Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 14 of 14 for “"contact site"”.
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Linking Architecture and Function of Endoplasmic Reticulum - Plasma Membrane Contact Sites
… cells form an intricate network of membrane contact sites (MCS) and thereby promote cellular functions such as lipid metabolism, signalling and organelle biogenesis. The formation of cortical endoplasmic reticulum (cER) - plasma membrane (PM) contacts in budding yeast cells is mediated by a …
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LOCALIZED WNT3A-SOURCES INSTRUCT MITOTIC ORIENTATION: DISSECTING THE WNT3A-TRANSDUCTION MECHANISM COUPLED WITH NUMA MACHINERY
… experiments conducted in HeLa cells dividing in contact with an in vitro niche system such as Wnt3a-coated nanospheres, revealed that canonical Wnt effectors including LRP6, β-catenin, DVL2 and Cav1 are implicated in the spindle axis alignment towards the Wnt3a source. In addition, we demonstrate …
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An obligate intracellular bacterial pathogen forms extensive and stable interkingdom contacts with the endoplasmic reticulum
… a rickettsial isolate, reminiscent of membrane contact sites (MCSs), where organelle membranes closely interact. MCSs play pivotal roles in maintaining cellular homeostasis and facilitating communication and trafficking within the cell. While vacuolar bacterial pathogens and viruses are known to …
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Structural and functional studies of intrinsically disordered fibronectin-binding proteins
… and, thus, might contain a preformed contact site involved in the initial interaction between SfbI-5 and 1−5F1. A high resolution structure of an SfbI-5 peptide in complex with 2F13F1 demonstrated that peptide binding occurs through formation of a tandem β-zipper with the concomitant …
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Identification and characterization of host genes involved in regulating replication of brome mosaic virus
… (Lipid transfer protein Anchored at a Membrane contact site 5) and that Lam5 is necessary for BMV replication in yeast. Furthermore, in the absence of Lam5, BMV 1a affects the distribution of lipid droplets throughout yeast cells. Host factors also play critical roles in defense against viruses. …
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Design criteria of a transcutaneous power delivery system for implantable devices.
… a sterile dressing on the skin cable-exit site. This contact site limits patient movement as it is vulnerable to wound infection due to trauma and poor healing. As a result, a sterile dressing has to be maintained and nursed regularly for treating the wound. Complications from the exit site …
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Involvement of Scribble protein in breast cancer invasion and metastasis
… in the phosphorylation pattern of four serine sites at the C-terminal of scribble, implicate scribble in breast cancer invasion and metastasis. This was due to CD74 overexpression in lymph node metastatic triple negative breast cancers. Investigating how changes in serine phosphorylation status …
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Interaction, integration, and innovation at the 17th century feira of Dambarare, northern Zimbabwe
… state and the Portuguese, and acted as points of contact between foreign and local traders. Dambarare, one of the more important feiras of the 17th century, was excavated in 1967 and the archive subsequently grew due to development activities in the region. In nearly fifty years, no-one has …
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A MULTIORGANELLE PLATFORM REGULATES EGFR ENDOCYTOSIS AND SIGNALLING
… via NCE by promoting the formation of contact sites between the ER and the plasma membrane (PM). These contact sites are essential for the formation and elongation of NCE intermediates known as tubular invaginations (TIs). Calcium, released from the ER at these sites through the …
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Opposing Actin Networks Modulate the Mechano-Activation of the Integrin LFA-1 During Immunological Synapse formation
… occurs at a regulated area of cell - cell contact termed the immunological synapse (IS). In T cells responding to APCs there is a robust accumulation of F-actin on the T cell side of the synapse. This F-actin response is characterized by robust polymerization at the periphery of the contact …
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Biochemical analysis of the interaction between transfer ribonucleic acid and exportin-t
… photocrosslinking was used to determine the contact sites between tRNA and exportin-t. 4-Thiouridine (s4U) was introduced into tRNAPheT.th by in vitro transcription with T7 RNA polymerase and crosslinked to exportin-t by irradiation at 312 nm. The crosslinking was Ran•GTP dependent and could …
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Multi-axial failure of high-performance fiber during transverse impact
… the immediate region around the projectile-yarn contact site for 0.30-cal round, 0.30-cal fragment simulation projectiles (FSP), and razor blades using high-speed imaging. Kevlar® KM2, Dyneema®SK76 and AuTx have been impacted at velocities ranging from ∼100 m/s to ∼1200 m/s depending on …
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Mitochondria-Endoplasmic Reticulum Contact Sites: Regulation and Roles in Coordinating Cell Fate Decisions
Mitochondria-endoplasmic reticulum (ER) contact sites (MERCs) form signalling platforms, which are required for cellular processes such as lipid metabolism, mitochondrial dynamics, mitochondrial Ca2+ signalling and apoptosis. MERCs are vital in coordinating cell fate decisions and their …
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Identifying novel roles for basement membrane-associated proteins in the adult Drosophila intestinal epithelium
… work revealed that mechanical regulation at the contact site between stem cells and their progeny is used to control cell number and enhances understanding of how mechanical signals contribute to intestinal epithelial homeostasis. In a separate project, I identified the conserved transmembrane …