Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 42 for “"connectomics"”.
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Mechanistic Connectomics in Drosophila
Mechanistic Connectomics uses synaptic-resolution connectomes in a causal manner to explain circuit function. Multiple connectomes now exist for the adult fruit fly, \textit{Drosophila melanogaster}. This thesis develops statistics and analyses for Mechanistic Connectomics using these datasets to …
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Engineering Principles for Scalable Connectomics
… sectioning presents a significant challenge in connectomics, particularly when scaling to larger volumes. In the MICrONS 1 mm³ mouse visual cortex dataset, 25.1% of scanned images—representing over a month of imaging work—were discarded due to sectioning defects. Current methods result in …
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Tools for connectomics in C. elegans
Efforts to model computation in biological neural networks require knowledge of the structure of the network, the dynamics that play across it, and a network simple enough to be tractable to our incipient analyses. The simplicity of the 302-node nervous system of the nematode C. elegans and its …
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Deep Learning Tools for Next-Generation Connectomics
In recent years, the field of connectomics has witnessed exciting developments. Efficient algorithms are being developed to reconstruct nanoscale maps of large-scale images, allowing us a better understanding of how neural tissue computes. However, our ability to build powerful tools for the next …
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Enabling scalable multicolor connectomics through expansion microscopy
… a faster, cheaper, and multicolor approach to connectomics, and may have the potential to realistically tackle a nervous system as large and complex as a mammalian brain. Currently, the study and the development of Expansion Microscopy are limited by the rate at which experiments run, which can …
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Connectomics of extrasynaptic signalling: applications to the nervous system of Caenorhabditis elegans
Connectomics – the study of neural connectivity – is primarily concerned with the mapping and characterisation of wired synaptic links; however, it is well established that long-distance chemical signalling via extrasynaptic volume transmission is also critical to brain function. As these …
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U-Net Network Enhancements to Facilitate Rapid Electron Microscopy Imaging for Connectomics
… and lower cost electron microscopy imaging for connectomics.
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Mapping the Brain of the Clonal Raider Ant: Integrating Behavior, Neuroanatomy and Connectomics
<p>Ants have been studied extensively due to their advanced social structure and communication strategies. Olfaction plays a crucial role in their social behaviors, with ants using a variety of pheromones produced by different exocrine glands to communicate. For example, ants release alarm …
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Electrophysiological Markers of Sensory Plasticity and Connectomics in Ageing and Mild Cognitive Impairment
Measures of perceptual learning provide a unique window on one of the brain's defining characteristics: its ability to adapt to the demands of the external world. Such measures provide insight into disease-specific disruptions of neuroplasticity that have immense implications for biomarker and …
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Cross-classification clustering : multi-object tracking technique for 3-D instance segmentation in connectomics
… applied to achieve state-of- the-art accuracy in connectomics - the nanoscale mapping of neural tissue from electron microscopy volumes. This reconstruction system increases scalability by an order of magnitude over existing single-object tracking methods (such as flood-filling networks). This …
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Batch processing of brain tissue sections for millimeter-scale serial section transmission electron microscopy connectomics
The field of connectomics has emerged a promising approach for exploring the nature of neural circuits. A millimeter-scale connectome—a neuron-to-neuron wiring diagram of a neural circuit—potentially contains significant information regarding information processing and memory. The field is held …
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Inferential Methods to Find Differences in Population of Graphical Models with Applications to Functional Connectomics
In many neuroimaging modalities, scientists observe neural activity at distinct units of brain function but seek to study and manipulate functional connectivity or unobserved latent relationships between these units. Functional connectivity is commonly described using networks where nodes …
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Towards optical connectomics : feasibility of 3D reconstruction of neural morphology using expansion microscopy and in situ molecular barcoding
Reconstruction of the 3D morphology of neurons is an essential step towards the analysis and understanding of the structures and functions of neural circuits. Optical microscopy has been a key technology for mapping brain circuits throughout the history of neuroscience due to its low cost, wide …
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Omni : visualizing and editing large-scale volume segmentations of neuronal tissue
Connectomics researchers examine images of the brain in order to determine the structure of neuronal networks. As imaging techniques improve, images are growing in size and resolution - but they are also outgrowing the capacity of existing software to view these images. In response to this problem, …
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Elucidating the Principles of Brain Network Organisation through Neurosurgery
… to establish the clinical relevance of connectomics. This doctoral dissertation addresses this challenge by using diffuse gliomas as a model to study the principles of brain network organisation through neurosurgery. Specifically, I combined insight from a normative cohort of healthy …
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The Logic of Innately Aversive Olfactory Pathways
… an appropriate behavioural response. We used connectomics, functional imaging, and behavioural assays to determine the anatomy and function of this geosmin processing circuitry. Using behavioural assays, we show that the aversive response to geosmin is due to chemotaxis, and provide evidence …
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A system for scalable 3D visualization and editing of connectomic data
The new field of connectomics is using technological advances in microscopy and neural computation to form a detailed understanding of structure and connectivity of neurons. Using the vast amounts of imagery generated by light and electron microscopes, connectomic analysis segments the image data …
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Mapping the Spatial Transcriptome Across Whole Organisms
… integration of transcriptomic data with in situ connectomics and in vivo neural activity recordings. Understanding the spatial transcriptome in C. elegans is vital for insights into neural circuit coordination, disease mechanisms, and developmental biology.
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Online neuron reconstruction
… of the combined efforts of MIT's Computational Connectomics Group.
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Network approaches to understanding the functional effects of focal brain lesions
… this thesis is to investigate how the field of connectomics can contribute to understanding the effects of focal brain lesions and to functional brain mapping in neurosurgery. This datasets for this thesis include a clinical population with focal brain tumours and a cohort focused on healthy …
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