Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 24 for “"contextual fear conditioning"”.
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Ontogeny of contextual fear conditioning: behavioral, neuropharmacological and molecular mechanisms
… changes in developing rodents using a variant of contextual fear conditioning called the context preexposure facilitation effect (CPFE). The CPFE is a variant of contextual fear conditioning in which acquisition of the contextual representation (preexposure phase) and association of the retrieved …
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NICOTINE MODULATION OF THYROID HORMONE SIGNALING AND ITS CONTRIBUTION TO COGNITION
… nicotine on hippocampus-dependent memory using a contextual fear conditioning paradigm. It was hypothesized that TRs would be critical for the acute effects of nicotine on contextual fear conditioning. Mice lacking the TRβ and TRα1 gene (KOs) and wildtype littermates (WTs) were administered acute …
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Strain-dependent and age-dependent effects of acute, chronic, and withdrawal from chronic nicotine on fear conditioning.
… from chronic nicotine administration on fear conditioning in 8 strains of inbred mice. Furthermore, nicotine withdrawal-related changes in somatic signs and the elevated plus maze were examined because nicotine withdrawal consists of multiple symptoms that can include increased somatic …
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Stress and Hippocampal Plasticity
… learning and memory process is dissected using a contextual fear conditioning paradigm in order to identify the component that can affect hippocampal cell proliferation. The results presented demonstrate that repeated stress, which activates the hypothalamic-pituitary-adrenal (HPA) axis and leads …
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Effects of LTD-blocking Tat-GluR2 Peptide on Contextual Fear Memory Impairments Induced by Cannabinoids
… mechanisms underlying cannabinoid impairment of fear memory is not clear. This study investigated the effects of the synthetic cannabinoid HU210 and the endocannabinoid hydrolysis inhibitor JZL 195 on fear memory following contextual fear conditioning (CFC; an animal model of fear). The long-term …
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Profiling hotspots of DNA breaks and learning-induced gene expression in the mouse brain
… function was unclear. In Chapter 2, following contextual fear conditioning (CFC) of wild type mice, we profiled the locations of DSBs genome-wide through gH2AX ChIP-Seq, along with transcriptomic changes in neuronal and glial-enriched nuclei in two brain regions. We found DSB-susceptible genes …
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Molecular mechanisms of memory formation : using activity regulated genes to identify active neural circuits
… induced in a sparse population of CA3 following contextual fear conditioning. Global knockout or selective deletion of Npas4 in CA3 both resulted in impaired contextual memory, and restoration of Npas4 in CA3 was sufficient to reverse the deficit in global knockout mice. Taking advantage of the …
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Impact of adult hippocampal neurogenesis on behavior
… hippocampal neurogenesis in behavior, especially contextual fear conditioning (CFC), is debated. Several studies demonstrated that blocking adult hippocampal neurogenesis in rodents impairs CFC, while several other studies failed to observe impairment. We sought to determine whether different CFC …
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A role for the SHANK1 scaffold protein in experience-induced synaptic plasticity and memory consolidation
… SHANK1-/- mice exhibit marked impairments in contextual fear-conditioning and radial-arm-maze retention. Similarly, mice that overexpress SHANK1 exhibit impairments in both cued and contextual fear conditioning, further suggesting that appropriate SHANK1 regulation is crucial for normal …
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Evaluating the regulation and function of adult mouse hippocampal neurogenesis induced from running
… to improved performance on water maze, contextual fear conditioning, and rotarod. Groups of running and non-running mice were either irradiated to reduce neurogenesis or not irradiated. Results showed that running enhanced performance over sedentary mice on contextual fear conditioning …
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Novel Roles for the Tissue Plasminogen Activator System in the Development of Fetal Alcohol Syndrome and the Regulation of Contextual Learning After Stress
… in tPA activity and PAI-1 resulted in decreased contextual fear conditioning in WT and PAI-1<sup>-/-</sup> mice. Chronic stress did not affect contextual learning in the tPA<sup>-/-</sup> mice. These results suggest tPA is necessary for the synaptic plasticity cascade that causes cognitive …
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Prenatal dexamethasone exposure: glucocrticoid programming of the brain
… cognition in the adult offspring, including contextual fear conditioning and behavioural flexibility on water maze tasks. I further explored possible molecular mechanisms that underlie the behavioural phenotypes of the prenatal dexamethasone rat model, and found altered brain gene expression …
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Pharmacological Intervention Reduces Hippocampal Hyperactivity in a Mouse Model of Psychosis
… (100mg/kg/day oral), as well as cued and contextual fear conditioning with haloperidol (1.75mg/kg/day oral). Haloperidol, but not levetiracetam, rescued the deficit in Social Recognition Memory. However, haloperidol did not alter the increased freezing in fear conditioning paradigm. …
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Investigation of the Role of Histone Acetylation in Hippocampus-Dependent Memory Formation
… inhibitors to enhance memory in the aversive contextual fear-conditioning task. In Chapter 4, I found that long-term memory for another hippocampus-dependent task, object location memory, is enhanced by the class I-selective HDAC inhibitor MS-275. This study provides a new behavioral paradigm …
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Cellular and molecular mechanisms underlying anesthetic-induced cytotoxicity, and their impact on learning and memory
… water maze, novel object recognition testing and contextual fear-conditioning. I discovered that sevoflurane exposure of the neonates compromised learning and memory in the adult animals in several subtle, albeit important ways. Some, but not all aspects of sevoflurane-induced learning and memory …
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Mapping the Cellular Landscape of the Brain: A Scalable Approach to Comprehensive Microscopy Data Analysis
… (ALNet) was designed to capture the long-range contextual dependencies inherent in 3D training data during supervised learning. Unsupervised learning leverages complementary features from the supervised approach, demonstrating the powerful synergy of this ensemble method. We applied MorPheT to …
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Evaluation of Sex Differences in the Hippocampus and Pituitary of Egr1 conditional knockout mice mediated by Nestin-Cre
… plus maze and lower freezing times during the contextual fear conditioning. RNA-seq had higher changes in females than males but was not affected by the Nestin-Cre system overall. The same RNA-seq changes in the pituitary gland were present, with females having higher genomic differentiation. …
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Age related memory loss and the role of the ubiquitin proteasome system
… and females, respectively. Further, using a contextual fear conditioning paradigm I found that learning increased proteasome activity and K48 polyubiquitin protein targeting in the hippocampus of aged male rats, contrasting with previous findings in young adult animals. My findings revealed …
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Identification and Characterization of Novel Mechanisms of Functional and Structural Synapse Remodeling: Focus on Vav Guanine Nucleotide Exchange Factors and MEF2 Transcription Factors
… Furthermore, Vav2/3-deficient mice have impaired contextual fear conditioning, as well as reduced anxiety. Together, findings support a role for Vav-dependent F-actin dynamics in BDNF-stimulated dendritic spine head enlargement and LTP, and normal hippocampal-dependent learning and memory and …
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The Medial Entorhinal Cortex's role in temporal and working memory : characterization of a mouse lacking synaptic transmission in Medial Entorhinal Cortex Layer III
… for acquisition, but not recall of tone and contextual fear memories in trace fear conditioning, and not in delay conditioning. This is the first demonstration that acquisition and recall of the same memory engram do not require the exact same anatomy. Additionally, this pathway is necessary …
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