Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 12 of 12 for “"conformational entropy"”.
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Conformational Entropy in PEPCK Catalysis: Dynamic Motions Critical to Function
Enzymes increase the rate at which chemical reactions occur. How they achieve this rate increase has been an area of intense research for many years. Multiple studies have shown that dynamic motions of individual protein segments can play a role in enzyme function. Our enzyme of interest, …
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Biophysical mechanisms of intrinsic protein disorder: lessons from a protein backbone model
… the thermodynamics, particularly free energy and entropy, that drive the collapse and aggregation of short IDRs as well as the mechanisms underlying structural transitions. To investigate these phenomena, we use a protein backbone model (i.e. oligoglycine) that has been experimentally and …
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Structure, Function & Dynamics At The Membrane
… about the role of methyl dynamics in protein conformational entropy, this view has been attained solely with soluble protein systems; the dynamic behavior of membrane proteins remains to be elucidated. Utilizing a newly designed labeling technique for producing deuterated, appropriately …
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Investigations of the Non-Covalent CH-Π Interactions Using Molecular Torsional Balances
… interactions were studied, such as sterics, conformational entropy, cooperativity, deuterium isotope effect, substitution effects, and solvent effects. It showed that due to the weak nature of CH-pi interactions, many forces can contribute on determining their interacting energies with …
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Physics-based predictions of RNA loop stability and structures
… structure prediction is the evaluation of the entropy for RNA tertiary folds. In particular, the entropies of structures with multiple loops and helices can be highly convoluted due to the volume exclusion between the loops and helices. In the first project, we develop a new conformational …
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Exploration of a liquid droplet state for α-synuclein in vitro and in vivo
… the droplet state is stabilised by the large conformational entropy associated with non-specific side-chain interactions. Our results indicate that the droplet state could be, at least transiently, accessible to most proteins under conditions found in the cellular environment.
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Equilibrium Melting Temperature Determination of Semicrystalline Polymers through Nonlinear Hoffman-Weeks Extrapolation and Secondary Crystallization of Ethylene/Styrene Copolymers
… tentatively explained by a decrease in the molar conformational entropy of the remaining amorphous fraction as a result of secondary crystallization, although the possible role of an increase of crystal lateral dimensions with time cannot be rigorously ruled out.
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Proteins on the edge : transitions of structure ensembles in protein unfolding and protein-protein binding
… not generally restrict protein flexibility and conformational entropy may be lost but also gained in the process. Current models of recognition do not account for overall protein flexibility or make assumptions that are incompatible with kinetic observations. I combined the simulation data with …
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Kinetics of Disordered Proteins and their Interactions
… of this state become slower. Additionally, the conformational entropy of the protein backbone is increased, with the small molecule forming nanosecond-lifetime π-stacking interactions with aromatic side chains. These findings are consistent with nuclear magnetic resonance experiments, and …
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Self-assembly behavior in hydrophilic block copolymers
… is believed to arise from the same loss of conformational entropy that is responsible for “the hydrophobic effect” but driven by a competition for water of the two blocks. In that sense this phenomenon should be described as the “hydrophilic effect”.
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Crystallization and Melting Behavior of Linear Polyethylene and Ethylene/Styrene Copolymers and Chain Length Dependence of Spherulitic Growth Rate for Poly(Ethylene Oxide) Fractions
… with time is attributed to a decrease in the conformational entropy of the amorphous fraction as a result of constraints imposed by primary and secondary crystals. To further understand the mechanism of formation of low melting crystals, quasi-isothermal crystallization experiments were …
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Pattern Formation and Phase Behavior in PS-B-SI Containing Block Copolymer Thin Film
… is thermodynamically controlled by the conformational entropies of two blocks and the interfacial energy. On the contrary, giant shape amphiphiles are consisted of particles and polymer chains. There is no conformational entropy for particles, and the interfacial energy is different from …