Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 7 of 7 for “"conditional alleles"”.
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Generation of genetically modified mice with conditional alleles of Dyrk1a : a minimal animal model of Down syndrome
Down Syndrom (Trisomie 21) ist die Hauptursache für geistige Behinderung. Die “Down Syndrom kritische Region“ auf dem menschlichen Chromosom 21 ist ausschlaggebend für die Trisomie 21-assoziierte geistige Behinderung und für die Monosomie 21-assoziierte Mikrocephalie. Unter den bisher ungefähr zwei …
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Artificial Intron Technology to Generate Conditional Knock-Out Mice
… pathology. Current methods used to produce conditional knockouts have limitations on conditional allele placement and modification varies among genes in different organisms. Thus, a system for generating conditional alleles with fidelity remains a challenge. My goal was to examine an …
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IDENTIFICATION OF SPLICING PATHWAY MUTATIONS VIA TARGETED SEQUENCING
… lineage. Through these screens I have isolated conditional alleles of spliceosome components and investigated the mechanism by which some of these mutations disrupt splicing. Furthermore, I have identified genes in other nuclear processes, such as transcription and chromatin remodeling, which …
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Technology development in mouse genetics and epigenetics
… modifications, GFP and mCherry reporter alleles, epitope-tagged alleles, and conditional alleles. Another interesting area of research in mouse genetics is epigenetic regulation, specifically how DNA methylation regulates development, gene expression, and cell state. Multiple studies have …
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EXC-5 Controls Intracellular Trafficking in Order to Maintain the Apical Structure of the C. elegans Excretory Canal
… EMS non-complementation screen to identify new alleles of EXC-5, an EMS screen to identify genetic enhancers of EXC-5, methods to create an excretory canal-specific RNAi strain of C. elegans, the genetic interactions between exc-5, cdc-42, mig-2, ced-10 and other genes, the organization of …
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Molecular and Functional Characterization of Pyramidal Cell Types in the Frontal Cortex of Mouse Brain
… characterization using silencing viruses and conditional alleles. We also showed direct utility of TRAP data in elucidating cortex specific contribution to the complex neurological disorder, Wolfram Syndrome. Therefore, a combination of specific gene driver selection, BAC transgenesis methods …
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Integration of ATM, ATR, and DNA-PKcs Signaling Maintains Genome Integrity During Neurogenesis
… germ line Prkdc inactivated in combination with conditional alleles for Atm and Atr to assess if these kinases function cooperatively in the DDR during neural development, consequently defining the role(s) of DNA-PKcs during neurogenesis.</p> <p>We found DNA-PKcs loss sensitized DNA damage …