Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 30 for “"connexin43"”.
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Regulation of Connexin43 by Phosphorylation in Heart Development
<p>Serine/threonine protein kinases have been shown to reversibly regulate cell-cell communication through gap junctions formed by connexin 43 (Cx43) (Godwin et al.7 1993). The Cx43 protein expression levels are unclear and what role phosphorylation plays in the regulation of signal transduction …
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Enhancing spinal cord repair with connexin43 antisense oligodeoxynucleotides
… spread, swelling, inflammation, and scarring. Connexin43 (Cx43) gap junctions and hemichannels contribute significantly to spinal cord injury by remaining open in dying cells, spreading toxic substances to neighbouring cells and the surrounding extracellular environment, and exacerbating …
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Localized HB-EGF signaling and Connexin43 decrease in the myocardium
… the principal ventricular gap junction protein Connexin43 (Cx43) in cardiomyocytes. Thus, HB-EGF acts as an autocrine and local paracrine cardiac growth factor that leads to loss of gap junction proteins within a spatially confined microenvironment within the myocardium. This demonstration of …
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Vascular breakdown in diabetic retinopathy: Role of connexin43 and possible interventions
… are needed. Recent studies have shown that connexin43 hemichannels play a role in the pathogenesis of chronic inflammatory diseases and blocking these channels can alleviate vascular leak and inflammation associated with these conditions. However, there is conflicting literature with regards …
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Connexin43 as a novel therapeutic target in age-related macular degeneration
… stress, inflammation and vascular changes. Connexin43 (Cx43) is the most ubiquitous gap junction protein in mammals playing a role in intercellular communication. Increased Cx43 expression in the vasculature and astrocytes has been reported for many human central nervous system injuries. …
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Gatekeeper Connexin43 Phosphorylation Events Regulate Cardiac Gap Junction Coupling During Stress
Rapid and well-orchestrated action potential propagation through the myocardium is essential to each heartbeat. Gap junctions comprising primarily Cx43 reside within the intercalated discs connecting cardiomyocytes, effecting not only direct intercellular electrical coupling, but the localization …
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Mutations in Connexin43 and Connexin40 Associated with Human Atrial Fibrillation; Physiology and Mechanism
Atrial Fibrillation (AF), the most common sustained cardiac arrhythmia, is a disease that affects the electrical conductance in the atria. Gap junction channels, composed of connexin (Cx) proteins, allow the electrical signal to propagate between cardiac myocytes. Mutations in two highly expressed …
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Effects of a Serine 364 to Proline Mutation of the Connexin43 Protein in Transgenic Mice
<p>[Abstract Not Included]</p>
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Glial Changes and Role of Connexin43 in a Laser-induced Rodent Model of Retrobulbar Optic europathy
… nerve at different time points after the injury. Connexin43 Antisense Oligodeoxynucleotide has been investigated as a potential neuroprotective agent following the optic nerve injury. Results: Glial changes have been documented following laser-induced injury to the optic nerve. No optic nerve head …
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The Role of Connexin43 and Gap Junctional Intercellular Communication in the Apoptotic Process of Auditory Cells
Cis-diamminedichloroplatinum (cisplatin) is one of effective chemotherapeutic drugs for cancer therapy. Nevertheless, most patients treated with cisplatin are exposed to high risk of ototoxicity such as hearing loss or dizziness. It has been reported that ototoxicity occurs in about 75-100 % of …
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The Role of Gap Junctions in Congenital Diseases of the Heart
… of the heart and in embryonic development. Connexin43, the major protein of gap junctions in the heart, is targeted by several protein kinases that regulate myocardial cell-cell coupling. We hypothesized that mutations altering sites critical to this regulation would lead to functional or …
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Submembrane cytoskeleton-regulated assembly and functional activity of gap junctions
… beteiligt sind, identifiziert.Das Auftreten von Connexin43 (Cx43) in der Plasmamembran hängt von der funktionellen Aktivität der kleinen GTPasen Sar1 und ARF1 ab. Der Transport von Cx43 vom endoplasmatischen Retikulum zum Golgi-Apparat wurde durch die Expression einer GTP-restrikten Mutante des …
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Mechanically-induced intercellular remodeling of cardiomyocytes by magnetic micromanipulation
… for maintaining electrical impulse propagation. Connexin43 (Cx43) is the most abundant gap junction in the heart, and studies have shown that spatial heterogeneity of Cx43 may promote electrical instability and anisotropic conduction pathways that may cause cardiac arrhythmias. Structural and …
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Investigating viral subversion of intercellular communication
… communication. The gap junction protein connexin43 (Cx43; gene name – GJA1) is the most widely expressed human connexin protein and is the predominant connexin in the working myocardium. Given the immunological role for Cx43 gap junctions, we hypothesized that gap junctions would be …
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Contributions of type 2 IP3 receptors to intercellular adhesions and invasion of glioblastoma cells
… increases in mRNA for TGFBR2 and decreases for Connexin43 and CD63. I then assessed six candidates ZDHCC9, Connexin43, CD63, N-cadherin, Cadherin11 and TGFBR2 identified by the unbiased analyses in functional analyses of invasion and intercellular adhesion. Using siRNA against each of these …
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Cell penetrating peptide for ocular drug delivery
… neovascular AMD has been linked to uncontrolled Connexin43 (Cx43) hemichannel (HC) opening in the retina and the vasculature of the eye, leading to cell death, vascular permeability and vision loss. Cx43 HC block has proven to be effective in inhibiting the inflammatory cascade in various in …
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Alternative mechanisms of translation initiation in modulation of gap junctional coupling
… metabolic, and immunological coupling. Connexin43 (Cx43, gene name GJA1) is the most ubiquitously expressed gap junction protein, and Cx43 gap junctions are altered in pathological states including cardiac disease and cancer. The GJA1 mRNA undergoes alternative translation initiation to …
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Mechanisms of Intercellular Communication During Breast Cancer Progression Through Metastasis
… lost during EMT is gap junctions composed of connexin43 (Cx43), however, this is paired with an increase in expression of cytoplasmic Cx43 which binds microtubules. To elucidate the role of cytoplasmic Cx43 during EMT and breast cancer metastasis, we utilize a Cx43 mutant that has reduced …
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The Cx43 Carboxyl-Terminal Mimetic Peptide αCT1 Protects Endothelial Barrier Function in a ZO1 Binding-Competent Manner
… 1 (ZO1) , and the Gap Junction Protein (GJ) Connexin43 (Cx43). A ZO1-binding-incompetent variant of αCT1, αCT1-I, indicated that these effects on barrier function and barrier-associated proteins, were likely associated with Cx43 CT sequences retaining ability to interact with ZO1. These …
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Phosphorylation kinetics of cardiac gap junction regulation during stress
… Gap junctions consisting primarily of connexin43 (Cx43) connect cardiomyocytes at regions of contact between cells known as the intercalated disc to facilitate cellular coupling. Cardiac pathologies frequently manifest with disrupted gap junctional intercellular communication which can …
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