Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 8 of 8 for “"constraint-based modeling"”.
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Constraint-based modeling of host-microbe and microbe-microbe metabolic interactions in the human gut
… predictive, mechanistic computational models. Constraint-based metabolic modeling uses manually curated and validated metabolic reconstructions that constitute a genomically, genetically and biochemically structured knowledge base of a target organism. These reconstructions can be converted …
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Genome scale metabolic reconstruction and hypothesis testing in the methanogenic archaeon Methanosarcina acetivorans C2A
… This work highlights the great utility of constraint-based modeling for identifying feasible solutions to biological questions and provides insights into the workings of the cell at the genome scale.
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Methodology for architecture development for product design
… of the design structure matrix technique with constraint-based modeling to create a process that satisfies the following requirements: 1. Provide a means for modeling the system that provides the capability to gain feedback on proposed decisions. This promotes rapidly system learning. 2. …
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Metabolic network reconstruction and genome-scale model of butanol-producing strain clostridium beijerinckii ncimb 8052
… offer a sustainable alternative to petroleum-based production of butanol—an important chemical feedstock and potential fuel additive or replacement. C. beijerinckii is an attractive microorganism for strain design to improve butanol production because it (i) naturally produces the highest …
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A systems biology approach to understanding and improving butanol production in clostridium beijerinckii
… offer a sustainable alternative to petroleum-based production of butanol—an important chemical feedstock and potential fuel additive or replacement. Clostridium beijerinckii is an attractive microorganism for butanol production because it (1) naturally produces the highest recorded butanol …
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Identifying and modeling perturbed networks in cancer through statistical and constraint-based analysis
… Systems Biology. My work has focused largely on modeling biological networks—using both statistical and mechanistic modeling approaches—with applications to medicine, energy, and genomic science. The more coarse-grained of these approaches use statistical analysis of high-throughput expression …
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Systems biology of lung diseases: a multi-perspective view from host and pathogen
… knowledge base update, incorporating a ChIP-seq based transcription factor binding network containing 2556 interactions linking 104 transcription factors (TFs) to 647 metabolic genes, as well as an expanded metabolic model that can predict growth in a broad range of environmental conditions. My …
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Context-specific metabolic predictions
… The first study presents an optimization-based method to obtain context-specific metabolic predictions, and offers the advantage of being fully automated, i.e., free of user defined parameters. The second study explores the effects of alternative optimal solutions arising during the …