Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 449 for “"conjugates"”.
-
The Development of Methods for Generating Fc-Conjugates and Antibody-Drug Conjugates
… with therapeutic peptides to generate Fc-peptide conjugates. Many biologically active proteins and peptides suffer from an extremely short plasma half-life, which limits their therapeutic potential. A common half-life extension strategy employs the fusion of a biotherapeutic to the Fc fragment of …
-
Stealth Polymer Conjugates of Biologics
… colloquially termed PEGylation. PEGylated drug conjugates have a much longer plasma half-life than the native drug due to their larger size leading to slower renal clearance, reduced opsonization that reduces clearance by the reticuloendothelial system (RES) organs, and improved solubility. …
-
Synthesis of staphyloferrin B (SB)-cargo conjugates
… infections involves the use of siderophore-drug conjugates to selectively deliver antibiotics to bacteria. Siderophores are low-molecular-weight chelators with high affinity for iron(Ill) that are biosynthesized by bacteria to acquire iron from the environment. Several reports of …
-
Synthesis of peptide-ligand conjugates and their applications
… (i) synthesis strategies of peptide-ligand conjugates, (ii) their applications and (iii) chemistry of ferryls were surveyed in the introduction chapter. Next, the divergent and dual divergent strategies for the synthesis of non-heme ligand-peptide conjugates were developed. Using these …
-
Synthesis and Characterisation of Photoresponsive Azobenzene-Biomolecule Conjugates
… of carbohydrate, peptide and nucleic acid conjugates. The preparation of range of monosaccaride, disaccharide and nucleoside azobenzene conjugates are detailed. The synthesis of a number of new azobenzenes bearing either 1,3-dipoles or their precursors, or dipolarophiles is described. …
-
Small molecule-degrader conjugates for MALAT1 triplex degradation
Metastasis is the primary cause of death associated with oncological disease. However, the biological processes of metastasis still need to be fully rationalised and understood. The insurgence of secondary neoplasms for numerous types of cancer has been correlated multiple times to the …
-
ANTIBODY-DRUG CONJUGATES FOR THE TREATMENT OF BREAST CANCER.
… emtansine (T-DM1) are anti-HER2 antibody-drug conjugates (ADCs) which have shown robust efficacy for treating breast cancer. For both ADCs, however, we lack effective biomarkers to predict outcomes from pre-treatment samples. Methods: To unveil predictive biomarkers for ADCs, we first evaluated …
-
SERS & efficacy assessment of anti-cancer drug-nanoparticle conjugates
… erlotinib to the free drug was assessed. EL-NP conjugates were characterised in solution and mapped in fixed cells by SERS at 300 nM EL. This was a high resolution time-lapsed intracellular localisation study. The alkyne signal from silver conjugates were found to occupy more of the cell volume …
-
Delivery and stability of antisense oligonucleotide conjugates in vitro
… and to assess the stability of two ODN conjugates, in vitro. The first conjugate aimed to improve uptake of ODNs via mannose receptor mediated delivery, the second investigated the improved delivery of ODN conjugates via non-specific lipophilic interaction with the cell membrane. A …
-
Protein Synthesis and Bioconjugation for Design of Antimicrobial Conjugates
New antimicrobial approaches are needed to combat the threat of antibiotic resistance. Gram- negative bacteria are of significant clinical concern, in part due to their cell wall structure that restricts the transport of most antibiotics. Here we describe the development of two chemical strategies …
-
Quantitative analysis of cellular processing of Antibody-Drug Conjugates
Antibody-Drug Conjugates (ADCs) are a promising therapeutic class which combines the potency of chemotherapeutic drugs with the specificity of a tumor targeting antibody. ADCs aim to reduce systemic toxicity and maintain or improve therapeutic efficacy. Once an ADC reaches a tumor and binds its …
-
Development of 64Cu/NOTA-terpyridine platinum conjugates as chemoradiotheranostic agents
Le cancer colorectal est l'un des cancers les plus répandus dans le monde et au Canada. Il présente une résistance intrinsèque et acquise aux agents chimiothérapeutiques à base de platine. Plusieurs mécanismes sont impliqués dans la résistance des tumeurs à ces agents, y compris une internalisation …
-
PNA-protein conjugates for nano-scale modeling of protein aggregates
… PNA via expressed protein ligation. The mTFP-PNA conjugates were efficiently aligned on a DNA beacon, to create a hetero-FRET system. The FRET indicated by decrease of fluorescence intensity and lifetime of the donor and an increase of donor anisotropy. The assembly of similar multiple mTFP-PNA …
-
Anthraquinone-peptide conjugates as inhibitors of DNA transcription factor binding.
… Biophysical analysis of the peptide conjugates with DNA using fluorimetry and thermal denaturation studies indicated that the AP-I inhibitors were weak intercalators of DNA and suggested that DNA binding of these intercalator-linked peptides was govemed~ in principle, by the peptidic …
-
The Development of a Tumour-Responsive Format for Antibody Conjugates
Antibody-drug conjugates (ADCs) are an emerging class of targeted therapeutics which exploit the selectivity of monoclonal antibodies towards particular membrane receptors, to deliver potent cytotoxins to a desired cell type. A significant amount of research has been undertaken to improve the …
-
Bioinspired functional DNA-nanomaterial conjugates for diagnostic and therapeutic applications
… probe by using fDNA-Janus nanoparticle conjugates is presented. Second, a general platform using fDNA and liposomes is developed for the multimodal detection of small molecules and targeted breast cancer chemotherapy. Third, a novel single chain polymer-based organic nanoparticle system …
Page 1 of 23