Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 14 of 14 for “"contractile performance"”.
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Contractile Performance and Energy Utilization of Skeletal Muscle; Creatine Kinase and Acto-myosin ATPase
… in cardiac muscle has found that PCr can alter contractile performance (maximal isometric force and Ca²⁺ sensitivity). Based on this evidence, CK and A‧M‧ATPase may be coupled in skeletal muscle. Therefore the purpose of this investigation was to determine the influence of the CK system on …
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The linking of angiogenesis to contractile performance and substrate metabolism in the hypertrophied and failing heart
… hearts into a state of failure marked by contractile dysfunction and alterations in the mechanisms governing energy production. The aims of this study were to investigate how alterations in ventricular capillarity affect contractile performance and substrate metabolism in the isolated rat …
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The influence of myosin regulatory light chain phosphorylation on the contractile performance of fatigued mammalian skeletal muscle
… in skMLCK knockout muscles attenuated contractile performance without a significant metabolic cost. Twitch force was potentiated to a greater extent in wildtype muscles until peak force had diminished to ~60% of baseline (37.2 ± 0.05% vs. 14.3 ± 0.02%). Despite no difference in peak …
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Force potentiation as a modulator of contractile performance: Implications for control of skeletal muscle force and energetics of work
… thesis investigated the modulation of dynamic contractile function and energetics of work by posttetanic potentiation (PTP). Mechanical experiments were conducted in vitro using software-controlled protocols to stimulate/determine contractile function during ramp shortening, and muscles were …
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The fiber type specific response of single muscle fiber contractile performance to endurance and resistance exercise training in healthy, sedentary adults
… analyzed for fiber type distribution and SMF contractile performance. In the EE group, MHC IIA/IIX expression decreased 12% (p<0.05) with no other changes in fiber type observed. Limited response in SMF contractile performance was observed in the EE group aside from a 11% decrease (p<0.05) in …
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Enhancing functionalities of engineered skeletal muscle tissues by recreating natural environmental cues
… skeletal muscle tissue is a three-dimensional contractile tissue made from muscle cells and the extracellular matrix (ECM). It can be used as a drug testing platform or an implantable tissue, but its practical use has been limited by inferior contractile performance and small size compared to …
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RalGDS-Dependent Cardiomyocyte Autophagy Is Necessary for Load-Induced Ventricular Hypertrophy
… littermates in terms of ventricular structure, contractile performance, and gene expression. However, Ralgds-/- hearts manifested a blunted growth response (p<0.05) to TAC-mediated pressure-overload stress as determined by heart weight to body weight ratios Ventricular chamber size and …
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The Role of STIM1 in Hypertrophy-Related Contractile Dysfunction
… and alterations in the molecular regulation of contractile performance. These adaptations can be regulated by various Ca2+-dependent signaling processes. STIM1 is an important regulator of Ca2+ signaling in different cell types by sensing endoplasmic reticular Ca2+ levels and coupling to plasma …
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Effects of mutant SHP2 expression on heart function in Duchenne muscular dystrophy
… used to determine the effects of mutant SHP2 on contractile performance and cardiac fibrosis. We found that 4-month-old DMD hearts with the SHP2 mutation have similar diastolic and systolic function compared to DMD hearts without the SHP2 mutation. However, there was a trend towards improved …
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Acute hypoxia-induced diaphragm dysfunction is prevented by antioxidant pre-treatment
… as indices of metabolism. Diaphragm muscle contractile performance was determined ex-vivo. Gene expression was examined at 1, 4, and 8 hrs using qRT-PCR. Protein/phosphoprotein content was assessed using a sandwich immunoassay. Proteasome activity was measured using a spectrophotometric …
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MIBG uptake in the hypertensive-diabetic rat heart
… and then to correlate these changes with the contractile state of the myocardium. By using the radioactive agent, I-123 meta-iodobenzylguanidine (MIBG), which has the same uptake, storage and release mechanism as norepinephrine (NE), a non-invasive measurement of the integrity of the …
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The Function Of Sarcoplasmic Reticulum In The Aged Rat Heart
… to the age-related alterations in myocardial contractile performance in Fischer 344 rats.;In cardiac membranes enriched in SR (MSR) and its light (LSR) and heavy (HSR) subfractions fractionated by a sucrose density gradient, the rate of ATP-supported and oxalate-facilitated …
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The Novel Role of Hematopoietic Lyn Substrate-1 Associated Protein X-1 in Cardiac Contractility and Cardioprotection
… for the examination of alterations in basal contractile performance and recovery after ischemia/reperfusion injury by HAX-1.</p><p> First of all, this dissertation reveals that HAX-1 is cardioprotective against ischemia/reperfusion. 2.5 fold over-expression of HAX-1 reduced infarct size and …