due to alteration of contractile protein gene expression. However, diabetic mice showed no changes in mRNA or protein levels of smooth muscle contractile …
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Applications of Traction Force Microscopy in Measuring Adhesion Molecule Dependent Cell Contractility
This work describes the use of polyacrylamide hydrogels as controlled elastic modulus substrates for single cell traction force microscopy studies. The first section describes the use of EDC/NHS chemistry to convalently link microbeads to the hydrogel matrix for the purpose of performing long-term …
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The role of actomyosin contractility in zebrafish neural tube formation through hollowing.
… lumen formation. While the role of actomyosin contractility is well understood in primary neurulation, for example through constriction of apical-lateral junctions to mediate neural plate bending, its role in secondary neurulation is less clear. In this thesis, I investigated the role of …
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Transcriptional Regulation of Muscle Contractility and Metabolism by a MicroRNA-Mediated Feed Forward Loop
In response to physiological stimuli, skeletal muscle alters its myofiber composition to significantly affect muscle performance and metabolism. This process requires concerted regulation of myofiber specific isoforms of sarcomeric and calcium regulatory proteins that couple action potentials to …
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The Role of FGF Signaling in the Regulation of Adult Murine Cardiomyocyte Contractility and Pathologic Hypertrophy
… transgene led to immediate changes in cardiac contractility and the eventual development of hypertrophic cardiomyopathy (HCM) without progression to heart failure or premature death. Induction of caFGFR1 appears to increase the calcium sensitivity and decrease relaxation of the sarcomere …
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Effects of the MYH7 R369Q Dilated Cardiomyopathy-causing Mutation on Myosin Crossbridge Kinetics and Cardiomyocyte Contractility
… within a cardiomyocyte that results in hypocontractility. To better understand the biochemical and biophysical effects of R369Q mutation, this study utilized CRISPR/Cas9-edited R369Q homozygous human induced pluripotent stem cell-derived cardiomyocytes to investigate its effect on the myosin …
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The Distribution of Contractility Across The Wall of The Left Ventricle as Influenced by Coronary Hemodynamics
Made available in DSpace on 2014-12-11T22:22:13Z (GMT). No. of bitstreams: 1 7121254.pdf: 4261329 bytes, checksum: ebe10273c2feaeaf086fef47b994d794 (MD5) Previous issue date: 1971
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The Novel Role of Hematopoietic Lyn Substrate-1 Associated Protein X-1 in Cardiac Contractility and Cardioprotection
… the novel role of HAX-1 in calcium handling and contractility regulation. Over-expression of HAX-1 resulted in suppressed SR calcium re-uptake activity, reduced SR calcium content and depressed calcium kinetics, which were translated into reduced cardiomyocyte contractility. On the other hand, …
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Mechanisms underlying the development of weakness in idiopathic inflammatory myopathies: an in vitro single muscle fibre contractility study
… fibres were dissected out and subjected to contractility measurement based on standard protocols utilising a permeabilised single fibre system. Specific force (SF; maximum force normalised to cross-sectional area), was calculated for each fibre and compared between the two groups. In …
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