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Showing 1 to 20 of 606 for “"conjugation"”.
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Conjugation in abstract semigroups
… b = yx. In groups this coincides with the usual conjugation, but in semigroups, it is not transitive in general. Finding classes of semigroups in which primary conjugacy is transitive is an interesting open problem. Kudryavtseva proved that transitivity holds for completely regular semigroups, …
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Banach categories with conjugation.
Thesis (Ph. D.)--Massachusetts Institute of Technology, Dept. of Mathematics, 1969.
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Conformational Requirements for Cyclopropyl Conjugation
Made available in DSpace on 2014-12-09T17:35:47Z (GMT). No. of bitstreams: 1 6711918.pdf: 4302796 bytes, checksum: 4d0648833b39faa8a6c750b827999c48 (MD5) Previous issue date: 1967
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Peptide conjugation to enhance oligonucleotide delivery
… with a perfluoroarene. After oligonucleotide conjugation, these peptides led to a 14-fold increase in delivery. Second, two different CPPs were combined into one long chimeric sequence. The CPP chimeras were highly active, leading to a 20-fold increase in oligonucleotide delivery. Third, the …
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Conjugation of extrachromosomal replicons of Rhodococcus erythropolis AN12
… required to initiate DNA transfer during plasmid conjugation. Sequences adjacent to the transposon insertion in megaplasmid pREA400 revealed a putative traA-like open reading frame. A novel site-specific gene disruption method was developed to generate a traA mutation in AN12, which allowed us to …
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Chemical and biochemical studies of ubiquitin conjugation machinery
… cascade catalyzed by E1, E2, and E3 enzymes. Ub conjugation is important for fundamental cellular processes, including transcription, DNA repair, endocytosis, apoptosis, and signal transduction. Ub conjugation is reversible. Proteases termed deubiquitinating enzymes (DUBs) function to remove Ub …
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Focusing Light Inside Scattering Media with Optical Phase Conjugation
… deep inside scattering media, optical phase conjugation based wavefront shaping techniques, such as time-reversed ultrasonically encoded (TRUE) optical focusing, are being actively developed. In this dissertation, I will describe our efforts to improve the performance (speed, focusing quality …
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ISG15 conjugation : cellular targets and the lysine selectivity of HERC5
… proteins to block the anti-viral effect of ISG15 conjugation. HERC5 is the major ISG15 ligase in humans and targets hundreds of cellular and viral proteins for ISGylation. HERC5 associates with polysomes and appears to target nascent polypeptides in a near stochastic manner, with limited substrate …
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Characterization of two prevalent yet distinct conjugation systems among lactococci
… through natural gene transfer methods including conjugation can be a highly advantageous approach, though with its challenges as (plasmid) conjugation efficiencies between lactococcal strains reported in literature have been very low. This thesis describes the optimization and characterization of …
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Surface conjugation of upconversion nanoparticles via supramolecular host-guest self-assembly
Surface functionalization and conjugation hold the key to driving many purpose-synthesized nanoparticles into real-world applications. Lanthanide (Ln) ions doped upconversion nanoparticle (UCNP) is a good example: while it delivers a great promise as molecular probes, sensors, drug carriers and …
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Studies in Conjugation: Huffman Tree Construction, Nonlinear Recurrences, and Permutation Networks
Made available in DSpace on 2014-12-13T18:02:07Z (GMT). No. of bitstreams: 1 7913571.pdf: 6291041 bytes, checksum: 2dcb006e5f0759a6f113324457fb606d (MD5) Previous issue date: 1978
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DNA enzymes for peptide-nucleic acid conjugation and for lysine methylation
… approach for DNA-catalyzed peptide nucleic acid conjugation is described. This new selection approach uses untethered, free peptide substrates containing an azido group at the N-terminus. Capture of the catalytically active sequences by Cu(I)-catalyzed azide-alkyne cycloaddition (CuAAC) with a …
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Genes controlling conjugation and mitotic cell division in yeast saccharomyces cerevisiae
Thesis (Ph. D.)--Massachusetts Institute of Technology, Dept. of Biology, 1988.
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A first approach to individual-based modeling of the bacterial conjugation dynamics
… explicit individual-based model of bacterial conjugation using use a discrete representation of time and space. The space is defined by a discrete grid where agents are place and evolve through their local interactions. Each agent is described by a state vector updated according the model …
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The conjugation and evaluation of hydrophobic small molecules to trazole-linked siRNAs
According to the Human Development Index, it is estimated that all cancer cases will rise from 12.7 million cases in 2008 to 22.2 million by 2030. Traditional therapies, including surgery, radiation therapy, and chemotherapy, have difficulty in specifically selecting malignant tissues for …
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Conjugation of Zwitterionic and Cationic Peptides to Lipid and Polymer for Gene Delivery
… materials that we established by the chemical conjugation between the peptides and the corresponding backbones. In total, we focus on 3 types of conjugates mainly. They are the zwitterionic peptide (EK)x pair lipid DSPE conjugates, THE DSPE-(EK)x, the cationic ionizable peptide RxHy lipid DSPE …
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Design of Human Serum Albumin and Adenovirus Conjugation via Catcher/Tag Molecular Glue
<p>Adenovirus (Ad) has been the ideal cargo delivery mechanism, and its moderate immunological response makes it ideal for in vivo gene therapies since its discovery in 1953. However, the robust immunogenicity of the Ad capsid and low vaccine absorption via mucous membranes and epithelium put a …
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