Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 5 of 5 for “"conformation state"”.
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Synthesis and Physical Properties of Helical Nanosized Quinoline-based Foldamers: Structure, dynamics and photoinduced electron transport
… mass spectrometry afforded access to the conformation state of foldamers in gas phase; DOSY and fluorescence anisotropy assessed the diffusion (translational and rotational, respectively) of foldamers in solution. All of these techniques revealed that quinoline-based foldamers are rigid …
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Development of Bioluminescent Biosensors Monitoring Activity of the Merlin Tumour Suppressor
… biosensor aimed at studying Merlin’s changes in conformation state. In addition, we design a bimolecular split-luciferase system to investigate Merlin’s regulation of the Hippo pathway, a key downstream effector with well-established roles in cancer biology. Ultimately, these biosensors enable …
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Amyloid-beta signaling in physiology and pathology: from astrocytes to SUMO
… which are dependent on the concentration and conformation state. Ultimately, knowledge of both normal Abeta physiology as well as Abeta pathology are necessary to truly understand Alzheimer's disease and enable development of effective therapeutics.
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Mechanistic and Engineering Studies of LOV Photoreceptors in Yeast
… characterization of LOV proteins in the dark state, the challenge has been to fully characterize the structural properties and mechanisms of action in the functional lit states. Owing to the highly dynamic conformation-state changes driven by blue-light activation, the structure-function …
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Design and testing of fiber-constrained electroactive polymer
Soft robotics take advantage of active materials to regenerate many complex motions, including low-force functions, such as camouflage, micro-grabbing, or agile locomotion of micro robot. For these applications, traditional actuators, like electric motors and combustion engines, are unnecessarily …