Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 6 of 6 for “"continuous manufacture"”.
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Design and development of polymeric nanoparticles by continuous manufacture using twin screw extrusion
… of dosage forms due to the ability to implement continuous manufacturing. <br/><br/>This thesis explores the use of extrusion as a tool to continuously manufacture polymeric nanoparticles without the use of solvents or water for the first time. Firstly, this work developed a strategy for the …
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Continuous manufacture of enabling formulations for a poorly soluble compound using hot melt extrusion technology
… the associated high costs arising from its non-continuous processing structure and inefficiency, the industry welcomes ideas which generate increased efficiency and cost-effectiveness. A concept which hot melt extrusion processing embodies.<br/><br/>The work presented in this thesis sought to …
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Development of cocrystals of water insoluble active substances with inactive excipients by using hot melt extrusion
… was used as a process analytical tool during the continuous manufacture of the cocrystals for further insight into the HME process. Scale-up of cocrystals was performed by increasing the throughput rate in the laboratory scale extruder without compromising the quality of the extrudates. Whilst …
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Thermoplastic-based pyrotechnic compositions
… systems may offer some advantages. This includes continuous manufacture via extrusion processes. Thermoplastic-based pyrotechnic compositions can be formulated by filling conventional polymer matrices with oxidants such as potassium nitrate. More interesting are fluoropolymer matrices as these …
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Continuous production of two archetypal metal-organic frameworks using conventional and microwave heating
… MOFs to investigate, with the aim of producing continuous synthesis routes for these MOFs. We selected two MOFs with well documented syntheses in the literature in order to allow us to quickly ascertain the relative performance of our materials and optimise these. We also explore the …
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Development and manufacture of novel amorphous Itraconazole drug products using quality by design principles
… novel approaches to product development using continuous manufacture with novel in-line process analytical technology (PAT) to monitor quality. The solubility parameter () of ITZ and polymers, Kollidon® VA64 (KOL), hydroxypropylmethylcellulose acetate succinate (HPMCAS) and polyvinylacetate …