Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 12 of 12 for “"contact guidance"”.
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Homeostatic mechanics for a synthetic cell: predictions on substrate anisotropies and cell-cell interactions
… timescales and cell motility ultimately lead to contact guidance for single adherent cells on fibronectin lines. We then proceed to analyse contact guidance of a different nature, contact guidance due to the heterogeneity of substrate elasticity, to uncover and analyse the different guidance …
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Homeostatic mechanics framework for modelling interactions of cells with the microenvironment
… In the first part of the thesis, we study the contact guidance of myofibroblasts on adhesive stripes of different widths. Contact guidance—the widely-known phenomenon of cell alignment induced by anisotropic environmental features—plays a crucial role in the micro-architecture of tissues and …
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Directed Cell Migration: From Single Cells to Collectively Moving Cell Groups
… of actin polymerization are involved in this guidance–known as contact guidance–as dynamic sensors of surface nanotopography. The dynamics of guided actin waves were measured to build and test predictive models of contact guidance. The distributions of actin-wave propagation speed …
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A MULTISCALE APPROACH TO STEM CELL-BASED CHONDROGENESIS FOR CARTILAGE REPAIR
… in the native tissue. In this study, we utilize contact guidance to develop constructs with microscale architecture for improved chondrogenesis and function. Stable channels of varying microscale dimensions were formed in collagen-based and polydimethylsiloxane membranes via a combination of …
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Investigation of electrospun fibrous scaffolds, locally delivered anti-inflammatory drugs, and neural stem cells for promoting nerve regeneration
… scaffold are considered. Structural support and contact guidance are crucial for promoting peripheral nerve regeneration. A method to fabricate peripheral nerve guide conduits with luminal, axially aligned, electrospun fibers is described and implemented in this study. The method includes the …
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Epithelial Cell Adhesion and Proliferation on Titanium(V) Biofunctionalized with Nanoceramic Thin Film
… wettability was evaluated via measuring water contact angle (n=5). Telomerase-immortalized human gingival keratinocytes (TIGKs) were cultured on each treated or untreated disk. Cell viability and adhesion were assessed at 6 and 24 hours via fluorescence microscopy (n=7), and proliferation was …
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Cell migration and alignment on mechanically controlled environment
This thesis studies the effect of mechanically controlled environment on cell migration and alignment in vitro. Understanding such behaviors are necessary to study wound healing of life, metastatic of cancer cells, tissue engineering, and regenerative medicines. First study is a cell migration …
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Effect of Electrospun Mesh Diameter, Mesh Alignment, and Mechanical Stretch on Bone Marrow Stromal Cells for Ligament Tissue Engineering
The overall goal of this research project is to develop methods for producing a tissue engineered ligament. The envisioned tissue engineering strategy involves three steps: seeding bone marrow stromal cells (BMSCs) onto electrospun scaffolds, processing them into cords that allow cell infiltration, …
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Novel biodegradable fibres for applications in tissue engineering and drug delivery
… yield a directional grooved pattern by drying in contact with a mandrel having a machined topography characterised by a peak-peak separation of 91 mm and a peak height of 30 mm. Differential scanning calorimetery (DSC) analysis of as-spun fibres revealed the characteristic melting point of PCL at …
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Complementary strategies to promote the regeneration of bone-ligament transitions using graded electrospun scaffolds
Grafts currently used for the repair of anterior cruciate ligament (ACL) ruptures integrate poorly with bone due to a significant mismatch in properties between graft and bone. Specifically, conventional grafts (e.g., hamstring tendon) are unable to recapitulate intricate gradients in …
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Patterning temporally dynamic 4D hydrogel and nanocomposite material gradients: predictive cellular and actuator responses
… order of cellular dimensions and that present contact guidance cue-rich environments for cells cultured on them in consequence (e.g. murine fibroblast, murine preosteoblast, or dorsal root ganglia cells isolated from rats). The high-performance micro-extrusion diameters that are accessible with …
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The Impact of substrate texture on cell behavior
Traditionally, cell studies have focused mainly on the effects of biochemical signals on cellular behaviour; however, there is a growing interest in investigating the effects of physical cues on the behaviour of the cells. Development of fabrication techniques has allowed researchers to design …