Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 13 of 13 for “"continuous flow synthesis"”.
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Development of a continuous-flow synthesis of neostigmine methylsulfate and studies toward a continuous-flow synthesis of lisinopril
… Herein, we describe the development of a continuous flow synthesis of neostigmine methyl sulfate, an acetylcholinesterase inhibitor on the WHO list of essential medicines, and the transfer of the synthesis into a next-generation reconfigurable frame developed by our collaborators. Starting …
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Catalyst immobilization techniques for continuous flow synthesis
… in both research and industrial settings. As continuous flow processes continue to gain traction in research labs and fine and pharmaceutical chemical processes, new opportunities exist for implementing previously difficult catalytic transformations. The major goal of this thesis is to expand …
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Invention and implementation of technologies for continuous flow synthesis
In this thesis, I have optimized a synthesis of rufinamide an important epilepsy medication. This convergent synthesis generates two reactive intermediates in situ (aryl azide and propiolamide) and then combines them in a regioselective click reaction utilizing copper tubing as the catalyst. Next, …
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Enabling the use of unstable, hazardous reagents with continuous flow synthesis
… the pungent arylisocyanide starting materials, continuous flow chemistry is further demonstrated to provide safe and effective access to 2-arylindoles through in situ dehydration and cyclization of easy-to-handle 2-alkenyl-N-formylanilines. Laurel M. Heckman and Dr. Zhi He contributed equally to …
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Continuous flow synthesis of colloidal semiconductor nanocrystals: towards autonomous experimentation for accelerated material discovery
… the vast majority of work has focused on synthesis of semiconductor NCs containing toxic heavy-metal elements such as cadmium and lead. The inherent toxicity of heavy-metal-based colloidal NCs and the associated regulatory constraints have largely impeded their widespread implementation. …
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Synthesis and use of bench-stable precatalysts with heck-type activation and progress towards the continuous-flow synthesis of atorvastatin
… [color illustrations] Herein, we report the synthesis and characterization of a new class of air- and moisture-stable triphenylphosphine nickel(II) precatalysts, which activate through a Heck-type mechanism. The activity of these precatalysts is demonstrated with a carbonyl-ene coupling …
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Continuous processing of multiphase reactions for pharmaceutical applications
… and safety of pharmaceutical manufacturing, the continuous flow synthesis has appeared as an attractive alternative to the conventional batch processes. Numerous technologies have emerged to facilitate the development of continuous flow chemistry, and the benefits of flow chemistry have been …
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Photoredox activation of carbon dioxide and unactivated aliphatic carbonyl compounds
… Activation of Carbon Dioxide for Amino Acid Synthesis in Continuous Flow. Although carbon dioxide (CO₂ ) is highly abundant, its low reactivity has limited its use in chemical synthesis. In particular, methods for carbon-carbon bond formation generally rely on two-electron mechanisms for CO₂ …
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Continuous flow platforms for the synthesis of high-quality semiconductor nanocrystals
… these nanoparticles are produced via batch synthesis routes that suffer from various issues, including slow mixing, slow heating/cooling, and lack of batch-to-batch reproducibility. These issues escalate further when increasing the scale of the production, thereby hindering their application …
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Automated Execution and Optimization of Flow Chemistry on a Robotic Platform with Integrated Analytics
… characterization of chemical processes for the synthesis of organic compounds, which play a key role in society as medicines and materials, is currently an expensive and laborious enterprise. These inefficiencies are driving efforts to develop automated, data-rich experimentation (DRE) platforms …
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Developments and applications of methods for palladium- and copper-catalyzed carbon-nitrogen bond formation
… bond in the context of a biphasic continuous-flow system (Chapter 1). The second part of this thesis describes the recent developments of copper-hydride (CuH) catalyzed asymmetric hydroamination for the formation of a-chiral carbon(sp³)-nitrogen bonds from olefins. This work …
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Continuous synthesis of iron and aluminium-based nanoparticles
… and temperature. This thesis employs continuous flow processes as an alternative to standard batch processes to address the challenge raised by nanomaterial synthesis scale-up. Continuous processes are more reproducible because they provide accurate control over fluid dynamics, heat …
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Flow Chemistry Guided by Computer-Aided Synthesis Planning
… practitioners outside the core field of organic synthesis to fully leverage these advances, in part due to lack of experience in planning and executing synthetic sequences as well as often times incomplete communication of procedural information known only to expert practitioners. New tactics for …