Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 53 for “"continuous manufacturing"”.
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Computer modeling of a continuous manufacturing process
Thesis (S.M.)--Massachusetts Institute of Technology, Sloan School of Management; and, Thesis (S.M.)--Massachusetts Institute of Technology, Dept. of Chemical Engineering, 1998.
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The business case for continuous manufacturing of pharmaceuticals
Manufacturing in the pharmaceutical industry is presently characterized as a batch production system, which has existed in its current form for decades. This structure is the result of historical regulatory policy as well as the conservative nature of the industry. Recent clarification by US and …
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Melt extrusion and continuous manufacturing of pharmaceutical materials
… alternative processing technique that operates continuously, reduces the total number of unit operations, allows for incorporation of difficult-to-process drug substances, and has the potential to achieve tablets of better quality and consistency compared to traditional methods. Thus, our goal …
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Decoupling continuous manufacturing processes to increase new product valuation
… products. While the company’s highly automated, continuous manufacturing platforms efficiently produce large volumes of core business products, these systems lack the flexibility to quickly scale new products and respond to changes in customer demand. The goal of this thesis is to design a …
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Facilitating Adoption of Continuous Manufacturing Platforms in the Pharmaceutical Industry
Continuous manufacturing (CM) of pharmaceutical products has gained a great deal of interest over the past decade. CM promises multiple benefits to all pharmaceutical industry stakeholders; however, pharmaceutical manufacturers generally have been slow to invest in the technology and even slower to …
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Consolidation and Interweaving of Composite Members by a Continuous Manufacturing Process
… a working prototype of an automated process for manufacturing IsoTruss® and other innovative open lattice composite structures which yields faster, and more predictable and consistent parts, while automatically consolidating individual members. This machine is sufficiently versatile to …
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Materials properties of pharmaceutical formulations for thin-film-tablet continuous manufacturing
The development of manufacturing tablets in a continuous way has been possible greatly to the fabrication of polymer based thin-films. It is estimated that the pharmaceutical industry loses as much as a 25% on revenues based on the currently employed batch manufacturing method. Here we studied a …
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An equipment selection methodology for continuous manufacturing of small-molecule drugs
Flexible, modular, continuous manufacturing small-scale plants (MCSPs) for small-molecule drugs have been recognized as potential safe and economical solutions for pharmaceutical manufacturing. However, among the variety of equipment technologies required for an MCSP platform, there are only a few …
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Spray Freeze-Drying as a Solution to Continuous Manufacturing for Preserving Macromolecules
L'abstract è presente nell'allegato / the abstract is in the attachment
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Spray drying as part of the continuous manufacturing value proposition at Novartis
… is considering a complete overhaul of their manufacturing processes. To date, all drugs have been made by using a batch process. In an attempt to lower costs, Novartis is evaluating moving some drug production to a continuous process. Novartis has instituted lean in their production plants …
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Data-Driven Modeling and Real-Time Optimal Control of Continuous Manufacturing Processes
When faced with complex disturbances, continuous manufacturing processes require robust control and adaptability to maintain product quality and operational efficiency. Although advanced control strategies such as linear quadratic regulator, model predictive control, and adaptive control have …
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The development of a thin-film rollforming process for pharmaceutical continuous manufacturing
In this thesis, a continuous rollforming process for the folding of thin-films was proposed and studied as a key step in the continuous manufacturing of pharmaceutical tablets. HPMC and PEG based polymeric thin-films were considered for this application. An experimental apparatus was designed and …
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A Fault Classification System for Quality and Productivity Improvement in Continuous Manufacturing Processes
The manufacturing industry has recognized the need to improve the quality and productivity of its products and processes in order to increase its competitive position. In order to establish a high quality product companies install "quality systems" to improve product and process quality through …
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Design of a load-lock system for the lyophilization of unit-dose pharmaceuticals in a continuous manufacturing machine
… through batch processing, but implementing continuous manufacturing instead can lead to improved process control, higher quality product, and increased flexibility. Lyophilization involves four processing chambers at specific pressures and transferring vials between the chambers requires a …
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Development of fixed dose combinations using advanced engineering technologies
Traditionally manufacturing of drug formulations has been controlled by an established regulatory framework which ensured that final product quality was safeguarded. By carrying out testing of batch-based operations and comparison with raw material and end-product characteristics this quality is …
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Design of a rapid, continuous, small-scale device for creating dry powders from concentrated suspensions containing active pharmaceutical ingredients
… processes. The minimum time-to-patient for drug manufacturing is approximately 100 days. Using a continuous manufacturing process, the time-to-patient could be reduced to less than ten days. The scope of this paper encompasses the design of a machine for the desiccation of a mixture of solvent …
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Crystallization process development and spherical agglomerates for pharmaceutical processing applications
… costs of research and development, reductions in manufacturing costs by moving from batch to continuous manufacturing are necessary to sustain profitability of the pharmaceutical industry. Two different projects were researched to progress towards this goal. The first was the demonstration of a …
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Feature-based investment cost estimation based on modular design of a continuous pharmaceutical manufacturing system
Previous studies of continuous manufacturing processes have used equipment-factored cost estimation methods to predict savings in initial plant investment costs. In order to challenge and validate the existing methods of cost estimation, feature-based cost estimates were constructed based on a …
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Case studies in the modeling and control of continuous pharmaceutical manufacturing processes
… bi-specific antibodies, and viral vectors. The manufacturing of these products is as varied as the products themselves. Small molecules are synthesized chemically; i.e. by a series of key chemical transformation, work-up, and recovery steps. Larger molecules can be isolated from naturally …
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Mechanochemical preparation of multi-component pharmaceutical materials for enhanced physicochemical properties
… Consequently, this research aims to use a continuous manufacturing technique, hot-melt extrusion (HME), to manufacture multi-component systems while removing their intermediate handling.<br/><br/><i>Thesis embargoed until 31 December 2026</i>.
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