Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 4 of 4 for “"constitutive signaling"”.
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Constitutive activity in orphan G protein coupled receptors
<p>"The goal of this research was to use a distal signaling pathway analysis to evaluate the extent of agonist independent constitutive signaling among orphan class-A G protein coupled receptors (GPCRs). These receptors translate extracellular signals via conformational change into intracellular …
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Untersuchungen zum Aktivierungsmechanismus des Signalübermittlers gp130 und Bedeutung seiner juxtamembranären Region
… the IL-5 receptor TMD leads to a slight constitutive signaling, which is not seen in the chimera with the TMD of the gp130 chain. These results suggest that the gp130 TMD is stabilizing the inactive state of the receptor. It is demonstrated that the box1/2 region has to be located …
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The G protein-coupled receptor GPR30 signalosome - A novel G protein-independent mechanism regulating cAMP signaling and receptor trafficking
… The aim of this thesis was to elucidate the signaling and membrane trafficking of GPR30 in addition to look for any binding partners. My primary findings were: (1) GPR30 constitutively internalizes without any need for ligand binding. (2) GPR30 associates with cytokeratin filaments (3) GPR30 …