Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 5 of 5 for “"confocal microscopy imaging"”.
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Characterization and modeling of cell activation upon TGF-β1 stimulation in a 3-D culture system
… with immunofluorescence staining (IF) and confocal microscopy imaging of α-SMA in each cell embedded layer. Our results revealed the spatial-temporal profiles of the conversion from normal fibroblasts to myofibroblasts in 3-D culture upon TGF-β1stimulation. The conversion starting time, …
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Investigating the movement of intestinal intraepithelial lymphocytes using an organoid co-culture system
… for long-term and by performing bright field and confocal microscopy imaging of the co-culture, I was able to visualize IEL movements. Indeed, IELs were observed to be highly motile inside organoids similar to previous studies. IL-15, a chemokine which is known to promote IEL proliferation and …
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Investigating the aggregation of TDP-43 in models of Amyotrophic Lateral Sclerosis
… pathology in established cell models using microscopy techniques to investigate the relationship of pathological aggregate species and cellular dysfunction. We have characterized stable cell models expressing EGFP-TDP-43 to identify key pathological hallmarks of disease at the molecular …
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Investigation of enteric neuron and type 2 lymphocyte interactions at homeostasis and during Nippostrongylus brasiliensis infection
… how NMU-ergic neurons regulate type 2 immunity. Confocal microscopy imaging of tissues from an *Nmu<sup>Cre-iRFP670</sup>* fate mapper revealed that ILC2s closely associate with enteric NMU-ergic in either steady-state conditions or after infection with *N. brasiliensis*. Conditional deletion of …
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Investigating the integrity of the vasculature and structural relationships of pericytes, astrocytes and the endothelial glycocalyx in an ex vivo hyperglycaemic rat retinal model
… lectin. Fluorescent signals were detected using confocal microscopy imaging where Z-stack images were randomly sampled from the mid-peripheral retina. Images were analysed using Image J software. Additionally, western blotting was used to determine the abundance of syndecan-1 and heat shock …