Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 3 of 3 for “"consensus design"”.
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Protein Engineering for Biomedicine and Beyond
… their target. Protein engineering enables the design of scaffolds that can bind targets of interest while increasing their stability, and expanding the scope of applications in which these scaffolds will be useful. Repeat proteins are instrumental in a wide variety of biological processes, …
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Das Gen-3-Protein filamentöser Phagen als Modellsystem zur Untersuchung von Proteinstabilität, Faltungsmechanismen und Prolylisomerisierung
… untersucht, inwieweit Proteine durch rationales consensus design von Beta-Turns stabilisiert werden können. Für N2 konnte durch Sequenzoptimierung von drei Beta-Turns die Stabilität tatsächlich praktisch verdoppelt werden, was die generelle Anwendbarkeit dieser Methode verdeutlicht. …
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Recombinant Proteins for Biomedical Applications
… described in chapters 2 and 3, and is focused on designed leucine-rich repeat proteins which offer increased stability, modularity, and surface area for binding interactions. These proteins bind at least two muramyl dipeptide ligands with picomolar to nanomolar affinity (Kd1 = 0.04 – 3.5 nM); as …