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Showing 1 to 20 of 72 for “"conjugate addition"”.
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Organocatalytic conjugate addition reactions
… to be an efficient catalyst for base catalyzed conjugate addition between 2(3H)-furanones and maleimides. Aromatic furanones substrates proved to be better than alkyl furanones, giving higher yields and better ees. The best result is a decent ee of 70%. There is still room for improvements in …
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The Conjugate Addition of Tert-Butylmagnesium Chloride to Ortho-Hydroxy Diaryl Ketones
Made available in DSpace on 2014-12-05T19:36:03Z (GMT). No. of bitstreams: 1 0010470.pdf: 2523004 bytes, checksum: ba3a5d7aeba1b41d6ed3d9dddec85cd1 (MD5) Previous issue date: 1954
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BINOL-Catalyzed Asymmetric Synthesis of Chiral Heterocycles; Experimental Mechanistic Study of Binol-Catalyzed Conjugate Addition of Vinylboronic Acids to Enones; Enantioselective Synthesis of Diarylalkane Compounds via Binol-Catalyzed Conjugate Addition
A BINOL-catalyzed conjugate addition was shown in our laboratory to be compatible with unprotected indole substrates. This was considered to be an advantage over typical organometallic strategies since it allowed the use of mild boron-based nucleophiles. With this well established method, we …
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The Conjugate Addition of Tert-Butylmagnesium Chloride to Cinnamaldehyde and (alpha,beta,beta)-Triphenylacrylophenone
Made available in DSpace on 2014-12-05T19:36:06Z (GMT). No. of bitstreams: 1 0010499.pdf: 2579209 bytes, checksum: 2516bb918e9ae0fefbae2cbb360eb855 (MD5) Previous issue date: 1954
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(-)-Sparteine Mediated Lithiation of N-Boc-N-P-(methoxyphenyl) Allylic Amines and Conjugate Addition to Nitroalkenes: Scope, Reaction Pathway, and Synthetic Applications
The enecarbamate products of the conjugate additions may also be easily elaborated to enantioenriched functionalized cyclopentanoids. Hydrolysis of the enecarbamates followed by intramolecular nitro-aldol cyclization and dehydration provides substituted nitrocyclopentenes that were converted to …
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(--)-Sparteine Mediated Asymmetric Synthesis Through Conjugate Addition of Allylic and Benzylic Organolithium Species: Development of a Methodology and Its Application Toward a Total Synthesis
… gamma-lactams in high yield. In addition, conjugate addition of the allylic organolithium species with N-protected 4-pyridones provides high yields of the corresponding 1,4-addition adduct with high enantiomeric ratios (ers). The reaction is believed to proceed through an N-acyl …
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Cascade Transformations in Organic Synthesis: I. The Interception of Carbene Alkyne Metathesis Intermediates II. Photo-Activation of Hydrazones III. Organocatalyzed Cascade Conjugate Addition/Aldol Annulation of Organoboronates
… carefully elucidated. An organocatalyzed tandem conjugate addition/Aldol annulation of organoboronates was discussed in the last chapter. A variety of nucleophiles showed good compatibility with heterocycles. In addition, the strength of boron enolate intermediates were examined by intercepting …
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Studies in Synthesis and Organocatalysis: (i) The Design and Synthesis of Novel Electron Deficient Dienes and their Application in the First Enamine Activated Organocatalytic 1,6-Conjugate Addition. (ii) The Development of a New Organocatalytic Methodology through the Combination of DNA-Based Catalysis and Organocatalysis
… The first enamine activated organocatalytic 1,6- conjugate addition was performed on the sulfonyl acceptors, using aldehydic enamines, giving excellent yields and selectivities (up to 98% yield, uniformly 99% ee). The mechanism of this reaction was explored in detail. The products of these …
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Asymmetric Syntheses With (-)-Sparteine-Complexed Benzylic and Allylic Organolithium Reagents
… was investigated. Kinetic resolution in conjugate addition reactions with alpha,beta-unsaturated lactones proceed with retention of configuration to provide 1,4-addition products with three contiguous stereogenic centers with high stereoselectivities. In all cases of a 1,4-addition …
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Conjugate Additions and Transposition of the Allylic Alcohols of Enol Ethers of 1, 2-Cyclohexanedione.
… was prepared as substrates for conjugate addition studies using organocopper reagents. The sequence involved the enol ether preparation via the enolate, alkylation with an organometalic reagent, and oxidative rearrangement with pyridinium chlorochromate followed by the conjugate …
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The Asymmetric Synthesis Of The C1'-C10' Portion of Pamamycin-621A
… portion 72 of the pamamycin-621A using a cuprate conjugate addition to join enone fragment 52 and organostannane fragment 64a. Fragments 52 and 64a were both synthesized from (S)-methylketene dimer 51.
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Chemoenzymatic Synthesis of ent-Neopinone
… a Heck reaction, aldol condensation and a 1,6-conjugate addition.
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Trifluoroethyl enol ethers, dienol ethers, and acetals: an investigation of their preparations, reactivities, and synthetic applications
… were synthesized from propargyl ketones via a conjugate addition reaction. The applications were synthetic in nature mainly involving utilization of these compounds in cycloaddition and conjugate addition reactions. The last portion of this work involved our investigation into behavior of …
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The modification of brucine derivatives as chiral ligands and its application in the asymmetric synthesis
… in the MBH reaction of alkyl vinyl ketone. In addition, asymmetric MBH reactions of alkyl vinyl ketones with aldehydes were investigated using a dual catalysis of brucine <em>N</em>-oxide and proline. In this dual catalyst system, proline was found to form iminium intermediates with …
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