Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 10 of 10 for “"connective tissue growth factor"”.
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Connective Tissue Growth Factor in Pancreatitis
… and death. Chronic pancreatitis (CP) involves tissue destruction, exocrine and endocrine insufficiency, increased risk of pancreatic cancer and an extensive fibrotic pathology which is due to unrelenting collagen deposition by pancreatic stellate cells (PSC). Improved understanding of the …
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CONNECTIVE TISSUE GROWTH FACTOR IS REQUIRED FOR CHONDROGENESIS
Connective tissue growth factor (CTGF, CCN2) is expressed by mesenchymal cells during development. Mice genetically deficient in CCN2 display severe bone defects and die immediately after birth. The molecular basis of this defect is not known. We've used in vitro models of chondrogenesis to show …
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EFFECT OF ANGIOTENSIN PEPTIDES ON VASCULAR REMODELING
… were associated with a 32.8% decrease in connective tissue growth factor (CTGF), a 43.1% inhibition in phosphorylated Smad 2 and a 66.2% reduction in phosphorylated ERK1/2 in the arteriole wall of the cremaster muscle. Microvascular remodeling was independent of TGF-beta expression. The …
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Biomechanical regulation of arteriogenesis : defining critical endothelial-dependent events
… interactions. In particular, the transcription factor KLF2 was upregulated by the ACC waveform and several of its downstream targets displayed the expected modulation, including the downregulation of Connective tissue growth factor (CTGF). Moreover, delivery of endothelial conditioned medium …
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Drug delivery strategies to overcome ocular hypertension
… meshwork cells, where they effectively reduced connective tissue growth factor expression—a marker of fibrosis. These strategies provide enhanced drug delivery through prolonged release or co-delivery, offering promising alternatives for the management of chronic ocular hypertension.
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Investigating the role of PKC-β in tumour activated stromal cells
… malignant B-cells. PKC-β dependent cell contact factors have been shown to regulate drug resistance, but the role of soluble-factors for this protection remains unknown. Moreover, the role of PKC-β in stromal cells of other cancers remains largely uncharacterised. Here I demonstrate novel …
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Roles of CCN5 in regulating progression and therapeutic sensitivity of breast cancer
… nuclear hormone receptors and human epidermal growth factor receptor 2 (HER2), have worse survival rate compared to the patients with luminal subtypes of cancer. Here, we have shown that Cysteine-rich 61-Connective Tissue Growth Factor-nephroblastoma-overexpressed 5 (CCN5) induces growth arrest …
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Effects of Growth Hormone and Insulin-Like Growth Factor-I on Milk Protein Gene Expression and Nutrient Uptake and Cell Proliferation in Clonal Bovine Mammary Epithelial Cells
… was to further understand the mechanism by which growth hormone (GH) stimulates milk production in cattle. Three studies were conducted toward this objective. In the first study, the effects of GH and insulin-like growth factor-I (IGF-I), a major mediator of GH action in vivo, on cell …
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Regulation of endometrial repair and its impact on heavy menstrual bleeding
… menstrual bleeding (HMB). The mechanisms and factors involved in endometrial repair are still to be fully elucidated. Endometrial function is governed by the ovarian hormones and pre-menstrually progesterone levels decline as the corpus luteum regresses. Consequently, the synthesis of …
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Functional, Structural and Molecular Alterations in the Heart and Kidney During Diabetes Mellitus
… remodelling changes and underlying transforming growth factor β1 (TGFβ1) activity, gene expression profile of the ECM and calcium mediators using histological, immunohistochemical and quantitative gene expression analyses compared to age-matched Wistar control rats. Results: The results show that …