Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 22 for “"contractile dysfunction"”.
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The Role of STIM1 in Hypertrophy-Related Contractile Dysfunction
… and alterations in the molecular regulation of contractile performance. These adaptations can be regulated by various Ca2+-dependent signaling processes. STIM1 is an important regulator of Ca2+ signaling in different cell types by sensing endoplasmic reticular Ca2+ levels and coupling to plasma …
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Cellular mechanism of contractile dysfunction in diabetes-induced cardiomyopathy
… the cellular mechanism(s) that underlying contractile dysfunction in the streptozotocin-induced (type 1) diabetic cardiomyopathy compared to age-matched control heart. Human and animal studies have shown that diabetes mellitus can be associated with altered cardiac function that is …
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Cellular mechanism of contractile dysfunction in the diabetic heart
… the cellular mechanism(s) that underpins contractile dysfunction in the streptozotocin (STZ)-induced diabetic rat heart compared to age-matched control heart. In some experiments, a clinically relevant concentration of the volatile anaesthetic halothane (0.6 mM) was used examine its effect …
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Methods and adaptations required to perform small-animal MRI scanning using a large bore clinical MRI
… drop was observed at 4 weeks indicating contractile dysfunction. Wall thickness (WTh) analyses in MI rats at 4 weeks revealed significant reduction in end-diastolic (ED) wall thickness in the anterior region due to necrosis of myocytes. In the posterior region, WTh was significantly …
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Calciumkanaldichte in humanem ischämischen und reperfundierten, rechtsatrialen Myokardgewebe
… ultimately contributing to postischemic contractile dysfunction.
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K(ATP) channel Kir62 subunit distribution differs between muscles and between fiber types in skeletal muscle
… uptake, and the prevention of fiber damage and contractile dysfunction during fatigue. The extent of the cytoprotective capabilities of the KATP channel vary tremendously between muscles with different muscle fiber type composition. Semi-quantitative measurement of Kir6.2 subunit content showed …
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Investigation into the mechanism of Nox2 NADPH oxidase-dependent signalling in doxorubicin cardiotoxicity
… contributes to key processes underlying cardiac dysfunction associated with chronic DOX treatment. The aim of this study was therefore (1) to characterise the role of Nox2 NADPH oxidase-derived ROS in DOX-induced cardiotoxicity in a 4 week murine experimental model as the basis for detailed …
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Metabolic Regulation of Mtor Activation and Endoplasmic Reticulum Stress In The Heart
… endoplasmic reticulum (ER) stress and impaired contractile function. Both rapamycin and metformin restored glycolytic homeostasis, relieved ER stress and rescued contractile function. G6P and ER stress were also downregulated with mechanical unloading of failing human hearts. Taken together, the …
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Regulation Of The Tubulin Code In Cardiac Hypertrophy And Failure
… growth in cardiac hypertrophy and contributes to contractile dysfunction in heart failure. Yet how the heart achieves this modified network is poorly understood. Determining how the “tubulin code” – the permutations of tubulin isoforms and post-translational modifications – is rewritten upon …
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Effektivität von positiv inotropen Substanzen am Vorhofsmyokard von Patienten mit chronischem Vorhofflimmern
… And especially the transience of the atrial contractile dysfunction may play a pivotal role in a postfibrillatory positiv inotropic intervention. Hence we analysed the effect of some positive inotropic agents on the atrial myocardium of patients with chronic atrial fibrillation in vitro. …
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Modeling the Effects of Mechanical Loading on Hypertrophic Cardiomyopathy Pathogenesis in Human Induced Pluripotent Stem Cell derived Micro Heart Muscle
… in genetics have associated mutations in the contractile sarcomere apparatus of cardiomyocytes with hypertrophic cardiomyopathy, the most frequent cause of sudden cardiac death in the young. Currently, it is challenging to predict genotype-phenotype relationships in hypertrophic cardiomyopathy …
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The linking of angiogenesis to contractile performance and substrate metabolism in the hypertrophied and failing heart
… hearts into a state of failure marked by contractile dysfunction and alterations in the mechanisms governing energy production. The aims of this study were to investigate how alterations in ventricular capillarity affect contractile performance and substrate metabolism in the isolated rat …
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Atrial arrhythmogenesis in a murine model of mitochondrial insufficiency
… and unlike other murine models of mitochondrial dysfunction Pgc-1β-/- mice have a mild cardiac phenotype, devoid of confounding contractile dysfunction. All experiments were performed in young (12-16 weeks) and aged (>52 weeks) Pgc-1β-/- mice and compared to aged-matched wild type (WT) controls. …
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Characterizing the effects of in utero exposure to valproic acid on murine fetal heart development
… in gene expression has been associated with contractile dysfunction and myocardial disorganization. To characterize the effects of VPA on murine heart development, pregnant CD-1 mice were dosed with 400 mg/kg of VPA on gestational day (GD) 9 and ultrasounds were performed on GD 14 to 18, …
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Characteristics of cardiovascular dysfunction and pulminory hypertension in patients with sickle cell disease
… The<br/>contribution of cardiac and endothelial dysfunction to SCD also remains poorly<br/>understood.<br/>Aims<br/>(1) To characterise cardiac function in SCD patients using new 3-dimensional<br/>echocardiographic imaging techniques.<br/>(2) To determine the prevalence of PHT in SCD patients by …
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Bioenergetic and Metabolic Signatures of Maternal Overnutrition in the Offspring Heart
… obese dams exhibit hypertrophic remodelling and contractile dysfunction. Programmed alterations in mitochondrial respiratory function, substrate metabolism and oxidative stress have been implicated in offspring cardiac alterations, however these bioenergetic and metabolic phenotypes remain poorly …
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Erhöhte regionale Myokarddurchblutung und kontraktile Dysfunktion nach orthotoper Herztransplantation- Messungen mit fluoreszierenden Mikrosphären im Versuch am Hausschwein
Veränderungen der regionalen Myokarddurchblutung während einer Herztransplantation könnten somit eine wesentliche Ursache für das postoperative Graftversagen darstellen. Würde eine Beziehung zwischen der mechanischen Dysfunktion und einem verminderten myokardialen Blutfluß bestehen, wäre dies ein …
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Mechanisms and Functional Consequences of Cardiac Remodeling: Role of Myocardial Rac1 and Vascular Profilin1 Genes
… cardiac hypertrophy and associated cardiac dysfunction are either not or partially dependent on hemodynamic changes. Finally, hypertension is a major health problem and a main risk factor for cardiovascular diseases including left ventricular (LV) hypertrophy. Previously, we have shown that …
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Myocardial force and intracellular Ca2+ in an animal model of hypertensive heart failure
… has long been associated with diminished cardiac contractile function, yet the underlying cellular mechanisms are not well understood. The aim of this Thesis was to investigate the relationship between intracellular calcium ([Ca2+]i) and isometric force during the relatively narrow time frame in …
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Role of extracellular environment in mechanical properties of human cardiac fibroblasts and myofibroblasts
… of the myocardium, eventually leading to contractile dysfunction and chronic heart failure. Collectively, the formation of fibrotic scar tissue in the left ventricle inhibits its contractile function and leads to a cardiac output loss. Cardiac fibroblast and myofibroblast cells are …
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