Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 12 of 12 for “"congenital anomaly"”.
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Parents living within the paradoxes of infant death from life-limiting anomaly: A grounded theory study
BACKGROUND: Life-limiting congenital anomalies are the leading cause of death of infants in the United States. Most of these infants die in intensive care units with limited access to adequate palliative/end-of-life care. There is an extensive knowledge gap about the experience of the parent of …
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Genomic Approaches to Congenital Genitourinary Disorders
Congenital genitourinary disorders are the third most common congenital anomaly worldwide (1 in 135 births) and include anomalies of both the urinary and genital systems, such as prune belly syndrome (PBS), persistent cloaca, and disorders of sex development (DSD). Understanding the genetic cause …
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Analysing small-sample-sized methylation data to identify biomarkers for congenital heart defects
Congenital Heart Defects (CHDs) are the most common type of human congenital anomaly, representing 0.8~1.2% of infants at birth and accounting for over 40% of prenatal deaths. Although the exact aetiology remains a significant challenge, epigenetic modifications, such as Deoxyribonucleic Acid (DNA) …
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Design Of A Polysaccharide Derived Tissue Engineered Vascular Graft
… Doctor of Philosophy</p> <p>As the most frequent congenital anomaly and the leading cause of death, congenital heart disease is an attractive target for tissue engineering research. The challenging target to engineer a native blood vessel stems from the need to find substitutes for pediatric …
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Investigating prevalence and healthcare use of children with complex healthcare needs using data linkage. A study using multi-ethnic data from an ongoing prospective cohort: the Born in Bradford project
… and requires a multidisciplinary response. Congenital anomaly (CA) is a group of conditions requiring complex and variable input from primary and secondary healthcare. This thesis explores the literature on health system preparedness for children with complex healthcare needs and …
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Parent’s Post-traumatic Stress before and after their Infant’s Second Palliative Heart Surgery: The PatHS Descriptive Correlational Longitudinal Study
… infants born have CHD making it the most common congenital anomaly. Of those infants born with CHD, 1% have a functionally single ventricle. This type of heart defect requires three palliative heart surgeries, the first within seven days of birth, the second at 4-6 months, and the third at 2-5 …
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Machine Learning Approaches and Web-Based System to the Application of Disease Modifying Therapy for Sickle Cell
… newborn babies each year suffer either from the congenital anomaly or from an inherited disease, primarily from thalassemia and sickle cell disease. In the case of SCD, recent research has shown the beneficial effects of a drug called hydroxyurea/hydroxycarbamide in modifying the disease …
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HAPLOINSUFFICIENCY OF RAI1 AND ITS EFFECT ON BDNF EXPRESSION
Smith-Magenis Syndrome (SMS) [OMIM, #182290] is a congenital anomaly and mental retardation (MCA/MR) syndrome associated with deletion of chromosome17p11.2 [1]. The clinical phenotype has been well described and includes minor craniofacial anomalies, self-injurious behaviors as well as sleep …
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Knowing but not knowing: the experience of parents who knew about their baby’s heart defect before their baby was born
… of parents who knew about their baby's congenital heart defect (CHD) antenatally. With advances in obstetrical ultrasound and fetal echocardiography, more parents are learning of their baby's congenital anomaly before their baby is born. Little is known, however, about the experience of …
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Certain congenital anomalies : some psycho-social implications in adulthood
… implications in adulthood of being born with a congenital anomaly. The congenital anomalies - oesophageal atresia, Hirschsprung's disease and high anorectal malformations are surgically corrected at birth, but can be associated with residual problems. These problems could put patients at risk …
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Experiences of pregnancy with major fetal anomalies
… of pregnancies will receive a diagnosis of a congenital anomaly, of which a proportion are fatal. While the prevalence of congenital anomalies is low it is the leading cause of fetal death and child mortality. More women are receiving a diagnosis of a fetal anomaly during their pregnancy as a …
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Scale Development to Identify Psychosocial Distress During Pregnancy with Fetal Anomaly: A Mixed Method Study
… of distress experienced in the context of fetal anomaly. These gaps limit our ability to provide meaningful, patient-centered care during a particularly vulnerable time. My dissertation seeks to address this knowledge gap by advancing our understanding of psychosocial distress in this unique …