Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 19 of 19 for “"conformational properties"”.
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Fluorination Effect on the Conformational Properties of Alkanes
… temperature-dependent studies and quantified the conformational difference.
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The Impact of Nucleoside Sugar Modification on Biochemical DNA Transactions
… studies, we reveal how sugar structure and conformational properties impact polymerase incorporation and extension behavior. The analogues proposed for this study allow an examination of structural and conformational properties, but also, this group of analogues comprises an important class …
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Relationships Between Physical, Chemical, and Functional Properties of Enzymatically-Modified and Unmodified Soy Protein (Nmr, Plasteins, Denaturation, Extrusion)
… physical, chemical, functional, and gross conformational properties of enzymatically-modified and unmodified soy protein isolate (SPI). Systems were analyzed for average molecular weight (AMW), TCA and water solubility, functionality, process performance, (twin-screw extrusion), and …
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Enzyme catalysed modification of polymers
… of epoxide could not be obtained because of the conformational properties of the partially epoxidised polymer. Application of this process to the Baeyer-Villiger reaction of poly(vinyl phenyl ketone) and poly(vinyl methyl ketone) were unsuccessful. The lack of reactivity was found to be a …
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Polymers containing calix[4]arenes and triptycenes : new syntheses, properties and applications
… constructing the functional polymers. Unusual properties, with the emphasis on mechanical and sensory properties, are demonstrated. In Chapter 2, early investigations on the synthesis of main-chain calix[4]arene polymers are introduced. High molecular-weight main-chain calixarene homopolymers …
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Development of Free Energy Calculation Methods for the Study of Monosaccharides Conformation in Computer Simulations
… and apply new computational tools to investigate conformational properties and to improve the description of carbohydrates in the framework of molecular dynamics simulations. In the field of monosaccharides, modeling the system within the molecular dynamics framework presents troublesome aspects. …
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Stereoselective synthesis of perhydrobenzo[4.5.6]cholestanes
… derivatives. The structural and conformational properties of the condensation products were studied with the aid of ¹H NMR, ¹³C NMR, and IR spectroscopy.
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Conformational behaviour of selected silicon- and germanium-containing ring systems
… germacyclohexane was synthesized and the conformational behaviour of the compound, in terms of axial and equatorial chair conformers, was investigated by means of dynamic nuclear magnetic resonance (DNMR) measurements. The result from the NMR experiment showed the axial/equatorial ratio to …
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INVESTIGATION OF BIOMOLECULAR INTERACTIONS FOR DEVELOPMENT OF SENSORS AND DIAGNOSTICS
… of the dynamics, specificity and the conformational properties of these functional nucleic acids in a manner inaccessible via traditional interaction studies. These interactions were then adapted to aptamer-based detecting methods that at the ensemble or bulk scale, specifically taking …
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The rheology and dynamic properties of biopolymers in a colloidal suspension
… nature as well as favourable rheological properties, many industries have now opted to use biopolymers in their products and operations. Biopolymers, such as xanthan gum, provide good suspension and stability to solutions and exhibit excellent resistance against high shear and high …
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Development of Surface Plasmon Resonance and Top-Down Mass Spectrometry Approaches to Monitor the Conformational Properties of Amyloidogenic Peptides and Their Enzymatic Cleavage: a Specific Application to Uncover the Mechanisms of Digestion of Branched Ubiquitin-Tau Proteoforms by the Human 20S Proteasome [Sviluppo di approcci di risonanza plasmonica di superficie e spettrometria di massa top-down per monitorare le proprietà conformazionali dei peptidi amiloidogenici e la loro digestione enzimatica: un'applicazione specifica per scoprire i meccanismi di digestione delle proteoforme ramificate di ubiquitina-tau da parte del proteasoma umano 20S]
L'insorgenza e la progressione della neurodegenerazione coinvolgono una rete diversificata di processi e componenti, come il ripiegamento, la selezione, il traffico e il turnover delle proteine, il sistema immunitario, la neuroinfiammazione e i tratti genetici. Un comune segno distintivo istologico …
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Triplex formation as monitored by EPR spectroscopy and molecular dynamics studies of spin -probe -labeled DNAs
… to provide insight into structural and dynamics properties of DNAs, proteins, and related systems. Spin labels have been extensively used to study the dynamics of oligonucleotides. An example of this is 5-membered ring nitroxide 5-(2,2,5,5-tetramethyl-3-ethynylpyrrolidine-1-oxyl)-uridine, which …
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Computational Investigation On The Structural Properties Of Neurofilaments And Their Sidearms
… diameter and consequently the nerve conduction properties. On the other hand, abnormal NF accumulation has been the hallmark of debilitating neurodegenerative disorders. NF compaction is also one of the pathological manifestations of traumatic axonal Injury. However, the exact relation between …
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Chemistry and properties of perhydrobenzo[4.5.6]cholestanes
… interpretations about their structural ~d conformational properties and related thermodynamic stabilities. 2 The Diels-Alder cycloaddition of 6-methylenecholest-4-en-3p-ol 96 with acrolein and methyl vinyl ketone gave 6' a-acetyl-4P,4' ,5' p,6' -tetrahydrobenzo[ 4.5 .6]cholestan-3 Pyl …
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SYNTHESIS, BIOLOGICAL ACTIVITY AND CONFORMATIONAL ANALYSIS OF FRAGMENT ANALOGUES OF ALPHA-MELANOTROPIN (PEPTIDE, STRUCTURE-FUNCTION, PHENYLGLYCINE, NMR, TETRAHYDROISOQUINOLINE-3-CARBOXYLATE).
… enhanced potency. In this regard, a series of conformationally restricted linear and cyclic fragment analogues of α-MSH have been prepared and carefully analyzed by both biological and biophysical methods. Conformational restriction was incorporated in α-MSH fragment analogues, by: (1) …
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Assembly and biochemical properties of a human chaperone/co-chaperone protein complex
… of this zone alters binding, function and conformational properties of the Hsc70 and HSJ1b interaction. X-ray crystallography studies on the full length and the domain complexes were carried out, leading to the structure of the apo form of the nucleotide binding domain of Hsc70. Preliminary …
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Targeting Alternative Conformational States of the HIV-1 Rev Response Element Stem IIB using Small Molecules
… on RRE to form ribonucleoprotein complex. Conformational flexibility at this stem IIB region has been shown to be important for Rev binding. In addition, m6A modifications on HIV-1 RNA has shown their critical roles to HIV-1 replication, and two probably essential m6A sites on purine-rich …
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Synthetic strategies for the design of platinum anticancer drug candidates
… and dansyl-dpm). The photophysical and solution conformational properties of the complexes [Pt(dpm')C12], where dpm' is one of the three ligands described above, are presented. The thermal and photolytic decomposition products and the hydrogen peroxide oxidation products were investigated. …
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Brownian dynamics simulation of soft matter with hydrodynamics: methods for constrained systems and shear processing of 2D materials
… and unique electrical, optical, and catalytic properties while being lightweight, strong, and flexible. This has led to graphene seeing use in separations, biomedical applications, flexible electronics, and more. Meanwhile, synthetic 2D polymers, a relatively new field of study, represent a …