Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 8 of 8 for “"conformational selection"”.
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Tau Aggregation, Conformational Selection, and Inhibition
… Tau exists as a disordered monomer in dynamic conformational equilibrium. This solution-phase heterogeneity could, in part, explain conformational diversity of Tau fibrils.</p> <p>A homogeneous set of Tau fibrils transitioned to a new heterogeneous population of conformers after multiple cycles …
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Conformational Studies of Myosin and Actin with Calibrated Resonance Energy Transfer
… energy transfer was employed to study the conformational changes of actomyosin during ATP hydrolysis. To calibrate the technique, the parameters for resonance energy transfer were defined. With conformational searching algorithms to predict probe orientation, the distances measured by …
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Fret-Based Investigations of The Structure-Function Relationships In The Nmda Receptor
… noting the adherence of the domain to the conformational selection model, and the revelation of a novel conformation leading to activation hitherto unknown. Finally, we have also directly examined the conformational dynamics of the transmembrane domain of the NMDA receptor with regards to …
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The role of unfolded states in collagen degradation
… results are interpreted in light of a novel conformational selection mechanism in which collagenases only cleave locally unfolded, vulnerable states. Finally, based on the new mechanism of collagenolysis presented here, new strategies to regulate collagenolysis are proposed.
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The Role of Transmembrane Domain Helix-Helix Interactions in the Function of Pentameric Ligand-Gated Ion Channels
… lipids, which influence function primarily via a conformational selection mechanism, membrane hydrophobic thickness influences function via a kinetic mechanism - thick membranes lower the activation energy between uncoupled and coupled conformations to promote conformational transitions. In the …
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Modulation of Kras Structure and Dynamics By Kras Ubiquitination and Membrane Depolarization
… effectors and membrane. We propose a mechanism conformational selection of certain conformations and population shift towards those conformations can help overcome the deleterious effects from monoubiquitination.</p> <p>Proliferating cells have a depolarized membrane, which was recently shown to …
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Organised Chaos: defining different degrees of intrinsic disorder by molecular dynamics methods
… which results in an enrichment of the disordered conformational ensemble with secondary structure motifs that may act as molecular recognition features (MoRFs), or nucleation sites. According to this hypothesis, specific MoRFs are recognized by receptors and fold upon binding, within a scheme that …
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Markov state modeling of binding and conformational changes of proteins
… other molecules. However, the interplay between conformational change and binding is not fully understood. In this work, this interplay is investigated with molecular dynamics (MD) simulations of the protein-peptide system Mdm2-PMI and by analysis of data from relaxation experiments. The central …