Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 9 of 9 for “"conformational control"”.
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Stereochemistry of small molecules: Configurational and conformational control
… conditions. Another major project focused on conformational control of acyclic molecules. Using X-ray crystallography and NMR spectroscopy, we found that the 2,6-disubstituted aryl group eclipses its geminal hydrogen, and induces an antiperiplanar relationship of the geminal and vicinal …
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Toward charge separation through conformational control in copper coordination complexes
Submission published under a 24 month embargo labeled 'U of I Access', the embargo will last until 2025-08-01
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Single molecule force spectroscopy of single stranded DNA binding protein and Rep helicase
… we present for the first time study on the conformational control of Rep helicase using an optical trap. We found that crosslinking-mediated conformational arrest of a dynamic subdomain in so-called “closed” orientation converted the Superfamily I (SFI) helicase, Rep, from a very poor DNA …
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Modulation of The Receptor Gating Mechanism and Allosteric Communication In Ionotropic Glutamate Receptors
… mechanism and inadequate knowledge regarding the conformational dynamics of the receptors during channel gating mechanism have been some of the limiting factors in elucidating the structure-function relation of iGluRs. Thus, to understand the conformational dynamics of iGluR family and correlate …
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A New Approach to Drug Delivery: Non- Peptidic, High Load Macrocyclic Alternatives to Cell Penetrating Peptides
… the synthesis of these molecules and how conformational control and selective functionalisation can give an array of molecules with customised properties; this allows for various applications including those of biological relevance. The copper catalysed alkyne-azide cycloaddition (CuAAC) …
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Conjugated polymers and designed interfaces : conformational analysis and applications
… and fluorescence. In this dissertation, the conformational changes and their effects on photophysics in different environments will be discussed. In Chapter 1, the basic principles to understand this thesis will be reviewed, including the processes of absorption and emission, exciton …
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Exploration of helicase mechanisms at single molecule level: answering decades old questions and bioengineering super proteins
… led to determination of the key residues that control shuttling speed, ATPase activity, and directionality. Second, we tested the effects of the DNA lesions on Rep translocation, observing that the irregularities encompassing 1‐3 nucleotides in the backbone and nucleobases only caused transient …
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Exploration of helicase mechanisms at single molecule level: answering decades old questions and bioengineering super proteins
… led to determination of the key residues that control shuttling speed, ATPase activity, and directionality. Second, we tested the effects of the DNA lesions on Rep translocation, observing that the irregularities encompassing 1‐3 nucleotides in the backbone and nucleobases only caused transient …
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Design, synthesis, and structural elucidation of spiroligomers for targeted molecular recognition
… pure bis-amino acid building blocks. By controlling backbone stereochemistry, spiroligomers enable precise and predictable three-dimensional presentation of side chains, offering a level of conformational control that extends beyond conventional peptides. This dissertation integrates …